Detailed information for compound 947509

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.405 | Formula: C19H23N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(OC/C=C/CN2CCOCC2)nc(n1)c1ccccc1
  • InChi: 1S/C19H23N3O2/c1-16-15-18(21-19(20-16)17-7-3-2-4-8-17)24-12-6-5-9-22-10-13-23-14-11-22/h2-8,15H,9-14H2,1H3/b6-5+
  • InChiKey: QFFJSANPIDHCJZ-AATRIKPKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0183 0.018
Brugia malayi beta-lactamase 0.0079 0.0215 0.1566
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0068 0.0182 0.0166
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0215 0.1122
Giardia lamblia Rrm3p helicase 0.317 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Brugia malayi aspartic protease BmAsp-2, identical 0.002 0.003 0.0217
Onchocerca volvulus 0.002 0.003 0.1388
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.012 0.0583
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.006 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0068 0.0182 0.0182
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0215 0.1122
Schistosoma mansoni nuclear hormone receptor 0.003 0.006 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0024 0.0174
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0104 0.0087
Schistosoma mansoni hypothetical protein 0.0365 0.112 0.112
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.006 0.0057
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.0105 0.0298 0.0298
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0031 0.008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0016 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.006 0.0439
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.0303 0.2205
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Echinococcus granulosus ferritin 0.0016 0.0017 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0042 0.0307
Schistosoma mansoni ferritin light chain 0.0016 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.0026 0.0047 0.0047
Toxoplasma gondii aspartyl protease ASP1 0.002 0.003 0.0074
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0068 0.0182 0.0166
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0187 0.0187
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.0484 0.0481
Schistosoma mansoni ferritin 0.0016 0.0017 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0011 0.0008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0422 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.0453 0.0453
Brugia malayi Latrophilin receptor protein 2 0.0049 0.012 0.0872
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0215 0.1122
Schistosoma mansoni hypothetical protein 0.317 1 1
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0183 0.0183
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.317 1 1
Echinococcus granulosus lamin dm0 0.0024 0.0042 0.0042
Plasmodium vivax JmjC domain containing protein 0.0018 0.0024 0.0358
Schistosoma mansoni hypothetical protein 0.0049 0.012 0.012
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0068 0.0182 0.0179
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0024 0.0174
Schistosoma mansoni coup transcription factor 0.003 0.006 0.006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.006 0.006
Onchocerca volvulus 0.0079 0.0215 1
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.0484 0.0484
Loa Loa (eye worm) steroid hormone receptor 0.003 0.006 0.0439
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0016 0.0016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0068 0.0182 0.0182
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0016 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0142 0.0142
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0007 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0184 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0182 0.0182
Brugia malayi Steroid receptor seven-up type 2 0.003 0.006 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.006 0.0057
Brugia malayi hypothetical protein 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.0014
Entamoeba histolytica hypothetical protein 0.0069 0.0184 0.0184
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0024 0.0007
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0028 0.0028
Loa Loa (eye worm) aspartic protease BmAsp-2 0.002 0.003 0.0217
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0079 0.0215 0.1566
Schistosoma mansoni hypothetical protein 0.0047 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.006 0.0439
Schistosoma mansoni hypothetical protein 0.0047 0.0116 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.006 0.0439
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Schistosoma mansoni nuclear receptor 0.0014 0.0011 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0215 0.0215
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0069 0.0184 0.0184
Schistosoma mansoni thyroid hormone receptor 0.003 0.006 0.006
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.002 0.003 0.0074
Schistosoma mansoni hypothetical protein 0.0049 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0115
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.006 0.28
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.006 0.0439
Echinococcus multilocularis expressed protein 0.0016 0.0017 0.0014
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0017 0.0778
Loa Loa (eye worm) hypothetical protein 0.0079 0.0215 0.1566
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Mycobacterium ulcerans lipase LipD 0.0079 0.0215 0.1122
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0215 0.0212
Brugia malayi beta-lactamase family protein 0.0079 0.0215 0.1566
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0142 0.1036
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0159 0.0142
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0298 0.2169
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0011 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0422 0.0419
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0574 0.1782 1
Brugia malayi MAP kinase sur-1 0.0056 0.0142 0.1036
Brugia malayi hypothetical protein 0.002 0.003 0.0217
Schistosoma mansoni hypothetical protein 0.0049 0.012 0.012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0422 0.3069
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.002 0.003 0.003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0115
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.0014
Schistosoma mansoni ferritin light chain 0.0016 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Brugia malayi nuclear receptor RXR 0.0016 0.0016 0.0115
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0042 0.0307
