Detailed information for compound 943329

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.428 | Formula: C24H21NO3
  • H donors: 0 H acceptors: 2 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CCn1c2c3ccccc3C(=O)c2c2c1CCCC2=O
  • InChi: 1S/C24H21NO3/c1-28-20-12-5-2-7-15(20)13-14-25-18-10-6-11-19(26)21(18)22-23(25)16-8-3-4-9-17(16)24(22)27/h2-5,7-9,12H,6,10-11,13-14H2,1H3
  • InChiKey: VCKRZQLIEJEEEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 2, alpha prime polypeptide References
Homo sapiens casein kinase 2, beta polypeptide Starlite/ChEMBL References
Homo sapiens casein kinase 2, alpha 1 polypeptide References
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CMGC/CK2 protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium hominis protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium knowlesi casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium yoelii Protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Giardia lamblia Kinase, CMGC CK2 Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei Casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium vivax casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II, alpha chain (CK II) Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax unspecified product Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium parvum casein kinase II, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania infantum casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii CMGC kinase, CK2 family Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K03097 casein kinase 2, alpha polypeptide, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha prime polypeptide 350 aa 319 aa 50.2 %
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha 1 polypeptide 391 aa 316 aa 51.3 %
Trypanosoma brucei ABC transporter, putative ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 611 aa 557 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum casein kinase II beta chain 0.0044 0.2249 0.2149
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0107 1
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0128 0.002
Entamoeba histolytica casein kinase, putative 0.0162 1 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.0107 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.3843 0.3837
Giardia lamblia Casein kinase II beta chain 0.0013 0.0196 0.0078
Echinococcus granulosus acetylcholinesterase 0.0069 0.3843 0.3776
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Giardia lamblia Casein kinase II beta chain 0.0044 0.2249 0.2156
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.2249 0.2149
Loa Loa (eye worm) carboxylesterase 0.0012 0.0107 0.0098
Plasmodium vivax unspecified product 0.0162 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Echinococcus multilocularis acetylcholinesterase 0.0069 0.3843 0.3776
Loa Loa (eye worm) hypothetical protein 0.0069 0.3843 0.3837
Brugia malayi Carboxylesterase family protein 0.0069 0.3843 0.3837
Echinococcus multilocularis acetylcholinesterase 0.0069 0.3843 0.3776
Echinococcus granulosus carboxylesterase 5A 0.0069 0.3843 0.3776
Brugia malayi Carboxylesterase family protein 0.0012 0.0107 0.0098
Echinococcus granulosus casein kinase ii subunit alpha 0.0162 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Echinococcus multilocularis casein kinase ii subunit alpha 0.0162 1 1
Toxoplasma gondii ck2 beta subunit 0.0044 0.2249 0.2149
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0128 0.002
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0128 0.002
Brugia malayi Carboxylesterase family protein 0.0012 0.0107 0.0098
Giardia lamblia Kinase, CMGC CK2 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.2249 0.2249
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0107 0.0107
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0044 0.2249 0.2149
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Schistosoma mansoni gliotactin 0.0012 0.0107 0.0107
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0013 0.0196 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0162 1 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.2249 0.2149
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0128 1
Trypanosoma brucei Casein kinase II 0.0162 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1
Brugia malayi Carboxylesterase family protein 0.0012 0.0107 0.0098
Loa Loa (eye worm) carboxylesterase 0.0069 0.3843 0.3837
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0128 1
Trypanosoma cruzi casein kinase II, putative 0.0162 1 1
Loa Loa (eye worm) casein kinase II 0.0013 0.0196 0.0187
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.2249 0.2165
Brugia malayi Csnk2b protein 0.0044 0.2249 0.2242
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0107 0.0107
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.2249 0.2149
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.2249 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0098
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0107 1
Entamoeba histolytica protein kinase domain containing protein 0.0162 1 1
Echinococcus granulosus acetylcholinesterase 0.0069 0.3843 0.3776
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0128 0.002
Loa Loa (eye worm) carboxylesterase 0.0012 0.0107 0.0098
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.3843 0.3776
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0107 0.0107
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.2249 0.2149
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0013 0.0196 0.0069
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0013 0.0196 0.0069
Brugia malayi Carboxylesterase family protein 0.0012 0.0107 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1
Brugia malayi hypothetical protein 0.0012 0.0107 0.0098
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Loa Loa (eye worm) Csnk2b protein 0.0044 0.2249 0.2242
Leishmania major casein kinase II, putative 0.0162 1 1
Plasmodium vivax casein kinase II beta chain, putative 0.0044 0.2249 0.2149
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0044 0.2249 0.2149
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Toxoplasma gondii CMGC kinase, CK2 family 0.0162 1 1
Plasmodium falciparum casein kinase II beta chain 0.0044 0.2249 0.2149
Plasmodium vivax casein kinase II beta chain, putative 0.0044 0.2249 0.2149
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.2249 0.2149
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.2249 0.2165
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0128 1
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0162 1 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.2249 0.2149
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0128 0.0128
Brugia malayi Carboxylesterase family protein 0.0069 0.3843 0.3837
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0128 0.002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.3843 0.3843
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0128 0.002
Schistosoma mansoni ABC transporter 0.001 0.0009 0.0009
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Loa Loa (eye worm) hypothetical protein 0.0069 0.3843 0.3837
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Schistosoma mansoni acetylcholinesterase 0.0012 0.0107 0.0107
Brugia malayi casein kinase II, putaitve 0.0013 0.0196 0.0187
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.2249 0.2165
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0013 0.0196 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0013 0.0196 0.0089
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.2249 1
Schistosoma mansoni protein kinase 0.0162 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0162 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.21 uM Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux after 30 mins by FACS method ChEMBL. 25272055
IC50 (binding) = 1.4 uM Inhibition of human recombinant CK2a1/CK2b holoenzyme expressed in Escherichia coli BL21(DE3) pre-incubated for 10 mins before substrate addition by capillary electrophoresis based assay ChEMBL. 25272055
IG50 (ADMET) = 27.2 uM Intrinsic cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay ChEMBL. 25272055
Inhibition (binding) = 87 % Inhibition of human recombinant CK2a1/CK2b holoenzyme expressed in Escherichia coli BL21(DE3) at 10 uM pre-incubated for 10 mins before substrate addition by capillary electrophoresis based assay ChEMBL. 25272055
Inhibition (binding) = 106 % Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux at 10 uM after 30 mins by FACS method ChEMBL. 25272055

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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