Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione reductase | 0.0097 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0097 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0097 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0097 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0055 | 0.2603 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0055 | 0.2603 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0097 | 1 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0097 | 1 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0055 | 0.2603 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0055 | 0.2603 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0055 | 0.2603 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0055 | 0.2603 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0097 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0097 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0055 | 0.2603 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0097 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0097 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0097 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0097 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0055 | 0.2603 | 0.2603 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0055 | 0.2603 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0055 | 0.2603 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0055 | 0.2603 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0097 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0097 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0055 | 0.2603 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against human PBMC | ChEMBL. | 25458500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.