Detailed information for compound 947731

Basic information

Technical information
  • TDR Targets ID: 947731
  • Name: isoquinoline-1,5-diamine
  • MW: 159.188 | Formula: C9H9N3
  • H donors: 2 H acceptors: 1 LogP: 1.07 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc2c1ccnc2N
  • InChi: 1S/C9H9N3/c10-8-3-1-2-7-6(8)4-5-12-9(7)11/h1-5H,10H2,(H2,11,12)
  • InChiKey: KBJRTCUFZWERQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1-amino-5-isoquinolyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.528 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.008 0.008
Brugia malayi MH2 domain containing protein 0.0119 0.2038 0.2038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0013
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.528 0.528
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0233 0.5
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0093 0.0051
Mycobacterium ulcerans beta-lactamase 0.0038 0.0432 0.1144
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.017 0.3055 1
Brugia malayi hypothetical protein 0.0144 0.2546 0.2546
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2038 0.1973
Loa Loa (eye worm) beta-lactamase 0.0038 0.0432 0.0355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0671 0.0595
Loa Loa (eye worm) hypothetical protein 0.0212 0.3903 0.3854
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0432 0.0818
Schistosoma mansoni hypothetical protein 0.0078 0.123 0.1664
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.0355
Schistosoma mansoni survival motor neuron protein 0.0106 0.1784 0.2464
Brugia malayi ecdysteroid receptor 0.002 0.008 0.008
Mycobacterium leprae Probable lipase LipE 0.0038 0.0432 0.0704
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0397 0.0397
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.528 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0233 0.0233
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0177 0.0953
Echinococcus granulosus muscleblind protein 0.0165 0.2959 0.2902
Schistosoma mansoni hypothetical protein 0.0106 0.1784 0.2464
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.008 0.008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0233 0.0474
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.4492 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0671 0.0595
Schistosoma mansoni hypothetical protein 0.0036 0.0397 0.0458
Mycobacterium ulcerans hypothetical protein 0.0028 0.0233 0.0474
Onchocerca volvulus 0.0106 0.1784 0.4456
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0432 0.0509
Echinococcus multilocularis muscleblind protein 1 0.0165 0.2959 0.2902
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.3552 0.6435
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0177 0.0953
Schistosoma mansoni hypothetical protein 0.0036 0.0397 0.0458
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0432 0.0818
Brugia malayi Dihydrofolate reductase 0.017 0.3055 0.3055
Onchocerca volvulus 0.0038 0.0432 0.092
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0065 0.0969 1
Chlamydia trachomatis dihydrofolate reductase 0.017 0.3055 1
Schistosoma mansoni tar DNA-binding protein 0.0281 0.5268 0.7505
Brugia malayi nuclear receptor NHR-88 0.002 0.008 0.008
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0233 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0432 0.0355
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0233 0.0368
Echinococcus multilocularis geminin 0.0367 0.6993 0.6968
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.0355
Brugia malayi RNA recognition motif domain containing protein 0.0281 0.5268 0.5268
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.008 0.008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0432 0.0818
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.008 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0397 0.0319
Echinococcus multilocularis muscleblind protein 0.0165 0.2959 0.2902
Brugia malayi Steroid receptor seven-up type 2 0.002 0.008 0.008
Mycobacterium ulcerans lipase LipD 0.0038 0.0432 0.1144
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0065 0.0969 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2959 0.2902
Onchocerca volvulus 0.0028 0.0233 0.0401
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.3354 0.8563
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0065 0.0969 1
Echinococcus granulosus tumor protein p63 0.0355 0.6749 0.6723
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.528 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.2996 0.294
Loa Loa (eye worm) hypothetical protein 0.0519 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0432 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.008 0.008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0671 0.0671
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0432 0.1144
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0432 0.0818
Echinococcus granulosus survival motor neuron protein 1 0.0519 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0671 0.0854
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0432 0.0818
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0233 0.0715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0671 0.0854
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0233 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.008 0.008
Brugia malayi beta-lactamase family protein 0.0038 0.0432 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.528 1
Onchocerca volvulus 0.0038 0.0432 0.092
Toxoplasma gondii ABC1 family protein 0.0038 0.0432 0.322
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0065 0.0969 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0397 0.0319
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0233 0.0715
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.528 0.5242
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0713 0.0638
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0432 0.322
Brugia malayi Muscleblind-like protein 0.0165 0.2959 0.2959
Echinococcus multilocularis survival motor neuron protein 1 0.0519 1 1
Schistosoma mansoni tar DNA-binding protein 0.0281 0.5268 0.7505
Echinococcus multilocularis tar DNA binding protein 0.0281 0.5268 0.523
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0397 0.0319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0432 0.0509
