Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0114 | 0.6902 | 0.7832 |
Echinococcus multilocularis | peroxidasin | 0.0076 | 0.3144 | 0.3567 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.3144 | 0.3144 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.3144 | 0.3144 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.183 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0055 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.183 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0076 | 0.3144 | 0.3144 |
Brugia malayi | CHE-14 protein | 0.0055 | 0.1074 | 0.1074 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0063 | 0.183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0055 | 0.1074 | 0.1219 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.3144 | 0.3144 |
Schistosoma mansoni | peroxidasin | 0.0076 | 0.3144 | 0.3567 |
Schistosoma mansoni | patched 1 | 0.0055 | 0.1074 | 0.1219 |
Brugia malayi | Blistered cuticle protein 3 | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.6902 | 0.7832 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 0.6902 | 0.7832 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0134 | 0.8813 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.3144 | 0.3144 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.3519 | 0.3993 |
Echinococcus multilocularis | protein patched | 0.0055 | 0.1074 | 0.1219 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0055 | 0.1074 | 0.1219 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0055 | 0.1074 | 0.1219 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0134 | 0.8813 | 1 |
Echinococcus granulosus | peroxidasin | 0.0076 | 0.3144 | 0.3567 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0134 | 0.8813 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0134 | 0.8813 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0076 | 0.3144 | 0.3567 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0055 | 0.1074 | 0.1219 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8813 | 0.8813 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0055 | 0.1074 | 0.1219 |
Brugia malayi | hypothetical protein | 0.0076 | 0.3144 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1074 | 0.1074 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.1074 | 0.1219 |
Onchocerca volvulus | 0.0146 | 1 | 1 | |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0134 | 0.8813 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0055 | 0.1074 | 0.1219 |
Brugia malayi | Peroxidasin | 0.0076 | 0.3144 | 0.3144 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0134 | 0.8813 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0134 | 0.8813 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0134 | 0.8813 | 0.8813 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0134 | 0.8813 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.