Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Onchocerca volvulus | 0.043 | 0.1109 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.043 | 0.1109 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.0886 | 0.0188 |
Schistosoma mansoni | acetylcholinesterase | 0.043 | 0.1109 | 0.1109 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.043 | 0.1109 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.0886 | 0.0188 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.043 | 0.1109 | 0.1109 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0377 | 0.0886 | 0.0886 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.043 | 0.1109 | 0.1109 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1109 | 0.0245 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.043 | 0.1109 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.043 | 0.1109 | 0.1109 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.043 | 0.1109 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.2545 | 1 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0461 | 0.124 | 0.124 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0461 | 0.124 | 0.124 |
Onchocerca volvulus | 0.043 | 0.1109 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.043 | 0.1109 | 0.1109 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.043 | 0.1109 | 0.1109 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.043 | 0.1109 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1109 | 0.0245 |
Loa Loa (eye worm) | carboxylesterase | 0.043 | 0.1109 | 0.0428 |
Onchocerca volvulus | 0.043 | 0.1109 | 1 | |
Brugia malayi | hypothetical protein | 0.043 | 0.1109 | 0.0245 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.043 | 0.1109 | 0.1109 |
Loa Loa (eye worm) | carboxylesterase | 0.043 | 0.1109 | 0.0428 |
Schistosoma mansoni | gliotactin | 0.043 | 0.1109 | 0.1109 |
Echinococcus multilocularis | acetylcholinesterase | 0.2545 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.043 | 0.1109 | 0.1109 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.043 | 0.1109 | 0.1109 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.043 | 0.1109 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2545 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.043 | 0.1109 | 0.1109 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2545 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2545 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2545 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2545 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.043 | 0.1109 | 0.1109 |
Echinococcus granulosus | acetylcholinesterase | 0.2545 | 1 | 1 |
Onchocerca volvulus | 0.043 | 0.1109 | 1 | |
Echinococcus multilocularis | neuropeptide s receptor | 0.0461 | 0.124 | 0.124 |
Echinococcus multilocularis | acetylcholinesterase | 0.2545 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0461 | 0.124 | 0.124 |
Onchocerca volvulus | 0.043 | 0.1109 | 1 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0377 | 0.0886 | 0.0886 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1109 | 0.0245 |
Echinococcus granulosus | neuroligin | 0.043 | 0.1109 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.1109 | 0.0428 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.043 | 0.1109 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2545 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.043 | 0.1109 | 0.0245 |
Echinococcus multilocularis | neuroligin | 0.043 | 0.1109 | 0.1109 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2545 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2545 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 14 nM | Agonist activity at human recombinant CB2 receptor expressing CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | ChEMBL. | 25575658 |
EC50 (functional) | = 13000 nM | Agonist activity at human recombinant CB1 receptor expressing CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | ChEMBL. | 25575658 |
T1/2 (ADMET) | = 5 min | Half life in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS method | ChEMBL. | 25575658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.