Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.538 | 0.4897 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1511 | 0.2652 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0058 | 0.2169 | 0.3902 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0112 | 0.538 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0075 | 0.3191 | 0.3011 |
Trypanosoma cruzi | cysteine protease, putative | 0.0058 | 0.2169 | 0.135 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0921 | 0.153 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.538 | 0.5258 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.019 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.019 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1511 | 0.1287 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0112 | 0.538 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0037 | 0.0947 | 0.0708 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.538 | 0.5258 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3191 | 0.5931 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0058 | 0.2169 | 0.135 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1325 | 0.2462 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0112 | 0.538 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.019 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0112 | 0.538 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0947 | 0.1761 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Plasmodium vivax | vivapain-2 | 0.0112 | 0.538 | 0.4897 |
Entamoeba histolytica | cysteine protease, putative | 0.0112 | 0.538 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1511 | 0.1511 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0074 | 0.3148 | 0.2967 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.019 | 1 | 1 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1511 | 0.1511 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1511 | 0.1511 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0112 | 0.538 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0058 | 0.2169 | 0.2169 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.538 | 0.5258 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.3272 | 0.3094 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0112 | 0.538 | 0.4897 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.538 | 0.5258 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.538 | 0.4897 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.019 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.019 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0112 | 0.538 | 0.5258 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2566 | 0.2566 |
Plasmodium vivax | unspecified product | 0.0058 | 0.2169 | 0.135 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1511 | 0.2809 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.3191 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3191 | 0.5931 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0058 | 0.2169 | 0.135 |
Echinococcus granulosus | cathepsin L | 0.0058 | 0.2169 | 0.3902 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.3191 | 0.3011 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0947 | 0.0708 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Onchocerca volvulus | Cathepsin L homolog | 0.0112 | 0.538 | 1 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0075 | 0.3191 | 0.5842 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.538 | 0.5258 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0947 | 0.1761 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1511 | 0.2652 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0037 | 0.0947 | 0.1761 |
Echinococcus multilocularis | cysteine protease | 0.0112 | 0.538 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1067 | 0.1984 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0112 | 0.538 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Brugia malayi | Cathepsin L-like precursor | 0.0075 | 0.3191 | 0.3011 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0921 | 0.153 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.019 | 1 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0112 | 0.538 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.019 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1511 | 0.2652 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0058 | 0.2169 | 0.135 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0112 | 0.538 | 0.41 |
Brugia malayi | Cathepsin L-like precursor | 0.0112 | 0.538 | 0.5258 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.019 | 1 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0112 | 0.538 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0037 | 0.0947 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0947 | 0.1761 |
Echinococcus granulosus | cathepsin l1 | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3191 | 0.5931 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0115 | 0.0115 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.538 | 0.4897 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.121 | 0.2249 |
Leishmania major | dihydroorotate dehydrogenase | 0.019 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0058 | 0.2169 | 0.2169 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0112 | 0.538 | 0.4897 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.019 | 1 | 0.5 |
Schistosoma mansoni | cathepsin s | 0.0037 | 0.0947 | 0.0947 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3014 | 0.5603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.019 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0075 | 0.3191 | 0.2478 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2351 | 0.4247 |
Plasmodium vivax | vivapain-2 | 0.0112 | 0.538 | 0.4897 |
Onchocerca volvulus | Cathepsin L homolog | 0.0112 | 0.538 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0112 | 0.538 | 0.538 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2351 | 0.4247 |
Echinococcus granulosus | cysteine protease | 0.0058 | 0.2169 | 0.3902 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0058 | 0.2169 | 0.2169 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0075 | 0.3191 | 0.3182 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1511 | 0.2652 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Echinococcus multilocularis | cathepsin L | 0.0058 | 0.2169 | 0.3902 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0058 | 0.2169 | 0.1962 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0058 | 0.2169 | 0.1962 |
Onchocerca volvulus | 0.0112 | 0.538 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Onchocerca volvulus | Cathepsin F homolog | 0.0112 | 0.538 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0112 | 0.538 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0112 | 0.538 | 0.41 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0075 | 0.3191 | 0.3191 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0112 | 0.538 | 0.538 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0074 | 0.3148 | 0.5761 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0075 | 0.3191 | 0.3011 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0112 | 0.538 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0074 | 0.3148 | 0.2431 |
Plasmodium vivax | vivapain-3 | 0.0058 | 0.2169 | 0.135 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0058 | 0.2169 | 0.135 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0074 | 0.3148 | 0.5761 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0074 | 0.3148 | 0.5761 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0074 | 0.3148 | 0.3048 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0075 | 0.3191 | 0.3182 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0074 | 0.3148 | 0.5761 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.538 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1063 | 0.0827 |
Plasmodium vivax | vivapain-1 | 0.0058 | 0.2169 | 0.135 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0112 | 0.538 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.