Detailed information for compound 941212

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.038 | Formula: C26H37ClN2O
  • H donors: 1 H acceptors: 1 LogP: 6.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NCC(c1ccccc1)(c1ccccc1)CCCN1C(C)CCCC1C.Cl
  • InChi: 1S/C26H36N2O.ClH/c1-21-12-10-13-22(2)28(21)19-11-18-26(20-27-23(3)29,24-14-6-4-7-15-24)25-16-8-5-9-17-25;/h4-9,14-17,21-22H,10-13,18-20H2,1-3H3,(H,27,29);1H
  • InChiKey: SLUKXANWSPGQCY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.1061 0.1455
Entamoeba histolytica hypothetical protein 0.0071 0.0315 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0159 0.5254
Loa Loa (eye worm) glutathione reductase 0.0093 0.0432 0.24
Schistosoma mansoni hypothetical protein 0.0071 0.0315 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0271 0.0782
Trichomonas vaginalis pc-MYB2, putative 0.0046 0.0184 0.6069
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0159 0.0421
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0066
Brugia malayi Smad1 0.0024 0.0067 0.0374
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0023 0.0126
Brugia malayi MH1 domain containing protein 0.0013 0.0011 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0023 0.0523
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0432 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0144 0.4746
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0271 0.0782
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1365 0.7164 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0111 0.04
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0141 0.0406
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0067 0.0195
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Brugia malayi hypothetical protein 0.0071 0.0315 0.1751
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0023 0.0065
Leishmania major DNA polymerase eta, putative 0.0063 0.0273 0.6286
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0141 0.0138
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0111 0.2568
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0111 0.2521
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0141 0.4641
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0536 0.2777 0.281
Plasmodium falciparum glutathione reductase 0.0093 0.0432 1
Leishmania major DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0273 0.6286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0111 0.2521
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0184 0.6069
Trichomonas vaginalis pc-MYB2, putative 0.0046 0.0184 0.6069
Brugia malayi hypothetical protein 0.0296 0.1507 0.8374
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0271 0.0782
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0141 0.0165
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.1061 0.1455
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0127
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0039 0.0113
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.1061 0.1455
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0159 0.5254
Leishmania major DNA polymerase eta, putative 0.0037 0.0135 0.3074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0273 0.1514
Giardia lamblia DINP protein human, muc B family 0.0038 0.0141 0.7565
Plasmodium falciparum thioredoxin reductase 0.0093 0.0432 1
Entamoeba histolytica hypothetical protein 0.0071 0.0315 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.02 0.1113
Echinococcus granulosus bloom syndrome protein 0.0024 0.0066 0.0189
Schistosoma mansoni smad 0.0024 0.0067 0.0195
Brugia malayi Thioredoxin reductase 0.0093 0.0432 0.24
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0067 0.0195
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0135 0.3074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0111 0.2521
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0079 0.1767
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0067 0.0195
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0202 0.4686
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0184 0.5834
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0184 0.5834
Echinococcus granulosus dna polymerase kappa 0.0038 0.0141 0.0406
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0271 0.0782
Schistosoma mansoni smad1 5 8 and 0.0024 0.0067 0.0195
Echinococcus granulosus Smad4 0.0024 0.0067 0.0195
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0023 0.0462
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0315 0.0911
Plasmodium falciparum glutathione reductase 0.0032 0.0111 0.2568
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1365 0.7164 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Schistosoma mansoni hypothetical protein 0.0034 0.0118 0.0342
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0184 0.6069
Leishmania major hypothetical protein, conserved 0.0049 0.0202 0.4652
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0432 0.1248
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0058 0.0168
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0023 0.0462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0111 0.0616
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0023 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0141 0.3212
Schistosoma mansoni smad1 5 8 and 0.0024 0.0067 0.0195
Giardia lamblia Myb 1-like protein 0.0046 0.0185 1
Trichomonas vaginalis MYB72, putative 0.0046 0.0184 0.6069
Brugia malayi isocitrate dehydrogenase 0.0015 0.0023 0.0126
Brugia malayi chromobox protein homolog 3 0.0038 0.0144 0.0799
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0141 0.0406
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0303 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0066 0.2163
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0066 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0079 0.1767
Echinococcus multilocularis GPCR, family 2 0.0016 0.0023 0.0066