Toxoplasma gondii aspartyl protease ASP3 0.002 0.003 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0215 0.1122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.006 0.0439
Brugia malayi Eukaryotic aspartyl protease family protein 0.002 0.003 0.0217
Mycobacterium ulcerans hypothetical protein 0.0163 0.0481 0.2629
Onchocerca volvulus 0.0016 0.0017 0.0778
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Entamoeba histolytica cysteine protease, putative 0.0016 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0068 0.0182 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0028 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.006 0.006
Echinococcus granulosus tumor protein p63 0.0301 0.0919 0.0919
Mycobacterium ulcerans hypothetical protein 0.0079 0.0215 0.1122
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0024 0.0024
Brugia malayi ecdysone receptor 0.0014 0.0011 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0187 0.1363
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.006 0.28
Loa Loa (eye worm) hypothetical protein 0.0036 0.0079 0.0575
Mycobacterium tuberculosis Conserved protein 0.0079 0.0215 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0122 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Brugia malayi nuclear receptor NHR-88 0.003 0.006 0.0439
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.002 0.003 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0017 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0142 0.0126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0028 0.0059
Loa Loa (eye worm) hypothetical protein 0.0445 0.1374 1
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0174
Echinococcus granulosus GPCR family 2 0.0049 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.006 0.0439
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0187 0.0187
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.012 0.0117
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0422 0.0422
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0053 0.0037
Echinococcus multilocularis geminin 0.0162 0.0478 0.0476
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0328 0.0328
Onchocerca volvulus 0.0024 0.0042 0.1961
Loa Loa (eye worm) hypothetical protein 0.0158 0.0466 0.3396
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0215 0.0215
Plasmodium falciparum plasmepsin II 0.002 0.003 0.9014
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0024 0.0007
Plasmodium falciparum plasmepsin IX 0.002 0.003 0.9014
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.1374 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0053 0.0205
Onchocerca volvulus Bile acid receptor homolog 0.003 0.006 0.28
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.006 0.0439
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0017 0.0778
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0142 0.0126
Loa Loa (eye worm) cysteine protease 0.0016 0.0017 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.006 0.0439
Echinococcus multilocularis ubiquitin specific protease 41 0.0068 0.0182 0.0179
Mycobacterium tuberculosis Conserved protein 0.0079 0.0215 0.1122
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0307
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0328 0.0326
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0011 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0215 0.1566
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0215 0.0215
Plasmodium falciparum plasmepsin I 0.002 0.003 0.9014
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.317 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0422 0.0422
Brugia malayi hypothetical protein 0.002 0.003 0.0217
Loa Loa (eye worm) DEAH box polypeptide 35 0.0036 0.0079 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0215 0.1122
Brugia malayi ecdysteroid receptor 0.003 0.006 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0215 0.0215
Plasmodium falciparum plasmepsin VI 0.002 0.003 0.9014
Echinococcus multilocularis FTZ F1 alpha 0.003 0.006 0.0057
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0011 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0021
Onchocerca volvulus 0.0016 0.0017 0.0778
Schistosoma mansoni hypothetical protein 0.0047 0.0116 0.0116
Onchocerca volvulus 0.0028 0.0053 0.248
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0016 0.0016
Schistosoma mansoni cathepsin D (A01 family) 0.002 0.003 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.006 0.0057
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0024 0.4874
Echinococcus multilocularis neuropeptide receptor A26 0.0412 0.127 0.1268
Brugia malayi MH2 domain containing protein 0.0106 0.0303 0.2205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0452 0.3287
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.006 0.006
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0122 0.0119
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0068 0.0182 0.0182
Plasmodium falciparum plasmepsin X 0.002 0.003 0.9014
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0017 0.0017
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0142 0.014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0104 0.008
Echinococcus multilocularis GPCR, family 2 0.0049 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0215 0.0199
Toxoplasma gondii ABC1 family protein 0.0079 0.0215 0.1124
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0024 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0215 0.0215
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0184 0.0184
Plasmodium vivax aspartyl protease, putative 0.002 0.003 0.0662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.0159 0.0142
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0011 0.0011
Onchocerca volvulus 0.0079 0.0215 1
Onchocerca volvulus 0.002 0.003 0.1388
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0122
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0142 0.0126
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0031 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.006 0.0057
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0011 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0122 0.0885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Schistosoma mansoni lamin 0.0024 0.0042 0.0042
Plasmodium falciparum plasmepsin VII 0.002 0.003 0.9014
Brugia malayi hypothetical protein 0.0014 0.0011 0.0077
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0228
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0187 0.0187
Loa Loa (eye worm) ctsf protein 0.0016 0.0017 0.0122
Onchocerca volvulus 0.003 0.006 0.28
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0574 0.1782 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0122
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0215 0.1122
