TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.383 | Formula: C20H20N2O5
H donors: 1 H acceptors: 1 LogP: 2.45 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1c[nH]c(=O)c(n1)c1cc(OC)c(c(c1)OC)OC
InChi: 1S/C20H20N2O5/c1-24-14-7-5-12(6-8-14)15-11-21-20(23)18(22-15)13-9-16(25-2)19(27-4)17(10-13)26-3/h5-11H,1-4H3,(H,21,23)
InChiKey: DZLJQGOPPJWNBC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0093	0.0199	0.0199
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0335	0.1256	0.1296
Schistosoma mansoni	amine GPCR	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	ORL1-like opioid receptor	0.0093	0.0199	0.0132
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0199	0.0199
Onchocerca volvulus	Poor gastrulation protein homolog	0.0212	0.072	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0891	0.3682	0.3682
Loa Loa (eye worm)	glutamate receptor	0.1306	0.5492	0.5693
Echinococcus multilocularis	somatostatin receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	Biotin lipoyl attachment	0.0082	0.0153	0.0153
Schistosoma mansoni	pyruvate carboxylase	0.0891	0.3682	0.3682
Brugia malayi	Dopamine receptor protein 2	0.0093	0.0199	0.0132
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0093	0.0199	0.02
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.2257	0.9643	1
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.0201	0.0674	0.0674
Mycobacterium leprae	Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)	0.0317	0.1178	0.2905
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0127	0.0347	0.0353
Schistosoma mansoni	acetyl-CoA carboxylase	0.2339	1	1
Echinococcus multilocularis	glutamate receptor 2	0.0123	0.0331	0.0331
Schistosoma mansoni	hypothetical protein	0.0093	0.0199	0.0199
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	G protein coupled receptor 139	0.0093	0.0199	0.0199
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	cytochrome P450 family protein	0.0064	0.0073	0.0068
Schistosoma mansoni	amine GPCR	0.0093	0.0199	0.0199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.067	0.2721	0.2721
Echinococcus granulosus	Biotin lipoyl attachment	0.0082	0.0153	0.0153
Brugia malayi	Serotonin receptor	0.0093	0.0199	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0331	0.0336
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.0201	0.0674	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0331	0.0336
Brugia malayi	Serotonin receptor	0.0093	0.0199	0.0132
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0891	0.3682	0.3584
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Echinococcus granulosus	glutamate receptor 2	0.0123	0.0331	0.0331
Echinococcus granulosus	neuropeptide s receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	7tm_1 domain containing protein	0.0093	0.0199	0.0199
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.0891	0.3682	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0212	0.072	0.072
Mycobacterium tuberculosis	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)	0.0317	0.1178	0.2905
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.0201	0.0674	0.1476
Schistosoma mansoni	hypothetical protein	0.0093	0.0199	0.0199
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.0199	0.02
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	cathepsin D (A01 family)	0.0162	0.05	0.05
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E2	0.0082	0.0153	0.0069
Mycobacterium tuberculosis	Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6	0.0317	0.1178	0.2905
Plasmodium falciparum	dihydrolipoamide acyltransferase component E2	0.0082	0.0153	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Onchocerca volvulus	Tyrosine kinase homolog	0.0176	0.0564	0.7003
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0123	0.0331	0.0331
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0127	0.0347	0.0353
Giardia lamblia	Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative	0.0399	0.1535	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Echinococcus multilocularis	g-protein coupled receptor	0.0093	0.0199	0.0199
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.0199	0.0199
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.1485	0.6273	0.6273
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0317	0.1178	0.172
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0093	0.0199	0.02
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0093	0.0199	0.0199
Brugia malayi	Carboxyl transferase domain containing protein	0.2257	0.9643	1
Schistosoma mansoni	opsin-like receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	g-protein coupled receptor	0.0093	0.0199	0.0199
Mycobacterium ulcerans	acetyl/propionyl CoA carboxylase subunit beta	0.0317	0.1178	0.2905
Echinococcus granulosus	hypothetical protein	0.0093	0.0199	0.0199
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0093	0.0199	0.0199
Brugia malayi	Dopamine receptor protein 1	0.0093	0.0199	0.0132
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0891	0.3682	0.3682
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0066	0.0084	0.0084
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 5 AccD5	0.0317	0.1178	0.2905
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.0891	0.3682	0.3584
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0093	0.0199	0.0199
Onchocerca volvulus		0.0167	0.0522	0.6208
Echinococcus multilocularis	dihydrolipoyllysine residue acetyltransferase	0.0082	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor	0.0082	0.0153	0.0084
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0093	0.0199	0.02
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4	0.0317	0.1178	0.2905
Toxoplasma gondii	2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein	0.0082	0.0153	0.0069
Brugia malayi	metabotropic glutamate receptor type 2	0.0636	0.2572	0.2612
Schistosoma mansoni	biogenic amine receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	sex peptide receptor	0.0093	0.0199	0.0199
