Detailed information for compound 942451

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.533 | Formula: C28H28N2O4
  • H donors: 0 H acceptors: 2 LogP: 4.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1C)C12N(CCN1C(=O)c1c2cccc1)C(=O)c1ccc(cc1)OC(C)C
  • InChi: 1S/C28H28N2O4/c1-18(2)34-22-13-10-20(11-14-22)26(31)29-15-16-30-27(32)23-7-5-6-8-24(23)28(29,30)21-12-9-19(3)25(17-21)33-4/h5-14,17-18H,15-16H2,1-4H3
  • InChiKey: YGHHCZASYCPQFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0129 0.1109 0.1694
Brugia malayi cathepsin B-like cysteine proteinase 0.053 0.6257 1
Echinococcus multilocularis Peptidase C54 0.0081 0.0482 0.0684
Brugia malayi calpain 5 0.0082 0.05 0.0784
Loa Loa (eye worm) hypothetical protein 0.0103 0.0776 0.1225
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.006 0.0217 0.0032
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0076 0.0423 0.1345
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0129 0.1109 0.0941
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0423 0.0612
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0192 0.1916 0.1764
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0129 0.1109 0.3055
Leishmania major hypothetical protein, conserved 0.0263 0.2832 0.2697
Toxoplasma gondii exonuclease 0.006 0.0213 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0328 0.3666 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0076 0.0423 0.1016
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0411 0.4727 0.4628
Trichomonas vaginalis calpain, putative 0.0226 0.2347 0.6404
Plasmodium vivax vivapain-3 0.0179 0.1752 0.4724
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0063 0.026 0.0657
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.043 0.0599
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.006 0.0217 0.0591
Plasmodium vivax calpain, putative 0.0327 0.3645 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0153 0.1416 0.1254
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0228 0.238 0.2236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma cruzi trypanothione synthetase 0.0066 0.0297 0.0114
Entamoeba histolytica calpain large subunit domain III containing protein 0.0082 0.05 0.1336
Plasmodium falciparum deubiquinating/deneddylating enzyme 0.0111 0.087 0.2379
Brugia malayi calpain 5 0.0226 0.2347 0.3741
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0063 0.026 0.0325
Schistosoma mansoni autophagin-1 (C54 family) 0.0081 0.0482 0.0709
Loa Loa (eye worm) hypothetical protein 0.0217 0.2236 0.3563
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0778 0.9455 0.9445
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.0423 0.066
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0422 0.4878 0.4782
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0226 0.2347 0.2203
Brugia malayi Cathepsin L-like precursor 0.032 0.3566 0.5692
Echinococcus multilocularis cathepsin l cysteine peptidase 0.032 0.3566 0.5659
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0552 0.654 0.6475
Giardia lamblia Hypothetical protein 0.0076 0.0423 0.1345
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0048 0.0058 0.0076
Leishmania major META domain containing protein 0.0263 0.2832 0.2697
Toxoplasma gondii cathepsin B 0.0258 0.2767 0.7741
Loa Loa (eye worm) calpain family protein 1 0.0286 0.312 0.4978
Echinococcus granulosus calpain 5 0.0308 0.3402 0.5394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0411 0.4727 0.4628
Entamoeba histolytica peptidase, C54 family 0.0192 0.1916 0.5338
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0057 0.0178 0.0426
Echinococcus multilocularis calpain 0.0308 0.3402 0.5394
Leishmania major calpain family cysteine protease-like protein 0.0556 0.6601 0.6537
Trypanosoma cruzi cysteine peptidase inhibitor 0.023 0.2401 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0423 0.1153
Leishmania major hypothetical protein, conserved 0.0066 0.0297 0.0114
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0564 0.6703 0.6641
Giardia lamblia Cathepsin L precursor 0.0076 0.0423 0.1345
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0111 0.087 0.2379
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0226 0.2347 0.6404
Giardia lamblia Hypothetical protein 0.0076 0.0423 0.1345
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0153 0.1416 0.3924
Loa Loa (eye worm) calpain 0.0339 0.3802 0.607
Leishmania major hypothetical protein, unknown function 0.066 0.793 0.7891
Giardia lamblia Cathepsin L precursor 0.0076 0.0423 0.1345
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0254 0.2716 0.2579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0423 0.1153
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0076 0.0423 0.0612
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.0123 0.1021 0.2786
Schistosoma mansoni cathepsin s 0.0103 0.0776 0.1181
Trypanosoma cruzi unspecified product 0.041 0.4721 0.4621
Entamoeba histolytica GPI-anchor transamidase, putative 0.006 0.0217 0.0535
Echinococcus multilocularis cathepsin L cysteine protease 0.032 0.3566 0.5659
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0226 0.2347 0.6404
Brugia malayi Cathepsin L-like precursor 0.032 0.3566 0.5692
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0259 0.2775 0.2638
Leishmania major hypothetical protein, conserved 0.0263 0.2832 0.2697
Schistosoma mansoni calpain C (C02 family) 0.0308 0.3402 0.5406
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0097 0.0694 0.0519
Leishmania major small myristoylated protein 4, putative 0.0612 0.7309 0.7258
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Schistosoma mansoni cathepsin F (C01 family) 0.0217 0.2236 0.353
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.238 0.2236
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Leishmania major trypanothione synthetase, putative 0.0066 0.0297 0.0114
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0066 0.0297 0.0114
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0058 0.0159
Trypanosoma brucei SUMO1/Ulp2, putative 0.0177 0.1719 0.1563
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.3645 0.3525
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0102 0.0755 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Entamoeba histolytica cysteine protease, putative 0.0076 0.0423 0.1117
Echinococcus granulosus cathepsin l cysteine peptidase 0.032 0.3566 0.5659
Giardia lamblia Cathepsin L precursor 0.0076 0.0423 0.1345
Brugia malayi CG8232-PA 0.0058 0.0196 0.0297
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.0423 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0493 0.5782 0.5702
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0058 0.0159
