TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 313.394 | Formula: C18H23N3O2
H donors: 0 H acceptors: 2 LogP: 2.59 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(OCCCN2CCOCC2)nc(n1)c1ccccc1
InChi: 1S/C18H23N3O2/c1-15-14-17(20-18(19-15)16-6-3-2-4-7-16)23-11-5-8-21-9-12-22-13-10-21/h2-4,6-7,14H,5,8-13H2,1H3
InChiKey: HJDSPOTXQZRDDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Sigma-1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cpg binding protein	0.0033	0.0539	0.0516
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0053	0.0054
Brugia malayi	RNA binding protein	0.0142	0.3013	0.3054
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.005	0.0912	0.0909
Brugia malayi	mbt repeat family protein	0.0044	0.0774	0.0785
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0297	0.0294
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0223	0.4677
Onchocerca volvulus		0.0023	0.0297	0.2669
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0458	0.0461
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0223	0.5
Onchocerca volvulus		0.0044	0.0774	0.735
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.011	0.0107
Schistosoma mansoni	hypothetical protein	0.0451	1	1
Brugia malayi	conserved hypotetical protein	0.0011	0.0024	0.0024
Brugia malayi	orphan nuclear receptor NR2E1	0.0011	0.0024	0.0024
Echinococcus granulosus	lamin	0.0056	0.1045	0.1042
Entamoeba histolytica	hypothetical protein	0.004	0.068	1
Echinococcus multilocularis	tar DNA binding protein	0.0142	0.3013	0.3011
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0223	0.4312
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0297	0.0294
Schistosoma mansoni	tar DNA-binding protein	0.0142	0.3013	0.2996
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0353	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0373	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.3394
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0297	0.0298
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0011	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0014	0.0109	0.0107
Brugia malayi	Latrophilin receptor protein 2	0.0014	0.0109	0.0111
Loa Loa (eye worm)	TAR-binding protein	0.0142	0.3013	0.3052
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Brugia malayi	tailless protein	0.0011	0.0024	0.0024
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0297	0.0294
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0297	0.0273
Brugia malayi	ecdysone receptor	0.0011	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0391	0.0393
Schistosoma mansoni	hypothetical protein	0.0266	0.582	0.581
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0297	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0173	0.3696	0.3694
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.005	0.0912	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Loa Loa (eye worm)	nuclear hormone receptor	0.0011	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0051
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0014	0.0109	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0368	0.037
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.068	0.0657
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.005	0.0912	0.0924
Echinococcus granulosus	SAM and MBT domain containing protein	0.0044	0.0774	0.0772
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0014	0.0109	0.0111
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0046	0.0819	0.083
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0774	0.0782
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0297	0.0301
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0353	0.0249
Echinococcus granulosus	cpg binding protein	0.0033	0.0539	0.0537
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0037	0.0034
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.0024	0.0021
Brugia malayi	latrophilin 2 splice variant baaae	0.0031	0.0491	0.0497
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0373	0.0378
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0053	0.005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0297	0.0294
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.011	0.0107
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0373	0.027
Brugia malayi	hypothetical protein	0.0025	0.0353	0.0357
Brugia malayi	hypothetical protein	0.0016	0.015	0.0152
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0373	1
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.1045	0.1056
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0297	0.0294
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0297	0.0301
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0297	0.0273
Brugia malayi	nuclear hormone receptor family member odr-7	0.0011	0.0024	0.0024
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.0024	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0051
Schistosoma mansoni	hypothetical protein	0.0031	0.0491	0.0468
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.011	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0819	0.0828
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0297	0.0298
Echinococcus multilocularis	GPCR, family 2	0.0014	0.0109	0.0107
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0373	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.1303	0.1282
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0297	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0051
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0024	0.0021
Entamoeba histolytica	hypothetical protein	0.004	0.068	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0373	1
Schistosoma mansoni	sex comb on midleg homolog	0.0044	0.0774	0.0752
Brugia malayi	hypothetical protein	0.0011	0.0024	0.0024
Brugia malayi	TAR-binding protein	0.0142	0.3013	0.3054
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.0024	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0297	0.0301
Echinococcus multilocularis	musashi	0.0056	0.1045	0.1042
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0297	0.0298
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0024	0.0024
Schistosoma mansoni	sex comb on midleg homolog	0.0044	0.0774	0.0752
Brugia malayi	isocitrate dehydrogenase	0.0015	0.011	0.0111
