Detailed information for compound 943446

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.811 | Formula: C17H18ClN5
  • H donors: 1 H acceptors: 2 LogP: 2.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H]1CCCN(C1)c1ccn2c(n1)c(cn2)c1cccc(c1)Cl
  • InChi: 1S/C17H18ClN5/c18-13-4-1-3-12(9-13)15-10-20-23-8-6-16(21-17(15)23)22-7-2-5-14(19)11-22/h1,3-4,6,8-10,14H,2,5,7,11,19H2/t14-/m0/s1
  • InChiKey: KYMUXYIOLJRDOL-AWEZNQCLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein lipid droplet kinase (LDK) Pim-2 proto-oncogene, serine/threonine kinase 311 aa 278 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0291 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0029 0.0412
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0171 0.0636
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.001 0.0038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.1091
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0291 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0289 0.1083
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0066 0.0291 0.6255
Plasmodium vivax glutathione reductase, putative 0.01 0.0459 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0029 0.0412
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0165 0.3442
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0162
Loa Loa (eye worm) nuclear factor I 0.0009 0.0012 0.0034
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0541 0.2648 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0063 0.0238
Trypanosoma brucei DNA polymerase eta, putative 0.0069 0.0307 0.6608
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0024
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.005 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0149 0.0562
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0029 0.0412
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0171 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0053
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0066 0.0291 0.1244
Brugia malayi MH2 domain containing protein 0.0017 0.005 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0056
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0202 0.683
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0033
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0056
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0033
Schistosoma mansoni smad1 5 8 and 0.0017 0.005 0.0187
Trypanosoma brucei unspecified product 0.0029 0.0107 0.2153
Echinococcus multilocularis dna polymerase eta 0.0069 0.0307 0.1159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0162
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0136 0.2803
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0056
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Schistosoma mansoni hypothetical protein 0.0411 0.2 0.7553
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0066 0.0291 0.6255
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2024 1 1
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0053
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Echinococcus multilocularis glutamate synthase 0.0009 0.001 0.0038
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.005 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0053
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0013 0.0049
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0063 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0029 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0029 0.0412
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.1182
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0541 0.2648 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0107 0.2153
Loa Loa (eye worm) hypothetical protein 0.0069 0.0307 0.1151
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.0922 0.348
Schistosoma mansoni Smad4 0.0008 0.0003 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0136 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0056
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.1094 0.1513
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0202 0.683
Plasmodium falciparum glutathione reductase 0.0035 0.0136 0.2803
Mycobacterium tuberculosis Probable reductase 0.0228 0.1094 0.1513
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0107 0.2153
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0063 0.1182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0046
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.001 0.0038
Echinococcus granulosus smad 0.0017 0.005 0.0187
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0525
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0107 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0053
Treponema pallidum NADH oxidase 0.0035 0.0136 0.0126
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Echinococcus granulosus dna polymerase eta 0.0069 0.0307 0.1159
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0053
Trichomonas vaginalis MYB3r3, putative 0.0048 0.0202 0.683
Schistosoma mansoni DNA helicase recq1 0.002 0.0063 0.0238
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0459 0.1735
Brugia malayi MH1 domain containing protein 0.0009 0.0012 0.0039
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0003 0.001
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0289 0.1091
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0056
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0291 0.6255
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0291 0.6255
Loa Loa (eye worm) hypothetical protein 0.0541 0.2648 1
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0038
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0475 0.2321 0.8765
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0029 0.0412
Brugia malayi CXXC zinc finger family protein 0.0029 0.0107 0.0452
Leishmania major DNA polymerase kappa, putative 0.0013 0.0029 0.0412
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.0307 0.1313
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0048 0.0203 0.0694
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.1094 0.1513
Echinococcus multilocularis smad 0.0017 0.005 0.0187
Schistosoma mansoni smad 0.0008 0.0003 0.001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0541 0.2648 1
Plasmodium falciparum thioredoxin reductase 0.0035 0.0136 0.2803
Trypanosoma brucei unspecified product 0.0029 0.0107 0.2153
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Echinococcus multilocularis Smad4 0.0017 0.005 0.0187
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0171 0.5721
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0136 0.2803
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0202 0.683
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0056
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.009 0.0379
Echinococcus granulosus glutamate synthase 0.0009 0.001 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0056
Brugia malayi Thioredoxin reductase 0.01 0.0459 0.197
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0136 0.0126
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0066 0.0291 0.1099
