Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0137 | 0.5062 | 0.5062 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.4546 | 0.4546 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0106 | 0.2905 | 0.2905 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.4546 | 0.4546 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.2905 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.0467 | 0.0467 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.5062 | 0.5062 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0106 | 0.2905 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.0467 | 0.0467 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0106 | 0.2905 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.5062 | 0.5062 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.2905 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4546 | 0.4546 |
Giardia lamblia | Kinase, PLK | 0.0106 | 0.2905 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.9424 | 0.9424 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0201 | 0.9424 | 0.9424 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0201 | 0.9424 | 0.9424 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0201 | 0.9424 | 0.9424 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0106 | 0.2905 | 0.2905 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0106 | 0.2905 | 0.2905 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4546 | 0.4546 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4546 | 0.4546 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.2905 | 0.2905 |
Brugia malayi | RNA binding protein | 0.013 | 0.4546 | 0.4546 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.4546 | 0.4546 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4546 | 0.4546 |
Trypanosoma brucei | polo-like protein kinase | 0.0106 | 0.2905 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4546 | 0.4546 |
Brugia malayi | TAR-binding protein | 0.013 | 0.4546 | 0.4546 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.4546 | 0.4546 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.0467 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.4546 | 0.4546 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0106 | 0.2905 | 0.2905 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2905 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.4546 | 0.4546 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.43 uM | Inhibition of human recombinant his6-tagged DPP4 using Ala-Pro-AMC as substrate by continuous fluorometric method | ChEMBL. | 25457126 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.