Schistosoma mansoni tar DNA-binding protein 0.0281 0.5268 0.7505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.008 0.008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.008 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.008 0.008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0397 0.0319
Onchocerca volvulus 0.0167 0.2996 0.7628
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0233 0.0474
Brugia malayi dihydrofolate reductase family protein 0.017 0.3055 0.3055
Onchocerca volvulus Huntingtin homolog 0.0144 0.2546 0.6449
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0233 0.0474
Brugia malayi nuclear hormone receptor 0.002 0.008 0.008
Loa Loa (eye worm) dihydrofolate reductase 0.017 0.3055 0.2998
Brugia malayi hypothetical protein 0.0167 0.2996 0.2996
Loa Loa (eye worm) hypothetical protein 0.0144 0.2546 0.2485
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0397 0.0319
Schistosoma mansoni hypothetical protein 0.0036 0.0397 0.0458
Echinococcus granulosus tar DNA binding protein 0.0281 0.5268 0.523
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.008 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.3552 0.6435
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0233 0.0474
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0671 0.0595
Mycobacterium tuberculosis Conserved protein 0.0038 0.0432 0.0818
Mycobacterium ulcerans hypothetical protein 0.0038 0.0432 0.1144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0281 0.5268 0.523
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0233 0.0715
Brugia malayi N-terminal motif family protein 0.0212 0.3903 0.3903
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.1949 0.1884
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0013
Loa Loa (eye worm) hypothetical protein 0.0114 0.1949 0.1884
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0013
Schistosoma mansoni hypothetical protein 0.0036 0.0397 0.0458
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0397 0.0319
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0177 0.0953
Echinococcus multilocularis tumor protein p63 0.0355 0.6749 0.6723
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0233 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.1949 0.1949
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.1949 0.1949
Schistosoma mansoni hypothetical protein 0.0367 0.6993 1
Loa Loa (eye worm) TAR-binding protein 0.0281 0.5268 0.523
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0432 0.3866
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.008 0.008
Echinococcus granulosus GPCR family 2 0.0036 0.0397 0.0319
Echinococcus multilocularis dihydrofolate reductase 0.017 0.3055 0.2998
Leishmania major hypothetical protein, conserved 0.0038 0.0432 0.322
Loa Loa (eye worm) hypothetical protein 0.0165 0.2959 0.2902
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0671 0.0595
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0233 0.0233
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.017 0.3055 1
Brugia malayi hypothetical protein 0.0025 0.0177 0.0177
Loa Loa (eye worm) RNA binding protein 0.0281 0.5268 0.523
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.0355
Onchocerca volvulus Huntingtin homolog 0.0144 0.2546 0.6449
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0078 0.123 0.116
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0432 0.322
Schistosoma mansoni tar DNA-binding protein 0.0281 0.5268 0.7505
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0432 0.322
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0713 0.0916
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0432 0.0704
Schistosoma mansoni dihydrofolate reductase 0.017 0.3055 0.4303
Mycobacterium tuberculosis Conserved protein 0.0038 0.0432 0.0818
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0065 0.0969 1
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0671 0.0854
Brugia malayi steroid hormone receptor 0.002 0.008 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Mycobacterium tuberculosis Conserved protein 0.0038 0.0432 0.0818
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0233 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0177 0.0097
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.0355
Brugia malayi beta-lactamase 0.0038 0.0432 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.0355
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0432 0.0432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0671 0.0595
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0065 0.0969 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0233 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.008 0.008
Brugia malayi beta-lactamase family protein 0.0038 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.0367 0.6993 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.0355
Loa Loa (eye worm) hypothetical protein 0.0144 0.2546 0.2485
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.528 1
Echinococcus granulosus geminin 0.0367 0.6993 0.6968
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0432 0.1144
Onchocerca volvulus 0.0052 0.0713 0.1656
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.3354 0.6027
Echinococcus granulosus dihydrofolate reductase 0.017 0.3055 0.2998
Schistosoma mansoni tar DNA-binding protein 0.0281 0.5268 0.7505
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0233 0.0474
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0432 0.0818
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2038 0.1973
Brugia malayi TAR-binding protein 0.0281 0.5268 0.5268
Echinococcus multilocularis GPCR, family 2 0.0036 0.0397 0.0319
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0233 0.0368
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0212 0.3903 1
Brugia malayi RNA binding protein 0.0281 0.5268 0.5268
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0432 0.0355
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.008 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0154
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.017 0.3055 0.675
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.123 0.123
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0432 0.0355
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.528 1
Onchocerca volvulus 0.0038 0.0432 0.092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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