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0217
Plasmodium vivax aspartyl proteinase, putative 0.002 0.003 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.006 0.0439
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.006 0.0439
Brugia malayi beta-lactamase family protein 0.0079 0.0215 0.1566
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0011 0.0011
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.0944 0.0929
Loa Loa (eye worm) DR-78 0.0014 0.0011 0.0077
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0142 0.0142
Brugia malayi jmjC domain containing protein 0.0068 0.0183 0.1329
Echinococcus granulosus ubiquitin specific protease 41 0.0068 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0049 0.0122 0.0885
Leishmania major cathepsin L-like protease 0.0061 0.0159 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0053 0.0205
Echinococcus multilocularis cpg binding protein 0.0027 0.0052 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0422 0.0419
Schistosoma mansoni patched 1 0.0049 0.0122 0.0122
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.1374 0.1359
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0017 0.0017
Echinococcus granulosus cpg binding protein 0.0027 0.0052 0.0052
Plasmodium vivax aspartyl protease, putative 0.002 0.003 0.0662
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0053 0.0205
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0122 0.0122
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0053 0.0053
Loa Loa (eye worm) beta-lactamase 0.0079 0.0215 0.1566
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0028 0.0026
Leishmania major hypothetical protein, conserved 0.0079 0.0215 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Brugia malayi CHE-14 protein 0.0049 0.0122 0.0885
Entamoeba histolytica hypothetical protein 0.0069 0.0184 0.0184
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0215 0.1566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0122
Echinococcus multilocularis microtubule associated protein 2 0.0615 0.1913 0.191
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0016 0.0017 0.5
Schistosoma mansoni lamin 0.0024 0.0042 0.0042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.317 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.012 0.0872
Brugia malayi jmjC domain containing protein 0.007 0.0187 0.1363
Echinococcus multilocularis ferritin 0.0016 0.0017 0.0014
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0011 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0053 0.0205
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0079 0.0215 0.1566
Onchocerca volvulus 0.0014 0.0011 0.0489
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Echinococcus granulosus cathepsin l1 0.0016 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Onchocerca volvulus 0.0016 0.0017 0.0778
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.006 0.0439
Schistosoma mansoni cellular tumor antigen P53 0.0044 0.0106 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.012 0.0872
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0047 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Echinococcus granulosus geminin 0.0162 0.0478 0.0478
Brugia malayi Cytochrome P450 family protein 0.005 0.0124 0.0905
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.006 0.0057
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0028 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0159 0.0142
Onchocerca volvulus 0.0014 0.0011 0.0489
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.317 1 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0024 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.006 0.0439
Toxoplasma gondii aspartyl protease 0.002 0.003 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.006 0.0439
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0024 0.004
Plasmodium vivax plasmepsin V, putative 0.002 0.003 0.0662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Mycobacterium leprae Probable lipase LipE 0.0079 0.0215 0.1122
Schistosoma mansoni ferritin 0.0016 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0142 0.0142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.006 0.0439
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0068 0.0182 0.1326
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0159 0.0142
Plasmodium falciparum plasmepsin V 0.002 0.003 0.9014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0944 0.0929
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0122 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Brugia malayi nuclear receptor RXR 0.0014 0.0011 0.0077
Echinococcus granulosus intermediate filament protein 0.0024 0.0042 0.0042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0047 0.0343
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0053 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.006 0.0439
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0024 0.0024
Brugia malayi nuclear receptor NHR-88 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0422 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0017 0.0017
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.002 0.003 0.0074
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0024 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0944 0.0929
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0016 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0016 0.0115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0389
Brugia malayi CXXC zinc finger family protein 0.0026 0.0047 0.0343
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0124 0.0905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0028 0.0059
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0174
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.006 0.0439
Brugia malayi aspartic protease BmAsp-1, identical 0.002 0.003 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0104 0.0087
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Brugia malayi nuclear hormone receptor 0.0014 0.0011 0.0077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.012 0.0872
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0429 0.0413
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0016 0.0115
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0068 0.0182 0.0159
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0215 0.1122
Echinococcus multilocularis dnaJ subfamily B 0.0365 0.112 0.1117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0162 0.0478 0.0478
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0142 0.0126
Plasmodium vivax aspartyl protease, putative 0.002 0.003 0.0662
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0142 0.0142
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0215 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.006 0.006