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0536 0.2777 0.2695
Loa Loa (eye worm) hypothetical protein 0.0296 0.1507 0.8374
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0111 0.2521
Echinococcus granulosus dna polymerase eta 0.0063 0.0273 0.0788
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0111 0.2568
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0185 0.6107
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0144 0.4746
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0111 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0536 0.2777 0.2775
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0111 0.2521
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.1061 0.1455
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0111 0.2521
Trypanosoma brucei unspecified product 0.0026 0.0079 0.1767
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0555
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0141 0.4461
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0141 0.0406
Loa Loa (eye worm) Smad1 0.0024 0.0067 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0085 0.2789
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.1125
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0184 0.5834
Loa Loa (eye worm) hypothetical protein 0.0049 0.02 0.1113
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1901 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0111 0.0321
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.1187 0.163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0065
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0141 0.3212
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0184 0.6069
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1901 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0202 0.4652
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.02 0.1113
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0111 0.0108
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0003 0.0008
Echinococcus multilocularis chromobox protein 1 0.0068 0.0303 0.0876
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0185 0.6107
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0202 0.4686
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0066
Echinococcus granulosus geminin 0.0665 0.3461 1
Loa Loa (eye worm) transcription factor SMAD2 0.0351 0.18 1
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0141 0.0406
Brugia malayi Heterochromatin protein 1 0.0068 0.0303 0.1683
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0065
Brugia malayi hypothetical protein 0.0032 0.011 0.0609
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0184 0.6069
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0303 1
Brugia malayi hypothetical protein 0.0049 0.0202 0.1125
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0111 0.3661
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0141 0.3212
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0067 0.0374
Echinococcus granulosus tar DNA binding protein 0.0062 0.0271 0.0782
Trypanosoma brucei unspecified product 0.0038 0.0141 0.3212
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0024 0.0087
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0273 0.1514
Mycobacterium tuberculosis Probable reductase 0.0212 0.1061 0.1455
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0202 0.4652
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0023 0.0081
Brugia malayi MH2 domain containing protein 0.0351 0.18 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0315 0.0911
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0023 0.0127
Trichomonas vaginalis C-MYB, putative 0.0046 0.0184 0.6069
Echinococcus granulosus GPCR family 2 0.0016 0.0023 0.0066
Brugia malayi MH2 domain containing protein 0.0024 0.0067 0.0374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Echinococcus multilocularis dna polymerase eta 0.0063 0.0273 0.0788
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.1187 0.163
Plasmodium falciparum thioredoxin reductase 0.0032 0.0111 0.2568
Leishmania major trypanothione reductase 0.0093 0.0432 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0271 0.1504
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0271 0.1504
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0141 0.0781
Schistosoma mansoni hypothetical protein 0.0665 0.3461 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0111 0.0108
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0066 0.2163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0432 0.0573
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0003 0.001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0023 0.0462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0184 0.5834
Brugia malayi MH1 domain containing protein 0.0024 0.0067 0.0374
Echinococcus granulosus chromobox protein 1 0.0068 0.0303 0.0876
Brugia malayi glutathione reductase 0.0093 0.0432 0.24
Loa Loa (eye worm) MH2 domain-containing protein 0.0351 0.18 1
Echinococcus multilocularis Smad4 0.0024 0.0067 0.0195
Schistosoma mansoni hypothetical protein 0.0022 0.0058 0.0168
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0003 0.0064
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0023 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0111 0.0108
Entamoeba histolytica hypothetical protein 0.0071 0.0315 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0118 0.0657
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0271 0.0782
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0023 0.0081
Trichomonas vaginalis MYB, putative 0.0046 0.0185 0.6107
Schistosoma mansoni chromobox protein 0.0068 0.0303 0.0876
Trypanosoma brucei unspecified product 0.0026 0.0079 0.1767
Loa Loa (eye worm) hypothetical protein 0.0119 0.0569 0.3162
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0066 0.0189
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.02 0.1113
