Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.5531 | 0.5531 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.5531 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 1 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.5531 | 0.5531 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 1 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.5531 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.5531 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.5531 | 0.5531 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.5531 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 1 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.5531 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | = 93 % | Clearance in human liver microsomes after 60 mins by HPLC analysis relative to hepatic blood flow | ChEMBL. | 25516791 |
Emax (binding) | = 54 % | Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production at 2 uM relative to dexamethasone | ChEMBL. | 25516791 |
IC50 (binding) | = 7 nM | Displacement of RU-486 from GR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (binding) | = 300 nM | Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production | ChEMBL. | 25516791 |
IC50 (binding) | = 1700 nM | Displacement of tetramethylrhodamine-labeled dexamethasone from PR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (ADMET) | = 2 uM | Inhibition of human recombinant CYP3A4 using 7-benzyloxy-4-(trifluoromethyl)-coumarin as substrate after 30 mins by fluorescence assay | ChEMBL. | 25516791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.