Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0096 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0096 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0096 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0055 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0096 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0055 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0096 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0055 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0096 | 1 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0096 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0096 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0096 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0055 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0096 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0096 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0055 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0096 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0096 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0055 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.68 | Inhibition of mouse transglutaminase 2 using ((benzyloxy)carbony l)-L-glutaminylglycine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | < 1 | Inhibition of human transglutaminase 3 using ((benzyloxy)carbonyl)-L-glutaminyl-L-serine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 10.6 | Inhibition of human factor 13a using QEQVSPLSLLK peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 20 | Inhibition of human transglutaminase 1 using ((benzyloxy)carbonyl)-L-glutaminyl-L-serine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 108 | Inhibition of human transglutaminase 2 using ((benzyloxy)carbony l)-L-glutaminylglycine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
T1/2 (ADMET) | = 15 min | Half life in CD-1 mouse at 50 mg/kg, po | ChEMBL. | 25333388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.