Schistosoma mansoni hypothetical protein 0.0665 0.3461 1
Brugia malayi MH2 domain containing protein 0.0024 0.0067 0.0374
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0023 0.0065
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.005 0.1166
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0141 0.4641
Echinococcus multilocularis geminin 0.0665 0.3461 1
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0085 0.2789
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0141 0.3212
Trichomonas vaginalis C-MYB, putative 0.0046 0.0184 0.6069
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0432 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0111 0.2521
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0432 0.24
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0108
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0141 0.0165
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0202 0.4686
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0315 0.0911
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0536 0.2777 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0184 0.6069
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0046 0.0185 0.0666
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0066 0.0365
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0015
Schistosoma mansoni smad1 5 8 and 0.0024 0.0067 0.0195
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0025 0.0581
Loa Loa (eye worm) RecQ helicase 0.0024 0.0066 0.0364
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0244
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0111 0.5936
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0067 0.0195
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0003 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0271 0.0782
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0135 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Echinococcus granulosus chromobox protein 1 0.0068 0.0303 0.0876
Plasmodium vivax glutathione reductase, putative 0.0093 0.0432 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0023 0.0127
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0271 0.1504
Brugia malayi RNA binding protein 0.0062 0.0271 0.1504
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0141 0.0406
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0111 0.2521
Onchocerca volvulus 0.0296 0.1507 1
Brugia malayi TAR-binding protein 0.0062 0.0271 0.1504
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0111 0.0321
Loa Loa (eye worm) nuclear factor I 0.0013 0.0011 0.006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0023 0.0462
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0058 0.0168
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.006
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0273 0.6286
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0202 0.4652
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0432 0.1248
Entamoeba histolytica hypothetical protein 0.0071 0.0315 1
Schistosoma mansoni DNA polymerase eta 0.0063 0.0273 0.0788
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0111 0.2521
Toxoplasma gondii thioredoxin reductase 0.0093 0.0432 0.1556
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0141 0.0781
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0046 0.0184 0.5834
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0111 0.2568
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.1061 0.1455
Brugia malayi MH1 domain containing protein 0.0013 0.0011 0.006
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0067 0.0374
Echinococcus multilocularis chromobox protein 1 0.0068 0.0303 0.0876
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0079 0.1767
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0657
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.1187 0.0205
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0046 0.0184 0.6069
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0111 0.3661
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0141 0.0138
Schistosoma mansoni Smad4 0.0024 0.0067 0.0195
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0111 0.0321
Schistosoma mansoni chromobox protein 0.0068 0.0303 0.0876
Brugia malayi MH1 domain containing protein 0.0024 0.0067 0.0374
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0023 0.0065
Loa Loa (eye worm) RNA binding protein 0.0062 0.0271 0.1504
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0067 0.0195
Brugia malayi polk-prov protein 0.0012 0.0003 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0303 0.1683
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0066
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0003 0.001
Echinococcus multilocularis smad 0.0024 0.0067 0.0195
Trichomonas vaginalis MYB3r3, putative 0.0046 0.0184 0.6069
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1901 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0023 0.0523
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0111 0.0124
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0144 0.0312
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0111 0.2568
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0007 0.0235
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0066 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0141 0.3212
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.1187 0.163
Trypanosoma brucei trypanothione reductase 0.0093 0.0432 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0023 0.0462
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0023 0.0126
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0111 0.2521
Echinococcus granulosus smad 0.0024 0.0067 0.0195
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0202 0.0729
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0799

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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