Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0011 | 0.0128 | 0.0112 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0011 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.002 | 0.1979 | 0.1966 |
Plasmodium vivax | glutathione reductase, putative | 0.0057 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0057 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0057 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.002 | 0.1979 | 0.1966 |
Plasmodium falciparum | thioredoxin reductase | 0.002 | 0.1979 | 0.1966 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.002 | 0.1979 | 0.1966 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0057 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0016 | 0.1256 | 0.1242 |
Trichomonas vaginalis | glutathione reductase, putative | 0.002 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0273 | 0.0257 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.002 | 0.1979 | 0.1966 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0011 | 0.0128 | 0.0128 |
Trichomonas vaginalis | mercuric reductase, putative | 0.002 | 0.1979 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.1979 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0011 | 0.0016 | 0.0016 |
Plasmodium falciparum | glutathione reductase | 0.002 | 0.1979 | 0.1966 |
Plasmodium falciparum | thioredoxin reductase | 0.0057 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0057 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.1979 |
Echinococcus multilocularis | roundabout 2 | 0.0013 | 0.0591 | 0.0591 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.002 | 0.1979 | 0.1966 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0128 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0591 | 0.0575 |
Treponema pallidum | NADH oxidase | 0.002 | 0.1979 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0057 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0057 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.002 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1256 | 0.1242 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | glutathione reductase | 0.0057 | 1 | 1 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0011 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0591 | 0.0575 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Brugia malayi | Thioredoxin reductase | 0.0057 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0015 | 0.085 | 0.0836 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.002 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Echinococcus granulosus | roundabout 2 | 0.0013 | 0.0591 | 0.0591 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.002 | 0.1979 | 0.1966 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.1979 | 0.5 |
Leishmania major | trypanothione reductase | 0.0057 | 1 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0011 | 0.0016 | 0.0016 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.002 | 0.1979 | 0.5 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0015 | 0.085 | 0.0836 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.002 | 0.1979 | 0.1979 |
Schistosoma mansoni | cell adhesion molecule | 0.0011 | 0.0128 | 0.0128 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.002 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0128 | 0.0112 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.002 | 0.1979 | 0.5 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0011 | 0.0016 | 0.0016 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.002 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0.0016 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.002 | 0.1979 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 45.7 % | Inhibition of LPS-induced TNFalpha production in mouse RAW264.7 cells 10 uM | ChEMBL. | 25467157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.