Echinococcus granulosus microtubule associated protein 2 0.0615 0.1913 0.1913
Schistosoma mansoni thyroid hormone receptor 0.003 0.006 0.006
Echinococcus granulosus dnaJ subfamily B 0.0365 0.112 0.112
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0104 0.0087
Echinococcus multilocularis expressed conserved protein 0.0108 0.0306 0.0304
Loa Loa (eye worm) hypothetical protein 0.0227 0.0685 0.4991
Echinococcus multilocularis protein patched 0.0049 0.0122 0.0119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0452 0.3287
Brugia malayi steroid hormone receptor 0.003 0.006 0.0439
Loa Loa (eye worm) aspartic protease BmAsp-1 0.002 0.003 0.0217
Schistosoma mansoni hypothetical protein 0.0162 0.0478 0.0478
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0053 0.0205
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.006 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0215 0.1122
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0017 0.0122
Schistosoma mansoni cathepsin D (A01 family) 0.002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Entamoeba histolytica hypothetical protein 0.0069 0.0184 0.0184
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0007 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.006 0.0439
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0011 0.0077
Echinococcus multilocularis lamin 0.0024 0.0042 0.0039
Trichomonas vaginalis esterase, putative 0.0079 0.0215 0.0215
Onchocerca volvulus 0.0079 0.0215 1
Schistosoma mansoni cpg binding protein 0.0027 0.0052 0.0052
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0011 0.0008
Brugia malayi nuclear hormone receptor 0.003 0.006 0.0439
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.1374 0.1359
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0011 0.0077
Echinococcus multilocularis lamin dm0 0.0024 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0106 0.0769
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0068 0.0182 0.0182
Brugia malayi Pepsin A precursor 0.002 0.003 0.0217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0153 0.0452 0.3287
Echinococcus granulosus lamin 0.0024 0.0042 0.0042
Trichomonas vaginalis ferritin, putative 0.0016 0.0017 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0042 0.0307
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0142 0.0126
Echinococcus granulosus expressed protein 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0217
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0053 0.0205
Leishmania major cathepsin L-like protease 0.0061 0.0159 0.0142
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.006 0.006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0215 0.1566
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0068 0.0182 0.1326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Plasmodium vivax aspartyl proteinase, putative 0.002 0.003 0.0662
Echinococcus granulosus expressed conserved protein 0.0108 0.0306 0.0306
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.006 0.0157 0.114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0011 0.0077
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Toxoplasma gondii hypothetical protein 0.005 0.0124 0.0607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Schistosoma mansoni nuclear receptor 0.0014 0.0011 0.0011
Brugia malayi intermediate filament protein 0.0024 0.0042 0.0307
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0068 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0228
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.006 0.006
Echinococcus granulosus FTZ F1 alpha 0.003 0.006 0.006
Brugia malayi hypothetical protein 0.0016 0.0016 0.0115
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.1374 0.1353
Loa Loa (eye worm) transcription factor SMAD2 0.0106 0.0303 0.2205
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0183 0.018
Echinococcus multilocularis musashi 0.0024 0.0042 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0053 0.0205
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0017 0.0778
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0158 0.0466 0.3396
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0053 0.0037
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0429 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Onchocerca volvulus 0.0016 0.0017 0.0778
Mycobacterium tuberculosis Conserved protein 0.0079 0.0215 0.1122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0011 0.0489
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0228
Toxoplasma gondii pantoate-beta-alanine ligase 0.0574 0.1782 1
Schistosoma mansoni zinc finger protein 0.0014 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0011 0.0008
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.317 1 1
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0024 0.0024
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0003 0.0003
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0142 0.014
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.006 0.006
Trypanosoma brucei protein kinase, putative 0.0056 0.0142 0.0119
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.317 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0011 0.0077
Plasmodium falciparum plasmepsin III 0.002 0.003 0.9014
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0011 0.0011
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0142 0.0119
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0068 0.0182 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0215 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0142 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0389
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0174
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0011
Onchocerca volvulus 0.0044 0.0106 0.4909
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Mycobacterium ulcerans beta-lactamase 0.0079 0.0215 0.1122
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0031 0.008
Onchocerca volvulus 0.0024 0.0042 0.1961
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0481 0.2629
Echinococcus granulosus neuropeptide s receptor 0.0412 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.006 0.0439
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0017 0.0122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0068 0.0182 0.0182
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0011 0.0077
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0122
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.006 0.006
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0328 0.0328
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0053 0.0205
Loa Loa (eye worm) aspartyl protease 6 0.002 0.003 0.0217
