Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4263 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4263 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4263 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4263 | 1 |
Brugia malayi | RNA binding protein | 0.0064 | 0.4263 | 0.4263 |
Onchocerca volvulus | Huntingtin homolog | 0.0124 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.1001 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.4263 | 0.4263 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4263 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.4263 | 0.4263 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.4263 | 0.4263 |
Onchocerca volvulus | Huntingtin homolog | 0.0124 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.1001 | 0.1001 |
Leishmania major | cytochrome p450-like protein | 0.002 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.4263 | 0.4263 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4263 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2556 | 0.2556 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2556 | 0.2556 |
Trypanosoma cruzi | cytochrome P450, putative | 0.002 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 20 nM | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method | ChEMBL. | 25455488 |
Efficacy (binding) | = 74 % | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method relative to AR231453 | ChEMBL. | 25455488 |
Ratio (binding) | = 0.06 | Agonist activity at GPR119 in mouse enteroendocrine cells assessed as GLP1 secretion by luciferase reporter gene assay relative to AR231453 | ChEMBL. | 25455488 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.