Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | WEE1 G2 checkpoint kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0128 | 1 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0128 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0128 | 1 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0128 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0128 | 1 | 0.5 |
Onchocerca volvulus | 0.0128 | 1 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0128 | 1 | 0.5 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0128 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0128 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0128 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0128 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0128 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 0.5 |
Trypanosoma brucei | wee1-like protein kinase | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0128 | 1 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0069 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0128 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0128 | 1 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0128 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0128 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0128 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0128 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.1 uM | Inhibition of human Weel1 in human NCI-H1299 cells assessed as phosphorylation of Cdk1 after overnight incubation by ELISA PD assay | ChEMBL. | 25589931 |
EC50 (functional) | = 0.69 uM | Cytotoxicity against human NCI-H1299 cells assessed as cell viability after 72 hrs by CellTiterGlo assay | ChEMBL. | 25589931 |
Ki (binding) | = 1.2 nM | Inhibition of GST-tagged human Wee1 | ChEMBL. | 25589931 |
T1/2 (ADMET) | = 2.3 hr | Half life in CD-1 mouse at 3 mg/kg, iv | ChEMBL. | 25589931 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25589931 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.