Mycobacterium ulcerans hypothetical protein 0.0028 0.0053 0.0205
Brugia malayi hypothetical protein 0.0069 0.0184 0.134
Plasmodium falciparum plasmepsin IV 0.002 0.003 0.9014
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0115
Schistosoma mansoni intermediate filament proteins 0.0024 0.0042 0.0042
Brugia malayi Probable ATP-dependent helicase DHX35 0.0036 0.0079 0.0575
Plasmodium falciparum plasmepsin VIII, putative 0.002 0.003 0.9014
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0174
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.317 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0215 0.1122
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0068 0.0182 0.0166
Brugia malayi nuclear receptor NHR-67 0.0014 0.0011 0.0077
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0142 0.0126
Plasmodium vivax plasmepsin IV, putative 0.002 0.003 0.0662
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2331 0.7343 0.7343
Loa Loa (eye worm) hypothetical protein 0.0079 0.0215 0.1566
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0024 0.0024
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0024 0.0021
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.0944 0.0922
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0024 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0053 0.0389
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0017 0.0122
Brugia malayi hypothetical protein 0.0016 0.0016 0.0115
Schistosoma mansoni ferritin 0.0016 0.0017 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.006 0.006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0053 0.0205
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0024 0.0021
Entamoeba histolytica DNA repair and recombination protein, putative 0.317 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0503 0.1557 0.8727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0215 0.0215
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0053 0.0389
Echinococcus multilocularis neuropeptide s receptor 0.0412 0.127 0.1268
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0068 0.0182 0.004
Leishmania major hypothetical protein, conserved 0.0018 0.0024 0.0007
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.317 1 1
Schistosoma mansoni ferritin 0.0016 0.0017 0.0017
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0011 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0215 0.1122
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.006 0.0439
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0024 0.0024
Onchocerca volvulus 0.0026 0.0047 0.2191
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0134 0.0117
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0228
Entamoeba histolytica hypothetical protein, conserved 0.317 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0142 0.0142
Schistosoma mansoni apoferritin-2 0.0016 0.0017 0.0017
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.006 0.0439
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0215 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Schistosoma mansoni cpg binding protein 0.0027 0.0052 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.0439
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0215 0.0215
Treponema pallidum bacterioferrin (TpF1) 0.0016 0.0017 0.5
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0024 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0422 0.0422
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.006 0.006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0053 0.0205
Schistosoma mansoni hypothetical protein 0.0069 0.0184 0.0184
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0118 0.0101
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0328 0.2391
Schistosoma mansoni memapsin-2 (A01 family) 0.0502 0.1553 0.1553
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.006 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0053 0.0037
Echinococcus granulosus neuropeptide receptor A26 0.0412 0.127 0.127
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0142 0.0142
Schistosoma mansoni microtubule-associated protein tau 0.0615 0.1913 0.1913
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0142 0.0712
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.002 0.003 0.003
Echinococcus granulosus phd:f box containing protein 0.0018 0.0024 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0024 0.0174
Onchocerca volvulus 0.0016 0.0017 0.0778
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0053 0.0389
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.012 0.0117
Brugia malayi jmjC domain containing protein 0.0018 0.0024 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.0159 0.0135
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0429 0.0406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077
Onchocerca volvulus 0.0016 0.0017 0.0778
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.006 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0105 0.0298 0.2169
Schistosoma mansoni apoferritin-2 0.0016 0.0017 0.0017
Echinococcus multilocularis protein dispatched 1 0.0056 0.0144 0.0141
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0031 1
Schistosoma mansoni hypothetical protein 0.0049 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.006 0.0439
Onchocerca volvulus 0.0016 0.0017 0.0778
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.012 0.012
Loa Loa (eye worm) fibroinase 0.0016 0.0017 0.0122
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0079 0.0215 0.1566
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0011 0.0489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0017
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0031 0.0735
Brugia malayi conserved hypotetical protein 0.0014 0.0011 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0011 0.0011
Echinococcus multilocularis tumor protein p63 0.0301 0.0919 0.0917
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0422 0.3069
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.006 0.006
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0574 0.1782 1
Leishmania major cathepsin L-like protease 0.0061 0.0159 0.0142
Brugia malayi tailless protein 0.0014 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0114 0.0328 0.2391
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.317 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0452 0.3287
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0077

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 116 nM Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in Dunkin Hartley guinea pig brain membranes after 180 mins by liquid scintillation counting analysis ChEMBL. 25420090

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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