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0111 0.087 0.1309
Brugia malayi Papain family cysteine protease containing protein 0.0179 0.1752 0.2789
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0058 0.0076
Trypanosoma brucei antigen, putative 0.0308 0.3402 0.3277
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0063 0.026 0.0325
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.026 0.0657
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0357 0.4034 0.3921
Giardia lamblia GPI-anchor transamidase, putative 0.006 0.0217 0.0585
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0171 0.1644 0.2558
Echinococcus granulosus calpain A 0.0372 0.423 0.6731
Echinococcus multilocularis calpain 5 0.0308 0.3402 0.5394
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.053 0.6257 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.0423 0.0612
Leishmania major hypothetical protein, conserved 0.0263 0.2832 0.2697
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0079 0.0457 0.1214
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0058 0.0159
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.043 0.1172
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.007 0.0341 0.053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0423 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.2347 0.6404
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0074 0.0399 0.0549
Leishmania major hypothetical protein, conserved 0.0075 0.0411 0.0231
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.043 0.0624
Loa Loa (eye worm) fibroinase 0.032 0.3566 0.5692
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.1042 0.161
Brugia malayi calpain 7 0.0339 0.3802 0.607
Trypanosoma cruzi hypothetical protein, conserved 0.0328 0.3666 0.3547
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.043 0.0599
Giardia lamblia Cathepsin L precursor 0.0076 0.0423 0.1345
Trypanosoma brucei calpain, putative 0.0226 0.2347 0.2203
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0423 0.1153
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0063 0.026 0.0709
Loa Loa (eye worm) DOMON domain-containing protein 0.0046 0.0042 0.005
Echinococcus granulosus cathepsin L 0.0179 0.1752 0.2733
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Onchocerca volvulus 0.0205 0.2085 0.5798
Loa Loa (eye worm) hypothetical protein 0.0217 0.2236 0.3563
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0411 0.4727 0.4628
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0423 0.066
Schistosoma mansoni hypothetical protein 0.0075 0.0411 0.0594
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0254 0.2716 0.2579
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.238 0.2236
Entamoeba histolytica cysteine protease inhibitor 2 (EhICP2) 0.023 0.2401 0.6708
Echinococcus multilocularis protein will die slowly 0.0067 0.0312 0.0409
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0076 0.0423 0.1016
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0071 0.0365 0.0567
Loa Loa (eye worm) hypothetical protein 0.0075 0.0411 0.0641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.053 0.6257 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0192 0.1916 0.1764
Giardia lamblia Cathepsin B precursor 0.0258 0.2767 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0457 0.0277
Loa Loa (eye worm) hypothetical protein 0.0076 0.0423 0.066
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.043 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0258 0.2767 0.7547
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0422 0.1152
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0423 0.1153
Plasmodium falciparum serine repeat antigen 9 0.0076 0.0423 0.1117
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0076 0.0423 0.1153
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0097 0.0694 0.1026
Echinococcus granulosus GPI anchor transamidase 0.006 0.0217 0.0256
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0357 0.4034 0.3921
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.2832 0.2697
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0493 0.5782 0.5702
Loa Loa (eye worm) TK/ROR protein kinase 0.0075 0.0411 0.0641
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0423 0.1153
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0228 0.238 0.2236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0564 0.6703 0.6641
Echinococcus granulosus cathepsin L cysteine proteinase 0.032 0.3566 0.5659
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.043 0.0671
Brugia malayi Papain family cysteine protease containing protein 0.032 0.3566 0.5692
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0821 1 1
Trypanosoma brucei otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0531 0.0352
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0048 0.0058 0.0087
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0076 0.0423 0.0612
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0569 0.6766 0.6705
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0185 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.032 0.3566 0.9727
Toxoplasma gondii cathepsin CPC2 0.0076 0.0423 0.1117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase BAP1 0.0061 0.0224 0.0267
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0185 0.0204
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.032 0.3566 0.5692
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0111 0.087 0.0697
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0263 0.2832 0.2697
Brugia malayi cathepsin L-like precursor 0.0217 0.2236 0.3563
Loa Loa (eye worm) hypothetical protein 0.0205 0.2085 0.3321
Echinococcus multilocularis cathepsin b 0.053 0.6257 1
Plasmodium falciparum serine repeat antigen 4 0.0076 0.0423 0.1117
Leishmania major cathepsin L-like protease 0.032 0.3566 0.3445
Plasmodium falciparum serine repeat antigen 8 0.0076 0.0423 0.1117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.0457 0.1247
Toxoplasma gondii cathepsin CPL 0.032 0.3566 1
Giardia lamblia Cathepsin B precursor 0.0076 0.0423 0.1345
Trypanosoma brucei small myristoylated protein 1-2 0.041 0.4721 0.4621
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0423 0.1153
Loa Loa (eye worm) hypothetical protein 0.0205 0.2085 0.3321
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0129 0.1109 0.3024
Leishmania major cysteine peptidase A (CPA) 0.032 0.3566 0.3445
Trypanosoma brucei Calpain-like protein 2 0.0612 0.732 0.7269
Leishmania major trypanothione synthetase, putative 0.0066 0.0297 0.0114
Trypanosoma brucei unspecified product 0.0263 0.2832 0.2697
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0129 0.1109 0.1716
