Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.5152 | 0.5152 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0149 | 0.5152 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.006 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cysteine protease | 0.0077 | 0.0976 | 0.1895 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.01 | 0.2305 | 0.4474 |
Plasmodium vivax | unspecified product | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0077 | 0.0976 | 0.1895 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.006 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Brugia malayi | cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0077 | 0.0976 | 0.1895 |
Echinococcus granulosus | cathepsin L | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.5152 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0077 | 0.0976 | 0.1895 |
Leishmania major | cysteine peptidase A (CPA) | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.2305 | 0.4474 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.5152 | 0.5152 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.0976 | 0.1895 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0077 | 0.0976 | 0.1895 |
Plasmodium falciparum | glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0.2305 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.006 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0105 | 0.261 | 0.107 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Trypanosoma brucei | trypanothione reductase | 0.0105 | 0.261 | 0.5066 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.2305 | 0.4474 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0077 | 0.0976 | 0.1895 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0077 | 0.0976 | 0.1895 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.006 | 0 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0149 | 0.5152 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.006 | 0 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Treponema pallidum | NADH oxidase | 0.006 | 0 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0149 | 0.5152 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0077 | 0.0976 | 0.0976 |
Brugia malayi | Thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0077 | 0.0976 | 0.1895 |
Toxoplasma gondii | thioredoxin reductase | 0.0105 | 0.261 | 0.5066 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0149 | 0.5152 | 1 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | vivapain-1 | 0.0077 | 0.0976 | 0.1895 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Brugia malayi | glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Loa Loa (eye worm) | glutathione reductase | 0.0105 | 0.261 | 0.107 |
Leishmania major | cathepsin L-like protease | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | vivapain-2 | 0.0149 | 0.5152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | vivapain-2 | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0077 | 0.0976 | 0.1895 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.006 | 0 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0149 | 0.5152 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0149 | 0.5152 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.006 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0105 | 0.261 | 0.5066 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.01 | 0.2305 | 0.2305 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0149 | 0.5152 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.01 | 0.2305 | 0.4474 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0149 | 0.5152 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0105 | 0.261 | 1 |
Leishmania major | trypanothione reductase | 0.0105 | 0.261 | 0.5066 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0105 | 0.261 | 0.5066 |
Onchocerca volvulus | 0.0149 | 0.5152 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.2305 | 0.4474 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Plasmodium vivax | vivapain-3 | 0.0077 | 0.0976 | 0.1895 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0105 | 0.261 | 0.5066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0077 | 0.0976 | 0.1895 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0077 | 0.0976 | 0.1895 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.01 | 0.2305 | 0.4474 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0149 | 0.5152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0149 | 0.5152 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0149 | 0.5152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0149 | 0.5152 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0105 | 0.261 | 0.5066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cleavage (functional) | = 1 ug ml-1 | In vitro concentration inhibiting DNA gyrase induced cleavage in E. coli H560. | ChEMBL. | 1366133 |
MIC (functional) | = 1.6 ug ml-1 | In vitro antibacterial activity against gram negative E. coli Vogel. | ChEMBL. | 1366133 |
PD50 (functional) | = 0.5 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by E. coli vogel on subcutaneous injection. | ChEMBL. | 1366133 |
PD50 (functional) | = 2 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by E. coli Vogel on oral administration by gavage. | ChEMBL. | 1366133 |
PD50 (functional) | = 32 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by S. pyogenes C-203 on subcutaneous injection | ChEMBL. | 1366133 |
PD50 (functional) | = 49 mg kg-1 | In vivo potency against acute systemic infection in mouse caused by S. pyogenes C-203 on oral administration by gavage | ChEMBL. | 1366133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.