Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell adhesion molecule | 0.0011 | 0.0016 | 0.0016 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.0286 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0058 | 0.1453 | 0.5461 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0058 | 0.1453 | 0.1201 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0058 | 0.1453 | 0.1453 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0334 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.002 | 0.0286 | 0.0286 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0334 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0097 | 0.266 | 0.266 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0016 | 0.0016 |
Echinococcus granulosus | hypothetical protein | 0.0334 | 1 | 1 |
Mycobacterium leprae | Possible oxidoreductase | 0.0097 | 0.266 | 0.2444 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.002 | 0.0286 | 0.0286 |
Plasmodium falciparum | thioredoxin reductase | 0.002 | 0.0286 | 0.1074 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0097 | 0.266 | 0.2444 |
Trypanosoma cruzi | aldo-keto reductase | 0.0334 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0097 | 0.266 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0334 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0097 | 0.266 | 0.266 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0013 | 0.0084 | 0.0084 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0097 | 0.266 | 0.266 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0334 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0237 | 0.7007 | 0.7007 |
Entamoeba histolytica | aldose reductase, putative | 0.0334 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0058 | 0.1453 | 0.5461 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0334 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0011 | 0.0016 | 0.0016 |
Toxoplasma gondii | aldose reductase, putative | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.002 | 0.0286 | 0.0286 |
Trypanosoma brucei | prostaglandin f synthase | 0.0334 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0097 | 0.266 | 0.266 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.0334 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0334 | 1 | 1 |
Onchocerca volvulus | 0.0334 | 1 | 1 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0058 | 0.1453 | 0.1453 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0334 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0058 | 0.1453 | 0.1201 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0058 | 0.1453 | 0.1201 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0058 | 0.1453 | 0.1201 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0334 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0334 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0013 | 0.0084 | 0.0084 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0097 | 0.266 | 0.266 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0097 | 0.266 | 0.266 |
Entamoeba histolytica | aldose reductase, putative | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0037 | 0.0037 |
Leishmania major | aldo-keto reductase-like protein | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0334 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0334 | 1 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.002 | 0.0286 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0084 | 0.0084 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0334 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.002 | 0.0286 | 0.0286 |
Echinococcus multilocularis | aldehyde reductase | 0.0237 | 0.7007 | 0.7007 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.018 | 0.018 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0011 | 0.0016 | 0.0016 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0097 | 0.266 | 0.266 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0058 | 0.1453 | 0.1453 |
Plasmodium falciparum | thioredoxin reductase | 0.0058 | 0.1453 | 0.5461 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0097 | 0.266 | 0.266 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0097 | 0.266 | 0.266 |
Onchocerca volvulus | 0.0097 | 0.266 | 0.266 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0097 | 0.266 | 0.2444 |
Mycobacterium tuberculosis | Conserved protein | 0.0097 | 0.266 | 0.2444 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | oxidoreductase | 0.0334 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0058 | 0.1453 | 0.5461 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.002 | 0.0286 | 0.1074 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0097 | 0.266 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.002 | 0.0286 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0058 | 0.1453 | 0.1453 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0097 | 0.266 | 0.2444 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.0286 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0017 | 0.018 | 0.018 |
Loa Loa (eye worm) | oxidoreductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0097 | 0.266 | 0.2444 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0097 | 0.266 | 0.2444 |
Brugia malayi | glutathione reductase | 0.0058 | 0.1453 | 0.1453 |
Mycobacterium ulcerans | hypothetical protein | 0.0097 | 0.266 | 0.2444 |
Echinococcus granulosus | aldo keto reductase | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0334 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.002 | 0.0286 | 0.1074 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0097 | 0.266 | 0.2444 |
Treponema pallidum | NADH oxidase | 0.002 | 0.0286 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0058 | 0.1453 | 0.1453 |
Plasmodium falciparum | glutathione reductase | 0.002 | 0.0286 | 0.1074 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0334 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.002 | 0.0286 | 0.0286 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0015 | 0.0121 | 0.0121 |
Echinococcus multilocularis | aldo keto reductase | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0334 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0015 | 0.0121 | 0.0121 |
Echinococcus granulosus | aldo keto reductase | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0058 | 0.1453 | 0.1453 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0097 | 0.266 | 0.2444 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0237 | 0.7007 | 0.6919 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0097 | 0.266 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0097 | 0.266 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.002 | 0.0286 | 0.1074 |
Onchocerca volvulus | 0.0334 | 1 | 1 | |
Onchocerca volvulus | 0.0334 | 1 | 1 | |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.002 | 0.0286 | 0.0286 |
Schistosoma mansoni | aldo-keto reductase | 0.0334 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0334 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0334 | 1 | 1 |
Onchocerca volvulus | 0.0334 | 1 | 1 | |
Onchocerca volvulus | 0.0334 | 1 | 1 | |
Toxoplasma gondii | aldo-keto reductase | 0.0097 | 0.266 | 0.266 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0097 | 0.266 | 0.2444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.