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0102 0.0755 0.0581
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0163 0.1543 0.1383
Giardia lamblia Cysteine protease 0.0076 0.0423 0.1345
Echinococcus granulosus Ubiquitin thioesterase otubain protein 0.0084 0.0531 0.0762
Trypanosoma cruzi small myristoylated protein 1-2 0.041 0.4721 0.4621
Trichomonas vaginalis calpain, putative 0.0226 0.2347 0.6404
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0569 0.6766 0.6705
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0564 0.6703 0.6641
Trypanosoma brucei calpain-like protein, putative 0.0327 0.3645 0.3525
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0273 0.296 0.2827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1752 0.4781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0103 0.0776 0.1225
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0123 0.1021 0.1553
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0071 0.0365 0.0494
Loa Loa (eye worm) papain family cysteine protease containing protein 0.032 0.3566 0.5692
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0076 0.0423 0.1117
Trypanosoma cruzi cysteine peptidase, putative 0.0103 0.0776 0.0602
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1752 0.4875
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0076 0.0423 0.1345
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0263 0.2832 0.2697
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0048 0.0058 0.0026
Trypanosoma brucei calpain-like protein, putative 0.0327 0.3645 0.3525
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.007 0.0341 0.0457
Mycobacterium ulcerans hypothetical protein 0.0097 0.0697 0.5
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0076 0.0423 0.1016
Loa Loa (eye worm) cysteine protease 0.032 0.3566 0.5692
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0482 0.1316
Giardia lamblia Encystation-specific protease 0.0076 0.0423 0.1345
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0076 0.0423 0.1016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0071 0.0365 0.0995
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.2747 0.2611
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.053 0.6257 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0076 0.0423 0.1117
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0111 0.087 0.1309
Trypanosoma brucei cysteine peptidase, putative 0.0569 0.6766 0.6705
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.007 0.0341 0.0887
Plasmodium falciparum cysteine proteinase falcipain 1 0.0179 0.1752 0.4875
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0821 1 1
Trypanosoma cruzi cysteine protease, putative 0.0179 0.1752 0.1597
Echinococcus multilocularis cysteine protease atg4b 0.0081 0.0482 0.0684
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0411 0.0231
Toxoplasma gondii preprocathepsin c precursor, putative 0.0076 0.0423 0.1117
Leishmania major kinesin, putative 0.0082 0.05 0.0321
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.043 0.0249
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0076 0.0423 0.1117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0778 0.9455 0.9445
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0493 0.5782 0.5702
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0153 0.1416 0.1254
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0097 0.0694 0.1894
Plasmodium falciparum cysteine repeat modular protein 1 0.0075 0.0411 0.1085
Echinococcus multilocularis calpain family protein 1, d 0.0286 0.312 0.4939
Loa Loa (eye worm) hypothetical protein 0.007 0.0341 0.053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0423 0.066
Loa Loa (eye worm) hypothetical protein 0.0217 0.2236 0.3563
Echinococcus granulosus tissue type plasminogen activator 0.0075 0.0411 0.0569
Echinococcus granulosus cathepsin b 0.053 0.6257 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0192 0.1916 0.1764
Brugia malayi ubiquitin specific protease 14 0.007 0.0341 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0076 0.0423 0.1153
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0207 0.211 0.1961
Giardia lamblia Cathepsin B precursor 0.0258 0.2767 1
Giardia lamblia Cysteine protease 0.0076 0.0423 0.1345
Onchocerca volvulus 0.032 0.3566 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0482 0.1316
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0482 0.1316
Loa Loa (eye worm) calpain 5 0.0082 0.05 0.0784
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0079 0.0457 0.0277
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.0423 0.066
Onchocerca volvulus 0.032 0.3566 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0179 0.1752 0.1597
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0423 0.066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0297 0.0114
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.043 0.0599
Giardia lamblia Cathepsin L precursor 0.0076 0.0423 0.1345
Loa Loa (eye worm) hypothetical protein 0.006 0.0218 0.0332
Plasmodium falciparum serine repeat antigen 2 0.0076 0.0423 0.1117
Onchocerca volvulus 0.032 0.3566 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0179 0.1752 0.2752
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0178 0.0487
Onchocerca volvulus 0.0217 0.2236 0.6226
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0102 0.0755 0.1148
Trypanosoma brucei Calpain-like protein 1.2 0.063 0.7544 0.7498
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Echinococcus granulosus cysteine protease atg4b 0.0081 0.0482 0.0684
Loa Loa (eye worm) hypothetical protein 0.0084 0.0531 0.0832
Trypanosoma cruzi cruzipain precursor, putative 0.0103 0.0776 0.0602
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0102 0.0755 0.0581
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0422 0.1152
Loa Loa (eye worm) hypothetical protein 0.053 0.6257 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.063 0.7544 0.7498
Entamoeba histolytica hypothetical protein 0.0076 0.0423 0.1117
Toxoplasma gondii cathepsin CPC1 0.0076 0.0423 0.1117
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0063 0.026 0.0399
Trypanosoma brucei CHAP domain containing protein, putative 0.0066 0.0297 0.0114
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0263 0.2832 0.2697
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0076 0.0423 0.1153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.1752 0.4781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0102 0.0755 0.1192
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0048 0.0058 0.0076
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.0123 0.1021 0.2786
Trypanosoma brucei small myristoylated protein 1-1 0.041 0.4721 0.4621
