Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.4093 | 0.3759 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0058 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.4093 | 0.343 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.2084 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0022 | 0.215 | 0.1597 |
Brugia malayi | SH2 domain containing protein | 0.0022 | 0.215 | 0.1268 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0022 | 0.215 | 0.1597 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.4093 | 0.2539 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus granulosus | lamin | 0.0031 | 0.4093 | 0.3678 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0657 | 0.0128 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0022 | 0.215 | 0.1597 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.2084 | 0.1194 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0022 | 0.215 | 0.1597 |
Schistosoma mansoni | lamin | 0.0031 | 0.4093 | 0.2539 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.215 | 0.0083 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0022 | 0.215 | 0.1597 |
Onchocerca volvulus | 0.0031 | 0.4093 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0022 | 0.215 | 0.1597 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.215 | 0.1268 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0022 | 0.215 | 0.1597 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.4093 | 0.3678 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0058 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0022 | 0.215 | 0.1597 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.215 | 0.0083 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.4093 | 0.3678 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.2084 | 0.1527 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.215 | 0.0083 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0058 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.215 | 0.1268 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Onchocerca volvulus | 0.0031 | 0.4093 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0022 | 0.2263 | 0.1719 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.4093 | 0.3759 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.215 | 0.1268 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0022 | 0.215 | 0.1705 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.101 | 0.0501 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0022 | 0.215 | 0.1597 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0022 | 0.215 | 0.0083 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0058 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0022 | 0.215 | 0.1597 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.2084 | 0.1527 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0022 | 0.215 | 0.1597 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.2084 | 0.9693 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.215 | 0.1705 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0022 | 0.215 | 0.1597 |
Echinococcus multilocularis | lamin | 0.0031 | 0.4093 | 0.3678 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4093 | 0.3759 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0022 | 0.215 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus granulosus | tyrosine kinase | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine kinase | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0022 | 0.215 | 0.1597 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.215 | 0.1268 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0022 | 0.215 | 0.1268 |
Brugia malayi | SH2 domain containing protein | 0.0022 | 0.215 | 0.1268 |
Echinococcus granulosus | c src tyrosine kinase | 0.0022 | 0.215 | 0.1597 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.215 | 0.0083 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.2084 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0022 | 0.215 | 0.1597 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0022 | 0.215 | 0.1597 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.2084 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0058 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.4093 | 0.3678 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.2084 | 0.1635 |
Schistosoma mansoni | lamin | 0.0031 | 0.4093 | 0.2539 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus multilocularis | musashi | 0.0031 | 0.4093 | 0.3678 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.2084 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.215 | 0.0083 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.215 | 0.0083 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Brugia malayi | protein-tyrosine kinase | 0.0022 | 0.215 | 0.1268 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0022 | 0.215 | 0.1597 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.4093 | 0.343 |
Brugia malayi | hypothetical protein | 0.0022 | 0.215 | 0.1268 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0058 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0022 | 0.215 | 0.1597 |
Loa Loa (eye worm) | SRC-1 | 0.0022 | 0.215 | 0.1705 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0022 | 0.215 | 0.1597 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.215 | 0.1268 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.2084 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.2084 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0022 | 0.215 | 0.1597 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3972 | 0.363 |
Brugia malayi | SRC-1 | 0.0022 | 0.215 | 0.1268 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.215 | 0.1705 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.215 | 0.1597 |
Echinococcus multilocularis | tyrosine kinase | 0.0022 | 0.215 | 0.1597 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0058 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0022 | 0.215 | 0.1597 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0058 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0058 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0058 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0058 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.