Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0491 | 0.1603 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2905 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.003 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2905 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0491 | 0.1603 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0491 | 0.1603 | 0.1603 |
Echinococcus granulosus | neuroligin | 0.0491 | 0.1603 | 0.1603 |
Toxoplasma gondii | beta-tubulin, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2905 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0491 | 0.1603 | 1 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0491 | 0.1603 | 0.5 | |
Plasmodium falciparum | tubulin beta chain | 0.003 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2905 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0491 | 0.1603 | 0.1603 |
Echinococcus granulosus | carboxylesterase 5A | 0.2905 | 1 | 1 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0491 | 0.1603 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0491 | 0.1603 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0491 | 0.1603 | 0.1603 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0491 | 0.1603 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0491 | 0.1603 | 1 |
Echinococcus multilocularis | neuroligin | 0.0491 | 0.1603 | 0.1603 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Brugia malayi | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Plasmodium vivax | tubulin beta chain, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0491 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Onchocerca volvulus | 0.0491 | 0.1603 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Entamoeba histolytica | tubulin family protein | 0.003 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2905 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2905 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2905 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2905 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2905 | 1 | 1 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2905 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0491 | 0.1603 | 0.1603 |
Toxoplasma gondii | beta tubulin | 0.003 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.003 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Trypanosoma brucei | beta tubulin | 0.003 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0491 | 0.1603 | 0.1603 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0491 | 0.1603 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0491 | 0.1603 | 0.1603 |
Onchocerca volvulus | 0.0491 | 0.1603 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.1603 | 0.1603 |
Echinococcus multilocularis | acetylcholinesterase | 0.2905 | 1 | 1 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0491 | 0.1603 | 0.1603 |
Schistosoma mansoni | gliotactin | 0.0491 | 0.1603 | 0.1603 |
Trypanosoma brucei | beta tubulin | 0.003 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.08 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 25462279 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25462279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.