Echinococcus multilocularis calpain 7 (C02 family) 0.0339 0.3802 0.604
Loa Loa (eye worm) ubiquitin C-terminal hydrolase UCH-L5 0.0111 0.087 0.1375
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0061 0.0224 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0257 0.2747 0.2611
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.032 0.3566 0.9727
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.007 0.0342 0.016
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.043 0.0599
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0123 0.1021 0.1575
Brugia malayi Papain family cysteine protease containing protein 0.0179 0.1752 0.2789
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0171 0.1644 0.4545
Loa Loa (eye worm) hypothetical protein 0.0103 0.0776 0.1225
Schistosoma mansoni cathepsin F (C01 family) 0.032 0.3566 0.567
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.063 0.7544 0.7498
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0423 0.0612
Giardia lamblia Cysteine protease 0.0076 0.0423 0.1345
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0097 0.0694 0.0519
Toxoplasma gondii kringle domain-containing protein 0.0075 0.0411 0.1085
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0079 0.0457 0.0668
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0342 0.016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0076 0.0422 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0349 0.3934 0.382
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0489 0.5733 0.5653
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0245 0.2591 0.7244
Plasmodium falciparum serine repeat antigen 7 0.0076 0.0423 0.1117
Trypanosoma cruzi trypanothione synthetase, putative 0.0066 0.0297 0.0114
Echinococcus granulosus Peptidase C54 0.0081 0.0482 0.0684
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0076 0.0422 0.1114
Leishmania major otubain, putative,otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0531 0.0352
Onchocerca volvulus 0.006 0.0218 0.05
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0123 0.1021 0.0852
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0228 0.238 0.2236
Entamoeba histolytica protein kinase, putative 0.0082 0.05 0.1336
Loa Loa (eye worm) hypothetical protein 0.032 0.3566 0.5692
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.007 0.0341 0.0482
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0263 0.2832 0.2697
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0123 0.1021 0.0852
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0058 0.0087
Trypanosoma brucei trypanothione synthetase 0.0066 0.0297 0.0114
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0123 0.1021 0.0852
Plasmodium vivax vivapain-2 0.032 0.3566 0.978
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.238 0.2236
Echinococcus multilocularis Ubiquitin thioesterase otubain protein 0.0084 0.0531 0.0762
Plasmodium vivax vivapain-1 0.0179 0.1752 0.4724
Brugia malayi Cathepsin L-like precursor 0.032 0.3566 0.5692
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0071 0.0365 0.0494
Trypanosoma brucei calpain, putative 0.0482 0.5649 0.5567
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0349 0.3934 0.382
Entamoeba histolytica cysteine protease, putative 0.0076 0.0423 0.1117
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.0111 0.087 0.0697
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase UCHL3 0.0123 0.1021 0.2808
Onchocerca volvulus Cathepsin L homolog 0.032 0.3566 1
Echinococcus multilocularis cathepsin L cysteine protease 0.032 0.3566 0.5659
Leishmania major cathepsin L-like protease 0.032 0.3566 0.3445
Leishmania major trypanothione synthetase-like protein 0.0066 0.0297 0.0114
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0595 0.7099 0.7044
Trypanosoma brucei inhibitor of cysteine peptidase 0.023 0.2401 0.2258
Brugia malayi Cathepsin L-like cysteine proteinase 0.0217 0.2236 0.3563
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.043 0.1371
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.043 0.0599
Brugia malayi calpain family protein 1 0.0368 0.4174 0.6666
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0356 0.4021 0.3908
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0258 0.2767 0.263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Brugia malayi Cathepsin L-like precursor 0.0217 0.2236 0.3563
Brugia malayi Cathepsin L-like precursor 0.0217 0.2236 0.3563
Loa Loa (eye worm) cathepsin B 0.0258 0.2767 0.4412
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0569 0.6766 0.6705
Leishmania major small myristoylated protein-3, putative 0.0357 0.4034 0.3921
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0564 0.6703 0.6641
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0391 0.4477 0.4373
Entamoeba histolytica hypothetical protein 0.0061 0.0224 0.0555
Leishmania major hypothetical protein, conserved 0.0263 0.2832 0.2697
Entamoeba histolytica cysteine proteinase, putative 0.032 0.3566 1
Loa Loa (eye worm) WD40 repeat protein 0.0067 0.0312 0.0482
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0111 0.087 0.1331
Schistosoma mansoni cathepsin B (C01 family) 0.0076 0.0423 0.0612
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.2747 0.2611
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0129 0.1109 0.0941
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0431 0.4988 0.4894
Schistosoma mansoni calpain-7 (C02 family) 0.0382 0.4356 0.6942
Toxoplasma gondii hypothetical protein 0.0226 0.2347 0.6556
Trypanosoma cruzi trypanothione synthetase, putative 0.0066 0.0297 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0328 0.3666 0.3547
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0057 0.0178 0.0487
Echinococcus granulosus calpain A 0.0308 0.3402 0.5394
Leishmania major cathepsin L-like protease 0.032 0.3566 0.3445
Trypanosoma brucei glutathionylspermidine synthetase, putative 0.0066 0.0297 0.0114
Trichomonas vaginalis calpain, putative 0.0226 0.2347 0.6404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0423 0.1153
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.238 0.2236
Schistosoma mansoni cathepsin F (C01 family) 0.032 0.3566 0.567
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0423 0.0612
Echinococcus multilocularis cathepsin L 0.0076 0.0423 0.0588
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0598 0.714 0.7086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.0272 0.0742
Loa Loa (eye worm) hypothetical protein 0.0142 0.1273 0.202
Schistosoma mansoni calpain (C02 family) 0.0308 0.3402 0.5406
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1752 0.4875
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0071 0.0365 0.0183
