Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0061 | 0.0321 | 0.0357 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0089 | 0.1316 | 0.1461 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0061 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0321 | 0.0357 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0336 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0125 | 0.2572 | 0.2856 |
Mycobacterium leprae | putative cytochrome p450 | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0125 | 0.2572 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0089 | 0.1316 | 0.1461 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0061 | 0.0321 | 0.0357 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.1316 | 0.1316 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0287 | 0.8293 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0287 | 0.8293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.7576 | 0.8412 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0308 | 0.9005 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.2572 | 0.2856 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0061 | 0.0321 | 0.0357 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0061 | 0.0321 | 0.0357 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.2572 | 0.2856 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0052 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0061 | 0.0321 | 0.0357 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0052 | 0 | 0.5 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0061 | 0.0321 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0751 | 0.0833 |
Leishmania major | cytochrome p450-like protein | 0.0125 | 0.2572 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0061 | 0.0321 | 0.0357 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1316 | 0.1461 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0061 | 0.0321 | 0.0357 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0061 | 0.0321 | 0.0357 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0089 | 0.1316 | 0.1461 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0089 | 0.1316 | 0.1461 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0061 | 0.0321 | 0.0357 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0125 | 0.2572 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0061 | 0.0321 | 0.0357 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0061 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0308 | 0.9005 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0061 | 0.0321 | 0.0321 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0061 | 0.0321 | 0.0357 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0061 | 0.0321 | 0.0321 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0308 | 0.9005 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0061 | 0.0321 | 0.0321 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0061 | 0.0321 | 0.0321 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0061 | 0.0321 | 0.0357 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.2572 | 0.2856 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0061 | 0.0321 | 0.0357 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0308 | 0.9005 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.2572 | 0.2856 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0125 | 0.2572 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0089 | 0.1316 | 0.1461 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0125 | 0.2572 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 105 % | Cytotoxicity against human MCF7 cells assessed as cell viability at 15 uM after 72 hrs by Celltitre-glo assay | ChEMBL. | 25455492 |
Inhibition (binding) | Modulation of sirtuin 2 (unknown origin) by thermal shift assay | ChEMBL. | 25455492 | |
Inhibition (binding) | Inhibition of RAR-beta (unknown origin) assessed as change in DNA methylation | ChEMBL. | 25455492 | |
Inhibition (binding) | = 28 % | Inhibition of HDAC in human HeLa cell extract at 100 uM after 15 mins by fluorescence assay | ChEMBL. | 25455492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.