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0063 0.0201
Brugia malayi MH1 domain containing protein 0.0009 0.0012 0.0039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0066 0.0291 0.6255
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0066 0.0291 0.1244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0235 0.0809
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0171
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0056
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.7226
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0184
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0029 0.0067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0136 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Giardia lamblia Myb 1-like protein 0.0048 0.0203 0.0732
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0289 0.1083
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0291 0.1099
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0171 0.3578
Plasmodium falciparum thioredoxin reductase 0.01 0.0459 1
Brugia malayi Protein kinase domain containing protein 0.0193 0.0922 0.3963
Schistosoma mansoni DNA helicase recq5 0.002 0.0063 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0066 0.0291 0.1099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Giardia lamblia DNA damage repair protein 0.0013 0.0029 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0053
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0291 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0136 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0229
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0136 0.0453
Schistosoma mansoni Smad4 0.0017 0.005 0.0187
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0289 0.1235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0291 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0193 0.0922 0.348
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0171 0.0645
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0136 0.0453
Echinococcus granulosus geminin 0.0358 0.1738 0.6564
Loa Loa (eye worm) RNA binding protein 0.0065 0.0289 0.1083
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.005 0.0178
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.001 0.0032
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Leishmania major cAMP-specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.001 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.001 0.0038
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0165 0.0556
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0193 0.0922 0.348
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0171 0.3578
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0098
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0571 0.2794 0.2786
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.1091
Leishmania major DNA damage repair protein, putative 0.0013 0.0029 0.0412
Giardia lamblia DINP protein human, muc B family 0.0042 0.0171 0.061
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0171
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0053
Echinococcus granulosus bloom syndrome protein 0.002 0.0063 0.0238
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0541 0.2648 0.9477
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0202 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0029 0.0412
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0015 0.0133
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.122 0.1689
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0066 0.0291 0.1099
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.7226
Loa Loa (eye worm) Smad1 0.0017 0.005 0.0178
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0066 0.0291 0.6255
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2024 1 1
Trichomonas vaginalis C-MYB, putative 0.0048 0.0202 0.683
Schistosoma mansoni sulfide quinone reductase 0.0009 0.001 0.0038
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0136 0.2803
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0516
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0202 0.683
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0149 0.0562
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0291 0.6255
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0136 0.0126
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0202 1
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.7226
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.001 0.0038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0066 0.0291 0.6255
Onchocerca volvulus 0.001 0.0015 0.0133
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.1214 0.458
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0171 0.0726
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.022 0.0821
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.005 0.0178
Echinococcus granulosus dna polymerase kappa 0.0042 0.0171 0.0645
Schistosoma mansoni hypothetical protein 0.0358 0.1738 0.6564
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0015 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0056
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0291 0.6255
Loa Loa (eye worm) hypothetical protein 0.0066 0.0291 0.1091
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0307 0.6608
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.005 0.0187
Loa Loa (eye worm) RecQ helicase 0.002 0.0063 0.0229
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0066 0.0291 0.1099
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0015 0.0106
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Trypanosoma brucei trypanothione reductase 0.01 0.0459 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0291 0.1099
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0171 0.0161
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0066 0.0291 0.1099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0171
Brugia malayi RNA binding protein 0.0065 0.0289 0.1235
Schistosoma mansoni hypothetical protein 0.0009 0.001 0.0038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Brugia malayi MH1 domain containing protein 0.0017 0.005 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0291 0.6255
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2024 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0136 0.0514
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0056
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0015 0.0106
Schistosoma mansoni smad1 5 8 and 0.0017 0.005 0.0187
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.001 0.0038
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Leishmania major DNA polymerase eta, putative 0.004 0.0165 0.3442
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0066 0.0291 0.6255
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0541 0.2648 1
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0459 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0571 0.2794 1
Leishmania major DNA polymerase eta, putative 0.0069 0.0307 0.6608
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus granulosus dnaJ subfamily B 0.0411 0.2 0.7553