Echinococcus multilocularis cathepsin b 0.053 0.6257 1
Giardia lamblia Cathepsin L-like protease 0.0076 0.0423 0.1345
Onchocerca volvulus Cathepsin F homolog 0.032 0.3566 1
Trichomonas vaginalis ubiquitin specific protease, putative 0.0062 0.0244 0.0665
Entamoeba histolytica peptidase, C54 family 0.0081 0.0482 0.1286
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0357 0.4034 0.3921
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase isozyme L3, putative 0.0123 0.1021 0.2685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Trypanosoma cruzi kinesin, putative 0.0082 0.05 0.0321
Leishmania major calpain protease-like protein 0.0257 0.2748 0.2611
Plasmodium falciparum serine repeat antigen 6 0.0076 0.0423 0.1117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0129 0.1109 0.3024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.2767 0.4384
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.007 0.0341 0.0457
Leishmania major PFPI/DJ-1-like protein, putative 0.0443 0.5148 0.5057
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0372 0.423 0.6739
Entamoeba histolytica cysteine protease, putative 0.0076 0.0423 0.1117
Loa Loa (eye worm) hypothetical protein 0.0076 0.0423 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0076 0.0422 0.0587
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0368 0.4174 0.6649
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0076 0.0422 0.0658
Trypanosoma cruzi small myristoylated protein 1-1 0.041 0.4721 0.4621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma brucei cysteine peptidase C (CPC) 0.0258 0.2767 0.263
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0342 0.016
Brugia malayi Sex muscle abnormal protein 5 0.0124 0.1042 0.1652
Plasmodium falciparum serine repeat antigen 3 0.0076 0.0423 0.1117
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0071 0.0365 0.0519
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0254 0.2716 0.2579
Leishmania major cathepsin L-like protease 0.032 0.3566 0.3445
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase isozyme L3 0.0123 0.1021 0.2808
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.0423 0.1016
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0778 0.9455 0.9445
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0423 0.1153
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0177 0.1719 0.1563
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0063 0.026 0.035
Entamoeba histolytica cysteine proteinase 1, putative 0.0179 0.1752 0.4875
Schistosoma mansoni ubiquitinyl hydrolase-BAP1 (C12 family) 0.0061 0.0224 0.0293
Trypanosoma brucei trypanothione synthetase, putative 0.0066 0.0297 0.0114
Onchocerca volvulus Cathepsin L homolog 0.0076 0.0423 0.108
Loa Loa (eye worm) hypothetical protein 0.0051 0.0096 0.0136
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Trypanosoma brucei hypothetical protein 0.0482 0.5649 0.5567
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0171 0.1644 0.2577
Leishmania major inhibitor of cysteine peptidase 0.023 0.2401 0.2258
Trypanosoma cruzi cysteine peptidase, putative 0.0459 0.5351 0.5263
Plasmodium vivax GPI-anchor transamidase, putative 0.006 0.0217 0.0442
Plasmodium falciparum GPI-anchor transamidase, putative 0.006 0.0217 0.0535
Entamoeba histolytica cysteine proteinase, putative 0.032 0.3566 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.043 0.1136
Loa Loa (eye worm) calpain family protein 1 0.0368 0.4174 0.6666
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0612 0.732 0.7269
Plasmodium falciparum serine repeat antigen 5 0.0076 0.0423 0.1117
Loa Loa (eye worm) hypothetical protein 0.0081 0.0482 0.0755
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0422 0.1152
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.006 0.0217 0.0591
Onchocerca volvulus 0.0051 0.0096 0.0152
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.238 0.2236
Echinococcus granulosus calpain 0.0308 0.3402 0.5394
Loa Loa (eye worm) hypothetical protein 0.0058 0.0196 0.0297
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.006 0.0217 0.0032
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0177 0.1719 0.1563
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Giardia lamblia Cathepsin B precursor 0.0076 0.0423 0.1345
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0081 0.0482 0.0709
Echinococcus multilocularis tissue type plasminogen activator 0.0075 0.0411 0.0569
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0207 0.211 0.1961
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0071 0.0365 0.0567
Brugia malayi Peptidase family C54 containing protein 0.0081 0.0482 0.0755
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0076 0.0423 0.1153
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Schistosoma mansoni hypothetical protein 0.0067 0.0312 0.0434
Trypanosoma brucei amidase, putative 0.0066 0.0297 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0423 0.1153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0207 0.211 0.1961
Giardia lamblia Cathepsin B precursor 0.0076 0.0423 0.1345
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0048 0.0058 0.0087
Echinococcus granulosus cathepsin L cysteine protease 0.0179 0.1752 0.2733
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0652 0.783 0.7789
Giardia lamblia Cathepsin B precursor 0.0076 0.0423 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0423 0.1153
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0482 0.5649 0.5567
Trypanosoma cruzi cysteine peptidase, putative 0.0179 0.1752 0.1597
Echinococcus granulosus cathepsin b 0.053 0.6257 1
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0048 0.0058 0.0026
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0185 0.023
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0103 0.0776 0.1225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0431 0.4988 0.4894
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0821 1 1
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0071 0.0365 0.0183
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0129 0.1109 0.0941
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0129 0.1109 0.0941
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0081 0.0482 0.0303
Entamoeba histolytica cysteine proteinase 2 0.0179 0.1752 0.4875
Plasmodium vivax ubiquitin C-terminal hydrolase, family 1, putative 0.0111 0.087 0.2262
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0482 0.1316
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0423 0.0612
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0097 0.0694 0.105
Trypanosoma brucei conserved protein 0.0211 0.2162 0.2015
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0192 0.1916 0.1764