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	0.9867	1
Schistosoma mansoni	tar DNA-binding protein	0.0142	0.3013	0.2996
Onchocerca volvulus		0.0056	0.1045	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0297	0.0301
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0142	0.3013	0.3052
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0297	0.0301
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0224
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.3394
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0044	0.0774	0.735
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0297	0.0298
Brugia malayi	hypothetical protein	0.0012	0.0053	0.0054
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0297	0.0294
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0297	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0368	0.037
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0297	0.0294
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0014	0.0109	0.0107
Brugia malayi	nuclear receptor RXR	0.0011	0.0024	0.0024
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0373	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0109	0.0085
Brugia malayi	nuclear receptor NHR-67	0.0011	0.0024	0.0024
Entamoeba histolytica	hypothetical protein	0.004	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0491	0.0494
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0014	0.0109	0.0108
Echinococcus granulosus	intermediate filament protein	0.0056	0.1045	0.1042
Leishmania major	hypothetical protein, conserved	0.0025	0.0353	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0373	0.0375
Echinococcus multilocularis	histone acetyltransferase MYST2	0.005	0.0912	0.0909
Schistosoma mansoni	hypothetical protein	0.0014	0.0109	0.0085
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0353	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.0024	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0109	0.0108
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0297	0.0294
Onchocerca volvulus		0.0056	0.1045	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0297	0.0273
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0391	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.3394
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0297	0.0301
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0297	0.0273
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0373	0.0378
Schistosoma mansoni	tar DNA-binding protein	0.0142	0.3013	0.2996
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0297	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0053	0.005
Schistosoma mansoni	myelin transcription factor 1 myt1	0.005	0.0912	0.089
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0297	0.0298
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0297	0.0273
Brugia malayi	hypothetical protein	0.0011	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0224
Loa Loa (eye worm)	RNA binding protein	0.0142	0.3013	0.3052
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	0.9867	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0024	0.0021
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0046	0.0819	0.0828
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0297	0.0301
Entamoeba histolytica	hypothetical protein	0.004	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.0227	0.4936	0.5001
Loa Loa (eye worm)	mbt repeat family protein	0.0044	0.0774	0.0782
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0199	0.3394
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Onchocerca volvulus		0.0032	0.0498	0.4647
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0053	0.0051
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0024	0.0024
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0373	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.0921
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0223	0.4677
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.011	0.0107
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0046	0.0819	0.083
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.114	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Brugia malayi	nuclear hormone receptor	0.0023	0.0297	0.0301
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.0024	0.0021
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0011	0.0024	0.0024
Echinococcus granulosus	histone acetyltransferase MYST2	0.005	0.0912	0.0909
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0353	0.0249
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.1045	0.1056
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.011	0.0111
Leishmania major	C-8 sterol isomerase-like protein	0.0445	0.9867	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0109	0.0085
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0458	0.0464
Onchocerca volvulus		0.0026	0.0373	0.342
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0037	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1022	0.1033
Echinococcus multilocularis	polycomb protein SCMH1	0.0044	0.0774	0.0772
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0011	0.0024	0.0022
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0498	0.0502
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0297	0.0301
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0053	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0297	0.0298
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0498	0.0505
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0373	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0373	1
Schistosoma mansoni	lamin	0.0056	0.1045	0.1023
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.011	0.0086
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0297	0.2669
Echinococcus multilocularis	lamin	0.0056	0.1045	0.1042
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0053	0.0054
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0044	0.0774	0.0772
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0297	0.0273
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0297	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0024	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.068	0.0677