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0093	0.0199	0.0132
Schistosoma mansoni	opsin-like receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	orexin receptor type 2	0.0093	0.0199	0.0199
Echinococcus granulosus	neuropeptide receptor A26	0.0093	0.0199	0.0199
Leishmania major	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0317	0.1178	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0032	0.0026
Brugia malayi	Dopamine receptor	0.0093	0.0199	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Chlamydia trachomatis	biotin carboxylase	0.0809	0.3325	1
Echinococcus multilocularis	serotonin receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Onchocerca volvulus		0.0127	0.0347	0.2842
Brugia malayi	putative neuropeptide receptor NPR1	0.0093	0.0199	0.0132
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0093	0.0199	0.0199
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.0891	0.3682	1
Treponema pallidum	pyruvate carboxylase subunit B	0.0082	0.0153	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0093	0.0199	0.0132
Echinococcus multilocularis	dihydrolipoyllysine residue succinyltransferase	0.0082	0.0153	0.0153
Echinococcus multilocularis	propionyl coenzyme A carboxylase beta chain	0.0317	0.1178	0.1178
Echinococcus multilocularis	roundabout 2	0.0054	0.0032	0.0032
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0093	0.0199	0.0199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0123	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0212	0.072	0.074
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Schistosoma mansoni	metabotropic glutamate receptor	0.1094	0.4568	0.4568
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0093	0.0199	0.0132
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0127	0.0347	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.0199	0.02
Brugia malayi	G-protein coupled receptor	0.0093	0.0199	0.0132
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0331	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	hypothetical protein	0.0093	0.0199	0.0199
Leishmania major	acetyl-CoA carboxylase, putative	0.2339	1	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.0199	0.0199
Trypanosoma cruzi	extracellular receptor, putative	0.0123	0.0331	0.0299
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0093	0.0199	0.0132
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4_2	0.0317	0.1178	0.2905
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0093	0.0199	0.0199
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0093	0.0199	0.0132
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0891	0.3682	1
Schistosoma mansoni	biogenic amine receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	hypothetical protein	0.0212	0.072	0.072
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0331	0.0336
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0123	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	neuropeptide F receptor	0.0093	0.0199	0.0132
Brugia malayi	follicle stimulating hormone receptor	0.0093	0.0199	0.0132
Echinococcus granulosus	metabotropic glutamate receptor 2	0.1094	0.4568	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0084	0.008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0093	0.0199	0.0132
Echinococcus granulosus	fmrfamide receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	amine GPCR	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.1607	0.6809	0.7059
Loa Loa (eye worm)	hypothetical protein	0.0335	0.1256	0.1296
Echinococcus granulosus	somatostatin receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.0199	0.0199
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0093	0.0199	0.0199
Echinococcus multilocularis	nmda type glutamate receptor	0.0123	0.0331	0.0331
Schistosoma mansoni	hypothetical protein	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0347	0.0353
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus multilocularis	glutamate receptor 2	0.0123	0.0331	0.0331
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0219	0.0751	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	putative neuropeptide receptor	0.0093	0.0199	0.0132
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0891	0.3682	0.5922
Mycobacterium leprae	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	0.0317	0.1178	0.2905
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Toxoplasma gondii	dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase	0.0082	0.0153	0.0069
Brugia malayi	RE15519p	0.0093	0.0199	0.0132
Schistosoma mansoni	adenoreceptor	0.0093	0.0199	0.0199
Plasmodium falciparum	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex	0.0082	0.0153	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	GnHR receptor homolog	0.0093	0.0199	0.0132
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	orexin receptor type 2	0.0093	0.0199	0.0199
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0123	0.0331	0.0331
Mycobacterium ulcerans	acetyl-/propionyl-CoA carboxylase subunit beta	0.0317	0.1178	0.2905
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.1183	0.4957	0.5103
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0093	0.0199	0.0199
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0093	0.0199	0.0132
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Wolbachia endosymbiont of Brugia malayi	Acetyl-CoA carboxylase, carboxyltransferase component	0.0317	0.1178	0.2905
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0212	0.072	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0066	0.0084	0.5
Wolbachia endosymbiont of Brugia malayi	carbamoyl phosphate synthase large subunit	0.0201	0.0674	0.1476
Echinococcus granulosus	neuropeptide receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	propionyl-CoA carboxylase beta chain mitochondrial precursor	0.0317	0.1178	0.1178
Leishmania major	carboxylase, putative	0.0891	0.3682	0.3584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Chlamydia trachomatis	acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	0.0317	0.1178	0.3233
