Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 1 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0599 | 0.0599 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.5833 | 0.5833 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.9599 | 0.9599 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5833 | 0.5833 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.5833 | 0.5568 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.5833 | 0.5833 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.5833 | 0.5833 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 1 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.5833 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0029 | 0.5833 | 0.5833 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.9599 | 0.9039 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.9599 | 0.9599 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.8382 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.9599 | 0.9039 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5627 | 0.5627 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.5833 | 0.5833 |
Echinococcus multilocularis | lamin | 0.0029 | 0.5833 | 0.5833 |
Brugia malayi | hypothetical protein | 0.0039 | 0.9599 | 0.9574 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.8382 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.5833 | 0.5568 |
Onchocerca volvulus | 0.0029 | 0.5833 | 0.5 | |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0029 | 0.5833 | 0.5833 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.5833 | 0.5833 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 2 | Inhibition of human transglutaminase 2 using ((benzyloxy)carbony l)-L-glutaminylglycine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Ratio (binding) | = 12 | Inhibition of human transglutaminase 1 using ((benzyloxy)carbonyl)-L-glutaminyl-L-serine peptide substrate assessed as Kinh/Ki ratio by GDH coupled assay | ChEMBL. | 25333388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.