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0564 0.6703 0.6641
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.238 0.2236
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0218 0.2243 0.3542
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.026 0.0076
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0076 0.0423 0.1117
Brugia malayi Kringle domain containing protein 0.0075 0.0411 0.0641
Loa Loa (eye worm) hypothetical protein 0.0368 0.4174 0.6666
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0063 0.026 0.0325
Brugia malayi cathepsin F-like cysteine proteinase 0.0103 0.0776 0.1225
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0097 0.0694 0.0519
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.043 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0063 0.026 0.0562
Trichomonas vaginalis hypothetical protein 0.0226 0.2347 0.6404
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.043 0.1172
Trypanosoma brucei calpain-like protein, putative 0.0308 0.3402 0.3277
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0564 0.6703 0.6641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0076 0.0422 0.1342
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0048 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0076 0.043 0.0671
Echinococcus multilocularis cathepsin l cysteine peptidase 0.032 0.3566 0.5659
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0457 0.0277
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0489 0.5733 0.5653
Entamoeba histolytica calpain family cysteine protease, putative 0.0293 0.3215 0.9009
Echinococcus granulosus cysteine protease 0.0179 0.1752 0.2733
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.026 0.0076
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0111 0.087 0.1331
Leishmania major cathepsin L-like protease 0.032 0.3566 0.3445
Plasmodium falciparum cysteine proteinase falcipain 2a 0.032 0.3566 1
Onchocerca volvulus 0.0067 0.0312 0.0766
Echinococcus multilocularis calpain A 0.0372 0.423 0.6731
Trypanosoma brucei kinesin, putative 0.0082 0.05 0.0321
Trypanosoma cruzi cysteine peptidase inhibitor, putative 0.023 0.2401 0.2258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0111 0.087 0.0697
Brugia malayi Protein kinase domain containing protein 0.0075 0.0411 0.0641
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0205 0.2085 0.3288
Trypanosoma cruzi otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0531 0.0352
Echinococcus granulosus cathepsin l1 0.0217 0.2236 0.3513
Leishmania major hypothetical protein, conserved 0.0437 0.5064 0.4971
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0081 0.0482 0.1316
Trypanosoma cruzi cysteine peptidase, putative 0.0459 0.5351 0.5263
Plasmodium vivax unspecified product 0.0076 0.0423 0.1016
Loa Loa (eye worm) calpain D 0.0293 0.3215 0.513
Echinococcus multilocularis cysteine protease 0.032 0.3566 0.5659
Trypanosoma cruzi cysteine peptidase, putative 0.0459 0.5351 0.5263
Giardia lamblia Cysteine protease 0.0076 0.0423 0.1345
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0185 0.0445
Schistosoma mansoni otubain-1 (C65 family) 0.0084 0.0531 0.0786
Schistosoma mansoni cathepsin C 0.0076 0.0423 0.0612
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0153 0.1416 0.1254
Leishmania major small myristoylated protein-1 0.041 0.4721 0.4621
Brugia malayi cathepsin F-like cysteine proteinase 0.0076 0.0423 0.066
Brugia malayi Cathepsin L-like precursor 0.032 0.3566 0.5692
Loa Loa (eye worm) hypothetical protein 0.007 0.0342 0.053
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0652 0.783 0.7789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0423 0.1153
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Trypanosoma brucei calpain-like protein, putative 0.0564 0.6703 0.6641
Brugia malayi Ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.0123 0.1021 0.1618
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0327 0.3645 0.3525
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0422 0.0658
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.007 0.0342 0.0888
Trypanosoma cruzi major cysteine proteinase, putative 0.0215 0.2207 0.2061
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0124 0.1042 0.1652
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.066 0.793 0.7891
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0079 0.0457 0.1214
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.063 0.7544 0.7498
Entamoeba histolytica cysteine protease, putative 0.032 0.3566 1
Brugia malayi Trypsin family protein 0.0205 0.2085 0.3321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0423 0.1153
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0081 0.0482 0.0303
Giardia lamblia Cathepsin L-like protease 0.0076 0.0423 0.1345
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.2832 0.2697
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.2832 0.2697
Onchocerca volvulus 0.0075 0.0411 0.1048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0042 0.005
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0423 0.066
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0076 0.0423 0.1016
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0273 0.296 0.2827
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.007 0.0341 0.0932
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0207 0.211 0.1961
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.043 0.0249
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.007 0.0341 0.1045
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0228 0.238 0.2236
Schistosoma mansoni hypothetical protein 0.0226 0.2347 0.3709
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0076 0.0423 0.1345
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0057 0.0178 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma cruzi cysteine peptidase, putative 0.032 0.3566 0.3445
Leishmania major cathepsin L-like protease 0.0459 0.5351 0.5263
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0422 0.4878 0.4782
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0097 0.0694 0.1095
Entamoeba histolytica cysteine protease inhibitor 1 (EhICP1) 0.023 0.2401 0.6708
Echinococcus multilocularis hypothetical protein 0.0308 0.3402 0.5394
Brugia malayi prolyl oligopeptidase family protein 0.0171 0.1644 0.2614
Brugia malayi Will die slowly protein 0.0067 0.0312 0.0482
Toxoplasma gondii ubiquitin thioesterase otubain-like family protein 0.0084 0.0531 0.1422
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.0423 0.0612
Trypanosoma brucei Calpain-like protein CALP1.3 0.0489 0.5733 0.5653
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0226 0.2347 0.6404