Loa Loa (eye worm)	glutamate receptor	0.0514	0.2036	0.2106
Brugia malayi	neuropeptide F receptor	0.0093	0.0199	0.0132
Schistosoma mansoni	biogenic amine receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.1094	0.4568	0.4568
Schistosoma mansoni	cathepsin D (A01 family)	0.0162	0.05	0.05
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0219	0.0751	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0331	0.0336
Echinococcus multilocularis	neuropeptide s receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	dihydrolipoyllysine residue acetyltransferase	0.0082	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	sex peptide receptor	0.0093	0.0199	0.0199
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0123	0.0331	0.027
Echinococcus multilocularis	tyrosine kinase	0.0127	0.0347	0.0347
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0123	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	propionyl coenzyme A carboxylase beta chain	0.0317	0.1178	0.1178
Toxoplasma gondii	pyruvate carboxylase	0.0891	0.3682	0.3628
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0335	0.1256	0.1296
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0891	0.3682	0.3682
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0123	0.0331	0.0331
Schistosoma mansoni	myosin xvIII	0.0093	0.0199	0.0199
Schistosoma mansoni	neuropeptide f receptor 76f	0.0093	0.0199	0.0199
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.0891	0.3682	1
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.0082	0.0153	0.0153
Echinococcus granulosus	serotonin receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	TYRA-2 protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	aspartate carbamoyltransferase	0.0201	0.0674	0.0674
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0127	0.0347	0.0347
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	tyrosine kinase	0.0127	0.0347	0.0347
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.0199	0.0199
Onchocerca volvulus		0.0123	0.0331	0.2528
Echinococcus granulosus	dro:myosuppressin receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	metabotropic glutamate receptor	0.0636	0.2572	0.2572
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0066	0.0084	0.0084
Loa Loa (eye worm)	melatonin receptor type 1A	0.0093	0.0199	0.02
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.0199	0.0199
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0093	0.0199	0.0199
Leishmania major	carbamoyl-phosphate synthase, putative	0.0201	0.0674	0.0529
Brugia malayi	larval opioid receptor	0.0093	0.0199	0.0132
Echinococcus granulosus	GPCR family 3 C terminal	0.0212	0.072	0.072
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0891	0.3682	1
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0123	0.0331	0.0331
Schistosoma mansoni	memapsin-2 (A01 family)	0.0444	0.1731	0.1731
Brugia malayi	Guanylyl cyclase protein 23	0.0127	0.0347	0.0287
Echinococcus granulosus	glutamate receptor 2	0.0123	0.0331	0.0331
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0066	0.0084	0.0084
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0891	0.3682	1
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Brugia malayi	Receptor family ligand binding region containing protein	0.0335	0.1256	0.1236
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus granulosus	7TM GPCR rhodopsin	0.0093	0.0199	0.0199
Echinococcus granulosus	neuropeptide FF receptor 2	0.0093	0.0199	0.0199
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.0199	0.0199
Brugia malayi	hypothetical protein	0.0123	0.0331	0.027
Plasmodium vivax	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative	0.0082	0.0153	0.0096
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	neuropeptide receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.0082	0.0153	0.0153
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase	0.0082	0.0153	0.0153
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.0199	0.02
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0093	0.0199	0.0199
Trypanosoma cruzi	acetyl-CoA carboxylase, putative	0.0317	0.1178	0.172
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	opsin-like receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.2339	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0093	0.0199	0.0199
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Brugia malayi	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta	0.0082	0.0153	0.0084
Brugia malayi	sulfakinin receptor protein	0.0093	0.0199	0.0132
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0891	0.3682	0.3584
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0123	0.0331	0.0331
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0891	0.3682	0.5922
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.1607	0.6809	0.6809
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	nmda type glutamate receptor	0.0123	0.0331	0.0331
Brugia malayi	AKH receptor	0.0093	0.0199	0.0132
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0093	0.0199	0.0199
Trypanosoma brucei	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0317	0.1178	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.0199	0.0199
Toxoplasma gondii	dihydrolipoamide acyltransferase, putative	0.0082	0.0153	0.0069
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.0199	0.0199
Entamoeba histolytica	acetyl-coA carboxylase, putative	0.0399	0.1535	1
Echinococcus multilocularis	serotonin receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.0317	0.1178	0.172
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0093	0.0199	0.02
Schistosoma mansoni	amine GPCR	0.0093	0.0199	0.0199
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	metabotropic glutamate receptor 5	0.1607	0.6809	0.6809
Echinococcus granulosus	g protein coupled receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	cell adhesion molecule	0.0049	0.0007	0.0007
