Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.967 | 0.967 |
Schistosoma mansoni | alkaline phosphatase | 0.0159 | 0.9307 | 0.9307 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.967 | 1 |
Trichomonas vaginalis | phospholipase A-2-activating protein, putative | 0.0035 | 0.0532 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0159 | 0.9307 | 0.9307 |
Plasmodium falciparum | polyubiquitin binding protein, putative | 0.0035 | 0.0532 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.967 | 0.967 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.967 | 0.967 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0159 | 0.9307 | 0.9307 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | phospholipase A 2 activating protein | 0.0035 | 0.0532 | 0.0532 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0159 | 0.9307 | 0.9307 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0159 | 0.9307 | 0.9307 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.967 | 0.967 |
Trypanosoma cruzi | WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative | 0.0035 | 0.0532 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3892 | 0.3892 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0532 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.967 | 1 |
Echinococcus granulosus | phospholipase A 2 activating protein | 0.0035 | 0.0532 | 0.0532 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0159 | 0.9307 | 0.9307 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0159 | 0.9307 | 0.9307 |
Brugia malayi | WD domain containing protein | 0.0035 | 0.0532 | 0.055 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.967 | 0.967 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.967 | 0.967 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0159 | 0.9307 | 0.9307 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.967 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.967 | 0.967 |
Echinococcus multilocularis | alkaline phosphatase | 0.0159 | 0.9307 | 0.9307 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus granulosus | alkaline phosphatase | 0.0159 | 0.9307 | 0.9307 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.967 | 1 |
Trypanosoma cruzi | WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative | 0.0035 | 0.0532 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Toxoplasma gondii | PUL domain-containing protein | 0.0035 | 0.0532 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.967 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.967 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.94 nM | Inhibition of human recombinant AChE after 5 mins by Ellman method | ChEMBL. | 25259726 |
IC50 (binding) | = 234 nM | Inhibition of human plasmatic BChE after 5 mins by Ellman method | ChEMBL. | 25259726 |
Inhibition (binding) | = 52.8 % | Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) at 10 uM after 24 hrs by thioflavin T fluorescence method | ChEMBL. | 25259726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.