Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.524 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.3533 | 0.6742 |
Brugia malayi | RNA binding protein | 0.0199 | 0.524 | 0.524 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0261 | 0.0499 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0139 | 0.3533 | 0.3533 |
Echinococcus multilocularis | smad | 0.0025 | 0.0261 | 0.0499 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1393 | 0.2659 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0366 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.1393 | 0.2659 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.1393 | 0.2659 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3533 | 0.3533 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0261 | 0.0261 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0261 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.5376 | 0.5376 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.524 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.524 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0204 | 0.5376 | 0.5376 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0199 | 0.524 | 0.524 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.1393 | 0.1393 |
Loa Loa (eye worm) | RNA binding protein | 0.0199 | 0.524 | 0.524 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0261 | 0.0261 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0261 | 0.0499 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0261 | 0.0261 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.1393 | 0.2659 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0261 | 0.0499 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.1393 | 0.2659 |
Loa Loa (eye worm) | TAR-binding protein | 0.0199 | 0.524 | 0.524 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.1393 | 0.1393 |
Schistosoma mansoni | smad | 0.0025 | 0.0261 | 0.0499 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0261 | 0.0499 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1393 | 0.2659 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0261 | 0.0261 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.524 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1393 | 0.1393 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.524 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.1393 | 0.2659 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0261 | 0.0261 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0261 | 0.0499 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0261 | 0.0261 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1393 | 0.2659 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0261 | 0.0499 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0261 | 0.0499 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0204 | 0.5376 | 0.5376 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0366 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0261 | 0.0499 |
Echinococcus granulosus | smad | 0.0025 | 0.0261 | 0.0499 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0261 | 0.0499 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0261 | 0.0499 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0199 | 0.524 | 0.524 |
Echinococcus multilocularis | tar DNA binding protein | 0.0199 | 0.524 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.1393 | 0.2659 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0199 | 0.524 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0261 | 0.0261 |
Brugia malayi | Smad1 | 0.0025 | 0.0261 | 0.0261 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.1393 | 0.1393 |
Brugia malayi | TAR-binding protein | 0.0199 | 0.524 | 0.524 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1393 | 0.2659 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0204 | 0.5376 | 0.5376 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 17.7 % | Antiparasitic activity against Leishmania braziliensis assessed as inhibition of infection with mouse J774.A1 cells measured infected cells at 1 uM at 1 x 10'-7 M after 4 hrs | ChEMBL. | 25240731 |
IC50 (functional) | = 0.25 uM | Antiparasitic activity against Leishmania braziliensis assessed as inhibition of growth after 72 hrs | ChEMBL. | 25240731 |
IC50 (ADMET) | > 10 uM | Cytotoxicity against mouse J774.A1 cells | ChEMBL. | 25240731 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania braziliensis | ChEMBL23 | 25240731 | |
Mus musculus | ChEMBL23 | 25240731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.