Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0103 | 0.9017 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0103 | 0.9017 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0103 | 0.9017 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0103 | 0.9017 | 0.9017 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0104 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0103 | 0.9017 | 1 |
Onchocerca volvulus | 0.0103 | 0.9017 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0103 | 0.9017 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0103 | 0.9017 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0103 | 0.9017 | 0.9017 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0103 | 0.9017 | 0.9017 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0103 | 0.9017 | 0.9017 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0103 | 0.9017 | 0.9017 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | nuclear hormone receptor | 0.0103 | 0.9017 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0103 | 0.9017 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0103 | 0.9017 | 0.9017 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0103 | 0.9017 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0103 | 0.9017 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0103 | 0.9017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0103 | 0.9017 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0103 | 0.9017 | 0.9017 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0104 | 1 | 0.5 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0104 | 1 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0103 | 0.9017 | 0.9017 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | steroid hormone receptor | 0.0103 | 0.9017 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0103 | 0.9017 | 0.9017 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0103 | 0.9017 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0103 | 0.9017 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0103 | 0.9017 | 0.9017 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0104 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0103 | 0.9017 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0103 | 0.9017 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0103 | 0.9017 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0103 | 0.9017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0103 | 0.9017 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | ecdysteroid receptor | 0.0103 | 0.9017 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0103 | 0.9017 | 0.9017 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0103 | 0.9017 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0103 | 0.9017 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0103 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.9017 | 0.9017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.5 | Inhibition of mouse transglutaminase 2 using ((benzyloxy)carbony l)-L-glutaminylglycine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | < 1 | Inhibition of human transglutaminase 3 using ((benzyloxy)carbonyl)-L-glutaminyl-L-serine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 4.8 | Inhibition of human transglutaminase 1 using ((benzyloxy)carbonyl)-L-glutaminyl-L-serine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 11.1 | Inhibition of human factor 13a using QEQVSPLSLLK peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 12.5 | Inhibition of human transglutaminase 2 using ((benzyloxy)carbony l)-L-glutaminylglycine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
T1/2 (ADMET) | = 15 min | Half life in CD-1 mouse at 50 mg/kg, po | ChEMBL. | 25333388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.