Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitotic cyclin 6 | 0.0198 | 0.2388 | 0.2172 |
Mycobacterium ulcerans | proteasome PrcB | 0.0552 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Trichomonas vaginalis | cyclins, putative | 0.0147 | 0.1287 | 0.1287 |
Echinococcus granulosus | cyclin b3 | 0.0147 | 0.1287 | 0.104 |
Echinococcus granulosus | cyclins | 0.0147 | 0.1287 | 0.104 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0099 | 0.0275 | 0.0275 |
Trichomonas vaginalis | cyclins, putative | 0.0198 | 0.2388 | 0.2388 |
Giardia lamblia | Cyclin A | 0.0147 | 0.1287 | 0.104 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0552 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0552 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0552 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0552 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0552 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0198 | 0.2388 | 0.2172 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0376 | 0.622 | 0.6113 |
Echinococcus granulosus | cyclins | 0.0147 | 0.1287 | 0.104 |
Trichomonas vaginalis | cyclins, putative | 0.0198 | 0.2388 | 0.2388 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0198 | 0.2388 | 0.2172 |
Entamoeba histolytica | cyclin, putative | 0.0147 | 0.1287 | 0.104 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0198 | 0.2388 | 0.2172 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0376 | 0.622 | 0.6113 |
Schistosoma mansoni | cyclin B | 0.0198 | 0.2388 | 0.2382 |
Trichomonas vaginalis | cyclins, putative | 0.0198 | 0.2388 | 0.2388 |
Trichomonas vaginalis | cyclin D, putative | 0.0147 | 0.1287 | 0.1287 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0552 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0147 | 0.1287 | 0.1287 |
Echinococcus granulosus | cyclins | 0.0147 | 0.1287 | 0.104 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0552 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0147 | 0.1287 | 0.104 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0376 | 0.622 | 0.6113 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0376 | 0.622 | 0.6113 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0198 | 0.2388 | 0.2172 |
Trichomonas vaginalis | cyclin B, putative | 0.0198 | 0.2388 | 0.2388 |
Leishmania major | cyclin | 0.0198 | 0.2388 | 0.2172 |
Entamoeba histolytica | cyclin family protein | 0.0147 | 0.1287 | 0.104 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0552 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0552 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0198 | 0.2388 | 0.2388 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0552 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2388 | 0.2172 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0552 | 1 | 0.5 |
Schistosoma mansoni | cyclins | 0.0147 | 0.1287 | 0.1281 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0099 | 0.0275 | 0.0268 |
Echinococcus granulosus | cyclins | 0.0147 | 0.1287 | 0.104 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0552 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0552 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0198 | 0.2388 | 0.2172 |
Echinococcus granulosus | cyclin B3 1 | 0.0147 | 0.1287 | 0.104 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Echinococcus granulosus | cyclin B | 0.0198 | 0.2388 | 0.2172 |
Echinococcus multilocularis | cyclin b3 | 0.0147 | 0.1287 | 0.104 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Trypanosoma cruzi | cyclin 6, putative | 0.0198 | 0.2388 | 0.2172 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0552 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0147 | 0.1287 | 0.104 |
Trichomonas vaginalis | cyclins, putative | 0.0198 | 0.2388 | 0.2388 |
Echinococcus multilocularis | cyclin B3 1 | 0.0147 | 0.1287 | 0.104 |
Trichomonas vaginalis | cyclin A, putative | 0.0198 | 0.2388 | 0.2388 |
Trichomonas vaginalis | cyclin B, putative | 0.0198 | 0.2388 | 0.2388 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0552 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.0147 | 0.1287 | 0.104 |
Trypanosoma cruzi | cyclin, putative | 0.0198 | 0.2388 | 0.2172 |
Plasmodium falciparum | cyclin | 0.0147 | 0.1287 | 0.104 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0198 | 0.2388 | 0.2172 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2388 | 0.2172 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Trichomonas vaginalis | cyclin B3, putative | 0.0147 | 0.1287 | 0.1287 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0552 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0147 | 0.1287 | 0.1287 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0198 | 0.2388 | 0.2172 |
Onchocerca volvulus | 0.0198 | 0.2388 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0147 | 0.1287 | 0.1287 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Echinococcus multilocularis | cyclin B | 0.0198 | 0.2388 | 0.2172 |
Schistosoma mansoni | cyclin B3 | 0.0376 | 0.622 | 0.6217 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Echinococcus multilocularis | cyclins | 0.0147 | 0.1287 | 0.104 |
Toxoplasma gondii | hypothetical protein | 0.0111 | 0.0528 | 0.0259 |
Trichomonas vaginalis | cyclin B, putative | 0.0198 | 0.2388 | 0.2388 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 51 uM | Inhibition of human CYP2A6 in baculovirus-infected insect cell system using coumarin 7 as substrate preincubated for 10 mins by fluorescence assay | ChEMBL. | 25458499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.