Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | fatty acid amide hydrolase | No references | |
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Trypanosoma cruzi | amidase, putative | fatty acid amide hydrolase | 579 aa | 467 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.5261 | 0.5261 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2958 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2958 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.5261 | 0.5261 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.5261 | 0.5261 |
Echinococcus granulosus | carboxylesterase 5A | 0.0203 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2958 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0203 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2958 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.2958 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.2958 | 1 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.2958 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0203 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2958 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.2958 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0203 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.2958 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0203 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.2958 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0203 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0203 | 1 | 1 |
Brugia malayi | amidase | 0.0123 | 0.5261 | 0.5261 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2958 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2958 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.2958 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.2958 | 0.5 |
Schistosoma mansoni | amidase | 0.0123 | 0.5261 | 0.5261 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.5261 | 0.5261 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.2958 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.2958 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2958 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.2958 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.5261 | 0.5261 |
Brugia malayi | Carboxylesterase family protein | 0.0203 | 1 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0.2958 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0203 | 1 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.2958 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2958 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.5261 | 0.5261 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.2958 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 76 % | Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate assessed as remaining activity at 10 uM | ChEMBL. | 25282655 |
IC50 (binding) | = 7.13 | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate | ChEMBL. | 25282655 |
IC50 (binding) | = 74 nM | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate | ChEMBL. | 25282655 |
IC50 (binding) | > 10000 nM | In Vitro Competitive Activity-Based Protein Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.