Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.2572 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Loa Loa (eye worm) | carboxylesterase | 0.2572 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Echinococcus multilocularis | acetylcholinesterase | 0.2572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0435 | 0.1181 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0435 | 0.1181 | 0.0749 |
Schistosoma mansoni | gliotactin | 0.0435 | 0.1181 | 0.0749 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0435 | 0.1181 | 0.5 |
Onchocerca volvulus | 0.0435 | 0.1181 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2572 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2572 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0435 | 0.1181 | 0.0785 |
Echinococcus granulosus | carboxylesterase 5A | 0.2572 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2572 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2572 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0435 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.0462 | 0.0462 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2572 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0435 | 0.1181 | 0.0749 |
Brugia malayi | hypothetical protein | 0.0435 | 0.1181 | 0.0785 |
Onchocerca volvulus | 0.0435 | 0.1181 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0435 | 0.1181 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Echinococcus granulosus | neuroligin | 0.0435 | 0.1181 | 0.0749 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0435 | 0.1181 | 0.0749 |
Onchocerca volvulus | 0.0435 | 0.1181 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Brugia malayi | Carboxylesterase family protein | 0.2572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Echinococcus multilocularis | neuroligin | 0.0435 | 0.1181 | 0.0749 |
Brugia malayi | Carboxylesterase family protein | 0.0435 | 0.1181 | 0.0785 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0435 | 0.1181 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0435 | 0.1181 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0435 | 0.1181 | 0.0785 |
Onchocerca volvulus | 0.0435 | 0.1181 | 0.5 | |
Onchocerca volvulus | 0.0435 | 0.1181 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0435 | 0.1181 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1181 | 0.1181 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0435 | 0.1181 | 0.0749 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0435 | 0.1181 | 0.0749 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0435 | 0.1181 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0435 | 0.1181 | 0.1181 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0435 | 0.1181 | 0.0749 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.56 nM | Inhibition of human GST-tagged full length B-Raf V600E mutant (unknown origin) using His6-tagged full-length human MEK1 (K97R) substrate and [33P]-gamma-ATP incubated for 120 mins by by filter binding method | ChEMBL. | 25462267 |
IC50 (functional) | = 6.914 uM | Antiproliferative activity against human A375 cells after 72 hrs by CCK8 assay | ChEMBL. | 25462267 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25462267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.