Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | free fatty acid receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.8646 | 0.8646 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.2236 | 0.2236 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.2236 | 0.3937 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.4963 | 0.4963 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.2241 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.2241 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.8646 | 0.8646 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.5679 | 0.5679 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.8646 | 0.8646 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.5679 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5679 | 0.5679 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.2241 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.2241 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.2236 | 0.3937 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.2236 | 0.4505 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4963 | 0.8739 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.4963 | 0.4963 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.4515 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.4963 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4963 | 0.8739 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.8646 | 0.8646 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.2236 | 0.4505 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4963 | 0.8739 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.2241 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.2241 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2236 | 0.2236 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.2241 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.4515 |
Brugia malayi | RNA binding protein | 0.0062 | 0.4963 | 0.4963 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.4515 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.4963 | 0.4963 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.2236 | 0.3937 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.2236 | 0.4505 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.2241 | 0.4515 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.4963 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.4963 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.2236 | 0.2236 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.2241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4963 | 0.8739 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.2236 | 0.4505 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.2241 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.4515 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.2241 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.2236 | 0.3937 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.4515 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.2236 | 0.4505 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.2241 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.2236 | 0.4505 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4963 | 0.8739 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.2236 | 0.2236 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.2241 | 0.3946 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10000 nM | Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization | ChEMBL. | 25380412 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.