Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Glycine max | Lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0328 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0328 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0328 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0328 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0328 | 0.5 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0328 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0328 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0328 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0328 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0328 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0328 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0328 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0328 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0328 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0 uM | Inhibition of soybean LOX assessed as reduction in conversion of sodium linoleate to 13-hydroperoxylinoleic acid by UV spectroscopy | ChEMBL. | 25456384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.