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0541 0.2648 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0013 0.0063
Plasmodium vivax phosphodiesterase gamma, putative 0.0066 0.0291 0.6255
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0029 0.0108
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0029 0.0412
Trypanosoma brucei unspecified product 0.0042 0.0171 0.3578
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0063 0.1889
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0261
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.001 0.0038
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0136 0.2803
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0056
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.001 0.0038
Brugia malayi polk-prov protein 0.0013 0.0029 0.0112
Loa Loa (eye worm) glutathione reductase 0.01 0.0459 0.1727
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0029 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0171 0.3578
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.0922 0.3474
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0063 0.1889
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.022 0.0937
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0193 0.0922 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0291 0.1099
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Trichomonas vaginalis pc-MYB2, putative 0.0048 0.0202 0.683
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0202 0.683
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0291 0.6255
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0136 0.2803
Giardia lamblia Hypothetical protein 0.0066 0.0291 0.1066
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.001 0.0038
Schistosoma mansoni cpg binding protein 0.003 0.0116 0.0436
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0571 0.2794 0.2786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0015 0.0133
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0136 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0136 0.0126
Giardia lamblia hypothetical protein 0.0066 0.0291 0.1066
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0171 0.0645
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0171 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.1091
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.2 0.7553
Trichomonas vaginalis C-MYB, putative 0.0048 0.0202 0.683
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0136 0.2803
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.1094 0.1513
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Schistosoma mansoni hypothetical protein 0.0037 0.0149 0.0562
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0003 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0053
Loa Loa (eye worm) hypothetical protein 0.0066 0.0291 0.1091
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0171
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0541 0.2648 1
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0459 0.1727
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0268 0.1011
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.1182
Entamoeba histolytica recQ family DNA helicase 0.001 0.0015 0.0247
Trichomonas vaginalis MYB72, putative 0.0048 0.0202 0.683
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0136 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0291 0.6255
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0291 1
Loa Loa (eye worm) programmed cell death 8 0.0009 0.001 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.0291 0.6255
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0171
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0171 0.0161
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.001 0.0038
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0136 0.0176
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trichomonas vaginalis MYB, putative 0.0048 0.0203 0.6871
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0203 0.6871
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0193 0.0922 0.3474
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0171
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0136 0.0514
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0136 0.0126
Brugia malayi hypothetical protein 0.0037 0.0149 0.0631
Trichomonas vaginalis pc-MYB2, putative 0.0048 0.0202 0.683
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0029 0.0412
Loa Loa (eye worm) PDE1B protein 0.0066 0.0291 0.1091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0291 0.1091
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0203 0.6871
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0063 0.0238
Echinococcus multilocularis bloom syndrome protein 0.002 0.0063 0.0238
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0136 0.2803
Leishmania major trypanothione reductase 0.01 0.0459 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0291 0.1099
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0056
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.1094 0.1513
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0066 0.0291 0.6255
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1453 0.7171 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0289 0.1091
Brugia malayi Smad1 0.0017 0.005 0.0203
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0034
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0136 0.0514
Plasmodium falciparum glutathione reductase 0.01 0.0459 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0063 0.1182
Entamoeba histolytica hypothetical protein 0.0037 0.0149 0.7226
Schistosoma mansoni Smad4 0.0008 0.0003 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0028
Schistosoma mansoni sulfide quinone reductase 0.0009 0.001 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0171 0.0645
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Toxoplasma gondii thioredoxin reductase 0.01 0.0459 0.1615
Brugia malayi TAR-binding protein 0.0065 0.0289 0.1235
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0038
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.001 0.0038
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.009 0.0379
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0029 0.0067
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0291 0.1244
Schistosoma mansoni hypothetical protein 0.0358 0.1738 0.6564
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.001 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0107 0.2153
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0291 0.6255
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0291 0.1244
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.122 0.1689
Schistosoma mansoni cpg binding protein 0.003 0.0116 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0053
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Leishmania major DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0063 0.0238
Entamoeba histolytica recQ family helicase, putative 0.001 0.0013 0.0147
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0066 0.0291 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0015 0.0133