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0891	0.3682	1
Trypanosoma brucei	acetyl-CoA carboxylase	0.2339	1	1
Schistosoma mansoni	tyrosine kinase	0.0127	0.0347	0.0347
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.0201	0.0674	0.0674
Echinococcus granulosus	g protein coupled receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0891	0.3682	0.3682
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus multilocularis	dro:myosuppressin receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0123	0.0331	0.0331
Leishmania major	extracellular receptor, putative	0.0123	0.0331	0.0181
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	G protein coupled receptor 139	0.0093	0.0199	0.0199
Plasmodium falciparum	carbamoyl phosphate synthetase	0.0201	0.0674	0.0831
Trypanosoma brucei	glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative	0.0201	0.0674	0.0529
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0123	0.0331	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0153	0.0151
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0123	0.0331	0.0331
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.2339	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Trypanosoma cruzi	glutamine dependent carbamoyl-phosphate synthase, putative	0.0201	0.0674	0.0874
Toxoplasma gondii	carbamoylphosphate synthetase	0.0201	0.0674	0.0594
Trypanosoma cruzi	acetyl-CoA carboxylase	0.1448	0.6113	1
Toxoplasma gondii	biotin-requiring enzyme domain-containing protein	0.0082	0.0153	0.0069
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.1692	0.718	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	glutamate receptor NMDA	0.0123	0.0331	0.0331
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.0199	0.0199
Mycobacterium leprae	ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6	0.0317	0.1178	0.2905
Echinococcus granulosus	roundabout 2	0.0054	0.0032	0.0032
Brugia malayi	G-protein coupled receptor	0.0093	0.0199	0.0132
Mycobacterium ulcerans	acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3	0.0317	0.1178	0.2905
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0127	0.0347	0.2842
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.2339	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0093	0.0199	0.02
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.0199	0.0199
Brugia malayi	Receptor family ligand binding region containing protein	0.0127	0.0347	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0093	0.0199	0.0199
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0212	0.072	0.0676
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Echinococcus granulosus	allatostatin A receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0199	0.0199
Trypanosoma brucei	unspecified product	0.0586	0.2351	0.2232
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0066	0.0084	0.008
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.0199	0.0199
Brugia malayi	Melatonin receptor type 1A	0.0093	0.0199	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Brugia malayi	dihydrolipoamide S-acetyltransferase precursor, putative	0.0082	0.0153	0.0084
Echinococcus granulosus	g protein coupled receptor	0.0093	0.0199	0.0199
Mycobacterium ulcerans	pyruvate carboxylase	0.0891	0.3682	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Schistosoma mansoni	dihydrolipoamide S-acetyltransferase	0.0082	0.0153	0.0153
Trypanosoma cruzi	glutamine-dependent carbamoyl-phosphate synthetase, putative	0.0201	0.0674	0.0874
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0049	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.0199	0.0199
Schistosoma mansoni	amine GPCR	0.0093	0.0199	0.0199
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.0199	0.0199
Brugia malayi	hypothetical protein	0.0093	0.0199	0.0132
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.0199	0.02
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0093	0.0199	0.0199
Toxoplasma gondii	acyl-CoA carboxyltransferase beta chain, putative	0.0317	0.1178	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0153	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0153	0.0151
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.0199	0.0199
Plasmodium falciparum	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	0.0082	0.0153	0.0096
Echinococcus granulosus	receptor type guanylyl cyclase	0.0127	0.0347	0.0347
Echinococcus granulosus	tyrosine kinase	0.0127	0.0347	0.0347
Plasmodium vivax	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative	0.0082	0.0153	0.0096
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.0199	0.0199
Schistosoma mansoni	protein kinase	0.0127	0.0347	0.0347
Echinococcus multilocularis	allatostatin A receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0331	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.0199	0.0199
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0093	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0199	0.02
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0032	0.0026
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.1692	0.718	1
Brugia malayi	G protein-coupled receptor	0.0093	0.0199	0.0132
Schistosoma mansoni	histamine h1 receptor	0.0093	0.0199	0.0199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Brugia malayi	Metabotropic glutamate receptor precursor.	0.1306	0.5492	0.5663
Leishmania major	propionyl-coa carboxylase beta chain, putative	0.0317	0.1178	0.1041
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.0199	0.0199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0199	0.0199
Echinococcus granulosus	dihydrolipoyllysine residue succinyltransferase	0.0082	0.0153	0.0153

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 22 uM	Inhibition of human recombinant PDGFRbeta using poly(Ala,Glu,Lys,Tyr) substrate	ChEMBL.	25007344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3358991

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 946817