Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0041 | 0.0039 | 0.0039 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0122 | 0.0312 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0062 | 0.0108 | 0.0108 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0062 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0459 | 0.1447 | 0.9977 | |
Echinococcus multilocularis | protein patched | 0.1233 | 0.4058 | 0.4043 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0041 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0127 | 0.0127 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0041 | 0.0039 | 0.0039 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2995 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1233 | 0.4058 | 0.4043 |
Onchocerca volvulus | 0.0061 | 0.0104 | 0.0458 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0104 | 0.0104 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2995 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1429 | 0.4718 | 0.4718 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0212 | 0.0212 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0062 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | carboxylesterase | 0.0068 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1233 | 0.4058 | 0.4058 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0312 | 0.0312 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0122 | 0.0312 | 0.0287 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0062 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.1429 | 0.4718 | 0.4718 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0068 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0212 | 0.0212 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.0127 | 0.0102 |
Echinococcus granulosus | carboxylesterase 5A | 0.0068 | 0.0127 | 0.0102 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1405 | 0.4638 | 1 |
Brugia malayi | CHE-14 protein | 0.1233 | 0.4058 | 0.4058 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0212 | 0.0212 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0212 | 0.0212 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0007 | 0.0007 |
Brugia malayi | Peptidase family M13 containing protein | 0.0122 | 0.0312 | 0.0312 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2995 | 1 | 1 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.046 | 0.145 | 0.1429 |
Echinococcus granulosus | lysosomal protective protein | 0.0041 | 0.0039 | 0.0014 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.0127 | 0.0102 |
Onchocerca volvulus | 0.046 | 0.145 | 1 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1405 | 0.4638 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0039 | 0.0039 |
Schistosoma mansoni | neprilysin | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.2995 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0204 | 0.0204 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2995 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2995 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.0127 | 0.0102 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0122 | 0.0312 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0212 | 0.0212 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1233 | 0.4058 | 0.4043 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1405 | 0.4638 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2995 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0312 | 0.0312 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0122 | 0.0312 | 0.0312 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.0127 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0007 | 0.0007 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1405 | 0.4638 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0122 | 0.0312 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1233 | 0.4058 | 0.4043 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0122 | 0.0312 | 0.0287 |
Schistosoma mansoni | serine/threonine protein kinase | 0.046 | 0.145 | 0.145 |
Schistosoma mansoni | patched 1 | 0.1233 | 0.4058 | 0.4058 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0068 | 0.0127 | 0.0127 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1233 | 0.4058 | 0.4043 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.009 | 0.0204 | 0.0204 |
Echinococcus multilocularis | lysosomal protective protein | 0.0041 | 0.0039 | 0.0014 |
Echinococcus multilocularis | protein dispatched 1 | 0.1233 | 0.4058 | 0.4043 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 0.4058 | 0.4058 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0068 | 0.0127 | 0.0102 |
Echinococcus multilocularis | rho associated protein kinase | 0.046 | 0.145 | 0.1429 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2995 | 1 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0062 | 0.0108 | 0.0108 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.0127 | 0.0127 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1233 | 0.4058 | 0.4058 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0204 | 0.0204 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1233 | 0.4058 | 0.4043 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0007 | 0.0007 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2995 | 1 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0122 | 0.0312 | 0.0312 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0032 | 0.0007 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 14.4 % | Displacement of [3H]TCP from rat brain NMDA receptor at 1 uM | ChEMBL. | 25499436 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.