Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0037 | 0.0044 | 0.0951 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0008 | 0.0008 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0017 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.0235 | 0.0228 |
Brugia malayi | Dihydrofolate reductase | 0.3073 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.0162 | 0.0162 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1175 | 0.3775 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0111 | 0.0103 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3073 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0111 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0026 | 0.0008 | 0.0008 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0051 | 0.0051 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.013 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0067 | 0.0067 |
Brugia malayi | hypothetical protein | 0.0274 | 0.082 | 0.0812 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3073 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0148 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0105 | 0.0105 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.0113 | 0.2773 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0027 | 0.0027 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0274 | 0.082 | 0.0813 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.0235 | 0.0228 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.0113 | 0.2773 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.0206 | 0.0199 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0274 | 0.082 | 0.0813 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1175 | 0.3775 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0105 | 0.0105 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0016 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0076 | 0.0076 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0058 | 0.0051 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3073 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0105 | 0.0097 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1175 | 0.3775 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3073 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0051 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0256 | 0.0256 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1175 | 0.3775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0387 | 0.0387 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3073 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0058 | 0.0051 |
Brugia malayi | hypothetical protein | 0.0142 | 0.0387 | 0.0379 |
Onchocerca volvulus | Huntingtin homolog | 0.0142 | 0.0387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0008 | 0.0008 |
Schistosoma mansoni | dihydrofolate reductase | 0.3073 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3073 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0026 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.013 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0044 | 0.0044 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0939 | 0.3002 | 0.2996 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1175 | 0.3775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0387 | 0.0387 |
Schistosoma mansoni | eyes absent homolog | 0.0102 | 0.0256 | 0.0256 |
Onchocerca volvulus | 0.0056 | 0.0105 | 0.2557 | |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0032 | 0.0027 | 0.0019 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0067 | 0.0059 |
Brugia malayi | Hemopexin family protein | 0.0037 | 0.0044 | 0.0036 |
Onchocerca volvulus | Huntingtin homolog | 0.0142 | 0.0387 | 1 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0256 | 0.0249 |
Echinococcus granulosus | dihydrofolate reductase | 0.3073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.082 | 0.082 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0148 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.019 | 0.019 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1175 | 0.3775 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0111 | 0.0111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.