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0066 0.0291 0.1244
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0066 0.0291 0.1099
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0136 0.0576
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0056
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0171 0.5721
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0029 0.0412
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0063 0.1889
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.1094 0.1513
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0202 1
Brugia malayi MH2 domain containing protein 0.0252 0.1214 0.5225
Entamoeba histolytica recQ family helicase, putative 0.002 0.0063 0.2766
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0053
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1453 0.7171 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.122 0.1689
Brugia malayi MH1 domain containing protein 0.0017 0.005 0.0203
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0193 0.0922 0.3963
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0063 0.1182
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0459 1
Echinococcus multilocularis cpg binding protein 0.003 0.0116 0.0436
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0056
Onchocerca volvulus 0.0029 0.0107 0.1141
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0171 0.0645
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0171
Brugia malayi glutathione reductase 0.01 0.0459 0.197
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0571 0.2794 0.3887
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0202 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0056
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.005 0.0187
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0136 0.2803
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0015 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0046
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0056
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0459 0.1735
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.001 0.0038
Onchocerca volvulus 0.0009 0.001 0.0081
Echinococcus granulosus Smad4 0.0017 0.005 0.0187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0056
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0475 0.2321 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Schistosoma mansoni smad 0.0017 0.005 0.0187
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0003 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0056
Brugia malayi glutamate synthase 0.0009 0.001 0.0032
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0048 0.0202 0.683
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0063 0.0261
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0291 0.6255
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.1091
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.001 0.0028
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0291 0.1099
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.001 0.0032
Leishmania major hypothetical protein, conserved 0.0066 0.0291 0.6255
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0475 0.2321 0.8766
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.005 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0171
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0053
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0063 0.0261
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.001 0.0032
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0475 0.2321 0.8766
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0053
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0066 0.0291 0.1091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0291 0.101
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0015 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0136 0.4482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0046
Leishmania major hypothetical protein, conserved 0.0066 0.0291 0.6255
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0056
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0459 0.0628
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0149 0.0562
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0171 0.3578
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0046
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0136 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0291 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0171 0.0225
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0003 0.001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0291 0.1099
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0139 0.0589
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.122 0.1689
Echinococcus granulosus cpg binding protein 0.003 0.0116 0.0436
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0048 0.0202 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.0291 0.1099
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.1214 0.458
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.1094 0.1513
Schistosoma mansoni cpg binding protein 0.0029 0.0107 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0066 0.0291 0.1099
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0136 0.2803
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0029 0.0412
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0056
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0066 0.0291 0.1099
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0063 0.0238
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Schistosoma mansoni DNA polymerase eta 0.0069 0.0307 0.1159
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0291 0.6255
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0291 0.6255
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0136 0.4482
Schistosoma mansoni smad1 5 8 and 0.0017 0.005 0.0187
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0136 0.2803
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0291 0.1244
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.022 0.0821
Brugia malayi MH2 domain containing protein 0.0017 0.005 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0029 0.0412
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.022 0.0937
Echinococcus multilocularis geminin 0.0358 0.1738 0.6564
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0171 0.8375
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0136 0.0126
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0291 0.6255
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0291 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.3578
Mycobacterium ulcerans hypothetical protein 0.0013 0.0029 0.0019
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0015 0.0106

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 94 nM Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay ChEMBL. 25589932
IC50 (binding) = 94 nM Kinase-Glo Assay BINDINGDB. No reference
IC50 (binding) = 2005 nM Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay ChEMBL. 25589932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.