Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transmembrane protease, serine 6 | Starlite/ChEMBL | References |
Homo sapiens | suppression of tumorigenicity 14 (colon carcinoma) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0681 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.134 | 0.1094 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0057 | 0.0681 | 0.0416 |
Echinococcus multilocularis | acetylcholinesterase | 0.0538 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.134 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.134 | 0.134 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.134 | 0.1094 |
Echinococcus granulosus | carboxylesterase 5A | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0091 | 0.134 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 1 | 1 |
Onchocerca volvulus | 0.0091 | 0.134 | 1 | |
Brugia malayi | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0276 | 0.0276 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0091 | 0.134 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0598 | 0.0332 |
Schistosoma mansoni | gliotactin | 0.0091 | 0.134 | 0.134 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0598 | 0.0332 |
Echinococcus granulosus | acetylcholinesterase | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0681 | 0.0416 |
Brugia malayi | Carboxylesterase family protein | 0.0538 | 1 | 1 |
Brugia malayi | SEA domain containing protein | 0.0057 | 0.0681 | 0.0416 |
Loa Loa (eye worm) | carboxylesterase | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0538 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0091 | 0.134 | 0.134 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.134 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.134 | 0.134 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0681 | 0.0681 |
Onchocerca volvulus | 0.0091 | 0.134 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0091 | 0.134 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.134 | 0.1094 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0538 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0538 | 1 | 1 |
Onchocerca volvulus | 0.0091 | 0.134 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0598 | 0.0332 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0091 | 0.134 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Onchocerca volvulus | 0.0091 | 0.134 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.134 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.134 | 0.1094 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0091 | 0.134 | 0.5 |
Onchocerca volvulus | 0.0091 | 0.134 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0091 | 0.134 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0538 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0091 | 0.134 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.134 | 0.1094 |
Brugia malayi | Muscle positioning protein 4 | 0.0057 | 0.0681 | 0.0416 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0091 | 0.134 | 0.134 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0598 | 0.0332 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.18 nM | Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | ChEMBL. | 25387268 |
Ki (binding) | = 0.74 nM | Inhibition of human recombinant matriptase-2 using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | ChEMBL. | 25387268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.