Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c4b binding protein beta chain | 0.0011 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.1979 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.002 | 0.1979 | 0.1966 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.002 | 0.1979 | 0.1966 |
Leishmania major | trypanothione reductase | 0.0057 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0013 | 0.0591 | 0.0591 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Plasmodium falciparum | glutathione reductase | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Toxoplasma gondii | thioredoxin reductase | 0.0057 | 1 | 1 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0011 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1256 | 0.1242 |
Trichomonas vaginalis | mercuric reductase, putative | 0.002 | 0.1979 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0057 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0015 | 0.085 | 0.0836 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.002 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0128 | 0.0112 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0011 | 0.0128 | 0.0128 |
Plasmodium falciparum | thioredoxin reductase | 0.002 | 0.1979 | 0.1966 |
Trichomonas vaginalis | glutathione reductase, putative | 0.002 | 0.1979 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.002 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0011 | 0.0128 | 0.0112 |
Treponema pallidum | NADH oxidase | 0.002 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0057 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0015 | 0.085 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0591 | 0.0575 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0057 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.002 | 0.1979 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.002 | 0.1979 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.002 | 0.1979 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0011 | 0.0016 | 0.0016 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0011 | 0.0128 | 0.0128 |
Echinococcus multilocularis | roundabout 2 | 0.0013 | 0.0591 | 0.0591 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0011 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0057 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.1979 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.1979 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.002 | 0.1979 | 0.1966 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0011 | 0.0016 | 0.0016 |
Plasmodium falciparum | thioredoxin reductase | 0.0057 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.002 | 0.1979 | 0.1966 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.002 | 0.1979 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0057 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.002 | 0.1979 | 0.1966 |
Plasmodium falciparum | glutathione reductase | 0.002 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0591 | 0.0575 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0257 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.1979 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | glutathione reductase | 0.0057 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0057 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0057 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0016 | 0.1256 | 0.1242 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0128 | 0.0112 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.002 | 0.1979 | 0.1966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.