Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.4264 | 0.6495 |
Toxoplasma gondii | aminopeptidase N protein | 0.0354 | 1 | 0.5 |
Onchocerca volvulus | 0.0272 | 0.67 | 1 | |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0268 | 0.6565 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0354 | 1 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0105 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0105 | 0 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0272 | 0.67 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0268 | 0.6565 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0105 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0272 | 0.67 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0105 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0105 | 0 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0268 | 0.6565 | 0.9799 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0354 | 1 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0105 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0105 | 0 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0268 | 0.6565 | 0.9799 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0354 | 1 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0105 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0272 | 0.67 | 1 |
Brugia malayi | hypothetical protein | 0.0208 | 0.4129 | 0.6163 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0227 | 0.4887 | 0.7445 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.2452 | 0.3734 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.2 ug ml-1 | Evaluated for minimum inhibitory concentration against gram-negative bacteria Escherichia coli Vogel | ChEMBL. | 2374153 |
MIC (functional) | = 2.5 ug ml-1 | Evaluated for minimum concentration needed to produce linear DNA at an intensity relative to oxolinic acid at 10 mg/mL. by gyrase mediated cleavage of DNA in Escherichia coli 560. | ChEMBL. | 2374153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.