Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0192 | 0.4648 | 0.8118 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0192 | 0.4648 | 0.8105 |
Onchocerca volvulus | 0.0013 | 0.0041 | 1 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0192 | 0.4648 | 0.8105 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0399 | 1 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0013 | 0.0041 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0306 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0306 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0012 | 0.0005 |
Loa Loa (eye worm) | oxidoreductase | 0.0013 | 0.0041 | 0.0984 |
Trichomonas vaginalis | hypothetical protein | 0.0192 | 0.4648 | 0.4479 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.0306 | 0.0266 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0399 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0192 | 0.4648 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 0.0306 | 0.0294 |
Entamoeba histolytica | recQ family helicase, putative | 0.0023 | 0.0306 | 0.0306 |
Toxoplasma gondii | beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) | 0.0233 | 0.5725 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0041 | 0.0029 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0192 | 0.4648 | 0.8118 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0012 | 0.002 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0041 | 0.0029 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0012 | 0.0005 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.0306 | 0.0294 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.0306 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0041 | 0.0029 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0192 | 0.4648 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0306 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0306 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0012 | 0.0005 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0399 | 1 | 1 |
Chlamydia trachomatis | 3-hydroxyacyl-ACP dehydratase | 0.0233 | 0.5725 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0012 | 0.0005 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0041 | 0.0029 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0013 | 0.0041 | 0.0984 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0012 | 0.0005 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0399 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0399 | 1 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0399 | 1 | 1 |
Plasmodium vivax | beta-hydroxyacyl-ACP dehydratase precursor, putative | 0.0233 | 0.5725 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0306 | 0.0294 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0.0041 | 0.0029 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0012 | 0.0012 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0013 | 0.0041 | 0.0071 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0023 | 0.0306 | 0.0294 |
Onchocerca volvulus | 0.0013 | 0.0041 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0192 | 0.4648 | 0.8105 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0399 | 1 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0013 | 0.0041 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0041 | 0.0984 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0023 | 0.0306 | 0.0466 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0306 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.0306 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0013 | 0.0041 | 0.0041 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 0.0306 | 0.0294 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0012 | 0.002 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0306 | 0.0534 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0399 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | (3R)-hydroxymyristoyl-ACP dehydratase | 0.0233 | 0.5725 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.0306 | 0.0466 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0041 | 0.098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0012 | 0.0005 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0013 | 0.0041 | 0.0984 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0023 | 0.0306 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0023 | 0.0306 | 0.0294 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0041 | 0.098 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0013 | 0.0041 | 0.0071 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0306 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0013 | 0.0041 | 0.0029 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0012 | 0.0005 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0023 | 0.0306 | 0.0294 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0012 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0012 | 0.0005 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0192 | 0.4648 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0023 | 0.0306 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.00000000841 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Plasmodium falciparum | beta-hydroxyacyl-ACP dehydratase | 0.0233 | 0.5725 | 1 |
Giardia lamblia | Rrm3p helicase | 0.0399 | 1 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0013 | 0.0041 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0012 | 0.0005 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0399 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.