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0297	0.0301
Brugia malayi	steroid hormone receptor	0.0023	0.0297	0.0301
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0297	0.0298
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.0024	0.0021
Loa Loa (eye worm)	DR-78	0.0011	0.0024	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0373	0.0375
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0373	0.5
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0391	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0445	0.9867	1
Echinococcus granulosus	GPCR family 2	0.0014	0.0109	0.0107
Brugia malayi	hypothetical protein	0.004	0.068	0.0689
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0297	0.0301
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0297	0.0298
Loa Loa (eye worm)	MBCTL1	0.005	0.0912	0.0921
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0224
Brugia malayi	RNA recognition motif domain containing protein	0.0142	0.3013	0.3054
Brugia malayi	ecdysteroid receptor	0.0023	0.0297	0.0301
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0297	0.0301
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.068	0.0677
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0297	0.0294
Echinococcus granulosus	lamin dm0	0.0056	0.1045	0.1042
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0173	0.3696	0.3694
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0297	0.0301
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0014	0.0109	0.0107
Schistosoma mansoni	tar DNA-binding protein	0.0142	0.3013	0.2996
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0297	0.0301
Echinococcus granulosus	polycomb protein SCMH1	0.0044	0.0774	0.0772
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0297	0.0273
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0445	0.9867	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0297	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0297	0.0298
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0373	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0297	0.0273
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0011	0.0024	0.0024
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0297	0.0273
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0297	0.0301
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0297	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1045	0.1056
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0297	0.0294
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0353	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0353	0.0249
Brugia malayi	nuclear hormone receptor	0.0011	0.0024	0.0024
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0044	0.0774	0.0752
Schistosoma mansoni	cpg binding protein	0.0033	0.0539	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Schistosoma mansoni	cpg binding protein	0.0032	0.0498	0.0475
Echinococcus multilocularis	cpg binding protein	0.0033	0.0539	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Schistosoma mansoni	lamin	0.0056	0.1045	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0353	0.0355
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.1045	0.1059
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.011	0.0107
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0373	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0109	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Brugia malayi	mbt repeat family protein	0.0044	0.0774	0.0785
Schistosoma mansoni	hypothetical protein	0.004	0.068	0.0657
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0297	0.0294
Schistosoma mansoni	coup transcription factor	0.0023	0.0297	0.0273
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0373	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Schistosoma mansoni	intermediate filament proteins	0.0056	0.1045	0.1023
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0297	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0373	0.0375
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0297	0.0301
Echinococcus multilocularis	lamin dm0	0.0056	0.1045	0.1042
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0297	0.0273
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0024	0.0021
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.011	0.0107
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0024	0.0021
Echinococcus granulosus	tar DNA binding protein	0.0142	0.3013	0.3011
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0053	0.0029
Brugia malayi	nuclear receptor RXR	0.0012	0.0053	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0051
Echinococcus multilocularis	dnaJ subfamily B	0.0451	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0224
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0373	0.0378
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0297	0.2669
Schistosoma mansoni	hypothetical protein	0.0011	0.0037	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0051
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0373	0.027
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0297	0.0294
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0024	0.0021
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0297	0.0294
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0012	0.0053	0.0054
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.011	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0022
Schistosoma mansoni	tar DNA-binding protein	0.0142	0.3013	0.2996
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0297	0.0294
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0353	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0373	0.027
Brugia malayi	intermediate filament protein	0.0056	0.1045	0.1059
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0297	0.2669

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 36.3 nM	Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in Dunkin Hartley guinea pig brain membranes after 180 mins by liquid scintillation counting analysis	ChEMBL.	25420090

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3358634

Bibliographic References

No literature references available for this target.

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Detailed information for compound 947505