Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0246 | 0.1672 | 0.3388 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.1632 | 0.3307 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0458 | 0.4934 | 1 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Echinococcus multilocularis | 0.0142 | 0.0066 | 0.0133 | |
Brugia malayi | Protein kinase domain containing protein | 0.0146 | 0.0136 | 0.0277 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0146 | 0.0136 | 0.0277 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0146 | 0.0136 | 0.0277 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0146 | 0.0136 | 0.0277 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0246 | 0.1672 | 0.3388 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0458 | 0.4934 | 1 |
Echinococcus granulosus | insulin receptor | 0.0146 | 0.0136 | 0.0277 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0246 | 0.1672 | 0.3388 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0146 | 0.0136 | 0.0277 |
Schistosoma mansoni | tyrosine kinase | 0.0246 | 0.1672 | 0.3388 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.0788 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0458 | 0.4934 | 1 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0138 | 0 | 0.5 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.1632 | 0.3307 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0138 | 0 | 0.5 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0458 | 0.4934 | 1 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.0136 | 0.0277 |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.1632 | 0.3307 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0246 | 0.1672 | 0.3388 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.0788 | 1 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0458 | 0.4934 | 1 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0146 | 0.0136 | 0.0277 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 240 nM | Inhibition murine leukemia L1210 cell growth in culture | ChEMBL. | 3560161 |
IC50 (functional) | = 1800 nM | Inhibition of human colon tumor (HCT-8) cell growth in culture | ChEMBL. | 3560161 |
ILS (functional) | = 22 % | Percentage increase in life span of tumor bearing animals compared to non treated, tumor-bearing controls when treated at the optimal dose of 13.3 mg/kg/day ip (P388) | ChEMBL. | 3560161 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 3560161 | |
Mus musculus | ChEMBL23 | 3560161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.