Trypanosoma cruzi otubain cysteine peptidase, Clan CA, family C65, putative 0.0084 0.0531 0.0352
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0258 0.2767 0.263
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0076 0.0423 0.1345
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase family 2, putative 0.0078 0.0451 0.1093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1752 0.1597
Leishmania major cathepsin L-like protease 0.0459 0.5351 0.5263
Echinococcus multilocularis GPI anchor transamidase 0.006 0.0217 0.0256
Trypanosoma cruzi kinesin, putative 0.0082 0.05 0.0321
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0263 0.2832 0.2697
Loa Loa (eye worm) hypothetical protein 0.0076 0.0423 0.066
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.1042 0.161
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0177 0.1719 0.1563
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0226 0.2347 0.6404
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0226 0.2347 0.6404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0179 0.1752 0.1597
Brugia malayi fibroinase precursor 0.0076 0.0423 0.066
Schistosoma mansoni cathepsin S (C01 family) 0.0076 0.0423 0.0612
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0357 0.4034 0.3921
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0063 0.026 0.0657
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0228 0.238 0.2236
Trypanosoma cruzi conserved protein 0.0437 0.5064 0.4971
Trypanosoma cruzi major cysteine proteinase, putative 0.0076 0.0423 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0153 0.1416 0.1254
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0171 0.1644 0.2558
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0263 0.2832 0.2697
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0422 0.4878 0.4782
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0482 0.5649 0.5567
Plasmodium vivax unspecified product 0.0179 0.1752 0.4724
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0564 0.6703 0.6641
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.006 0.0217 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Trypanosoma cruzi trypanothione synthetase-like protein, putative 0.0066 0.0297 0.0114
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0263 0.2832 0.2697
Brugia malayi SEA domain containing protein 0.0046 0.0042 0.005
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.043 0.0249
Onchocerca volvulus 0.032 0.3566 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.043 0.1172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0081 0.0482 0.0709
Echinococcus granulosus cathepsin L 0.0076 0.0423 0.0588
Trypanosoma cruzi ubiquitin hydrolase, putative 0.006 0.0213 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1752 0.4875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Plasmodium falciparum cysteine proteinase falcipain 2b 0.032 0.3566 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0423 0.1153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Brugia malayi cathepsin L-like cysteine proteinase 0.0076 0.0423 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.2236 0.61
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0552 0.654 0.6475
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0372 0.423 0.6731
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.006 0.0217 0.0591
Leishmania major hypothetical protein, conserved 0.0263 0.2832 0.2697
Brugia malayi ubiquitin C-terminal hydrolase UCH-L5 0.0111 0.087 0.1375
Echinococcus granulosus cathepsin l1 0.032 0.3566 0.5659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.032 0.3566 0.9727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0423 0.1153
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0598 0.714 0.7086
Plasmodium falciparum serine repeat antigen 1 0.0076 0.0423 0.1117
Entamoeba histolytica cysteine protease, putative 0.0076 0.0423 0.1117
Toxoplasma gondii peptidase c13 family protein 0.006 0.0217 0.0535
Entamoeba histolytica cysteine proteinase, putative 0.0217 0.2236 0.6242
Entamoeba histolytica cysteine protease, putative 0.0076 0.0423 0.1117
Giardia lamblia Cathepsin B precursor 0.0258 0.2767 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0123 0.1021 0.1553
Onchocerca volvulus 0.0173 0.1674 0.463
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0431 0.4988 0.4894
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0058 0.0159
Plasmodium vivax vivapain-2 0.032 0.3566 0.978
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0652 0.783 0.7789
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0111 0.087 0.1309
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0411 0.4727 0.4628
Trypanosoma brucei hypothetical protein, conserved 0.0328 0.3666 0.3547
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0076 0.0423 0.066
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.0423 0.1016
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0179 0.1752 0.2752
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0102 0.0755 0.1125
Loa Loa (eye worm) ctsf protein 0.032 0.3566 0.5692
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.053 0.6257 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0257 0.2747 0.2611
Brugia malayi Cathepsin L-like precursor 0.032 0.3566 0.5692
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.0423 0.1016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0821 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0124 0.1042 0.1588
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0263 0.2832 0.2697
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0076 0.0423 0.1016
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0076 0.0423 0.1016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase BAP1 0.0061 0.0224 0.0267
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0076 0.0423 0.066
Brugia malayi calpain D 0.0293 0.3215 0.513
Loa Loa (eye worm) hypothetical protein 0.0226 0.2347 0.3741
Trypanosoma cruzi trypanothione synthetase 0.0066 0.0297 0.0114
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0821 1 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0372 0.423 0.6731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Onchocerca volvulus 0.0076 0.0423 0.108
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0226 0.2347 0.6404
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Entamoeba histolytica cysteine protease, putative 0.0179 0.1752 0.4875
Leishmania major hypothetical protein, conserved 0.0328 0.3666 0.3547
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0399 0.0218
Loa Loa (eye worm) hypothetical protein 0.0286 0.312 0.4978
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0254 0.2716 0.2579
Trichomonas vaginalis WD repeat domain, putative 0.0067 0.0312 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0228 0.238 0.2236
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0071 0.0365 0.0183
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.2747 0.2611
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0058 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0217 0.2236 0.61
Brugia malayi cathepsin L precursor 0.0076 0.0423 0.066
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.006 0.0217 0.0281
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0307 0.3391 0.3266
Plasmodium falciparum calpain 0.0245 0.2591 0.7244
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0076 0.0423 0.1016
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0391 0.4477 0.4373
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0063 0.026 0.0076
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.0423 0.066
Brugia malayi calpain family protein 1 0.0368 0.4174 0.6666
Loa Loa (eye worm) hypothetical protein 0.0103 0.0776 0.1225
Echinococcus granulosus growth factor receptor bound protein 2 0.0124 0.1042 0.1588
Loa Loa (eye worm) hypothetical protein 0.006 0.0217 0.033
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0569 0.6766 0.6705
Echinococcus multilocularis cathepsin L 0.0179 0.1752 0.2733
Trypanosoma cruzi cruzipain precursor, putative 0.0459 0.5351 0.5263
Trypanosoma cruzi cysteine proteinase, putative 0.0179 0.1752 0.1597
Giardia lamblia Cathepsin L precursor 0.0076 0.0423 0.1345
Echinococcus granulosus calpain 7 C02 family 0.0339 0.3802 0.604
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0123 0.1021 0.1575
Schistosoma mansoni calpain-7 (C02 family) 0.0382 0.4356 0.6942
Loa Loa (eye worm) hypothetical protein 0.0076 0.0423 0.066
Onchocerca volvulus 0.032 0.3566 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0111 0.087 0.2379
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0569 0.6766 0.6705
Giardia lamblia Cathepsin B precursor 0.0076 0.0423 0.1345
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0079 0.0457 0.0643
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0372 0.423 0.6739
Echinococcus granulosus protein will die slowly 0.0067 0.0312 0.0409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma cruzi cysteine proteinase, putative 0.0179 0.1752 0.1597
Leishmania major receptor-type adenylate cyclase a-like protein 0.0263 0.2832 0.2697
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0598 0.714 0.7086
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0102 0.0755 0.1192
Brugia malayi Cathepsin L-like precursor 0.0103 0.0776 0.1225
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.2832 0.2697
Schistosoma mansoni Mername-AA248 (C02 family) 0.0308 0.3402 0.5406
Brugia malayi Cathepsin L-like precursor 0.032 0.3566 0.5692
Trypanosoma brucei cysteine peptidase, Clan CA, family C19, putative 0.0102 0.0755 0.0581
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0063 0.026 0.0076
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0102 0.0755 0.1125
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0821 1 1
Onchocerca volvulus Cathepsin L homolog 0.032 0.3566 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0097 0.0694 0.1095
Schistosoma mansoni calpain-2 (C02 family) 0.0226 0.2347 0.3709
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0179 0.1752 0.2752
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.043 0.0599
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0422 0.4878 0.4782
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0081 0.0482 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.2747 0.2611
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.1752 0.4875
Brugia malayi Muscle positioning protein 4 0.0051 0.0096 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0357 0.4034 0.3921
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0076 0.0423 0.1117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Leishmania major hypothetical protein, conserved 0.0263 0.2832 0.2697
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0489 0.5733 0.5653
Leishmania major cathepsin L-like protease 0.0459 0.5351 0.5263
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0423 0.0612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0423 0.1153
Loa Loa (eye worm) prolyl oligopeptidase 0.0171 0.1644 0.2614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0342 0.079
Onchocerca volvulus 0.032 0.3566 1
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.0123 0.1021 0.1575
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.0423 0.1016
Echinococcus granulosus ubiquitin specific peptidase c family 0.0129 0.1109 0.1694
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0075 0.0411 0.0984
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.0272 0.0742
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0411 0.4727 0.4628
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0076 0.0422 0.1014
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0063 0.026 0.0325
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0063 0.026 0.0709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.032 0.3566 0.9727
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.0272 0.0742
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.006 0.0213 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Trypanosoma brucei Calpain-like protein 1.1 0.0821 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.053 0.6257 0.6186
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.066 0.793 0.7891
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0071 0.0365 0.0183
Echinococcus multilocularis cysteine protease 0.032 0.3566 0.5659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0459 0.5351 0.5263
Onchocerca volvulus 0.032 0.3566 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.007 0.0342 0.016
Loa Loa (eye worm) hypothetical protein 0.0123 0.1021 0.1618
Brugia malayi GPI-anchor transamidase 0.006 0.0217 0.033
Entamoeba histolytica cysteine protease, putative 0.0076 0.0423 0.1117
Leishmania major small myristoylated protein-2 0.0698 0.8415 0.8385
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0185 0.0204
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0612 0.7309 0.7258
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0097 0.0694 0.1026
Plasmodium falciparum cysteine proteinase falcipain 3 0.032 0.3566 1
Plasmodium vivax unspecified product 0.0103 0.0776 0.2

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.2 uM Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay ChEMBL. 25542588

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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