TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 240.683 | Formula: C12H13ClO3
H donors: 1 H acceptors: 2 LogP: 2.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C(=C)C(c1cccc(c1)Cl)O
InChi: 1S/C12H13ClO3/c1-3-16-12(15)8(2)11(14)9-5-4-6-10(13)7-9/h4-7,11,14H,2-3H2,1H3
InChiKey: PFQZKPPCYZEHIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	hypothetical protein	0.0067	0.0199	0.0035
Brugia malayi	Dopamine receptor	0.0067	0.0199	0.0153
Onchocerca volvulus		0.0068	0.0207	0.0033
Brugia malayi	Sushi domain	0.0068	0.0207	0.0161
Brugia malayi	GnHR receptor homolog	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	Furin 1	0.0234	0.1967	0.1833
Brugia malayi	Dopamine receptor protein 2	0.0067	0.0199	0.0153
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0067	0.0199	0.0035
Schistosoma mansoni	furin-1 (S08 family)	0.0431	0.4058	0.3959
Schistosoma mansoni	opsin-like receptor	0.0067	0.0199	0.0035
Echinococcus multilocularis	cyclin B	0.0103	0.0572	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	g protein coupled receptor	0.0067	0.0199	0.0035
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0137	0.0934	0.2384
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	WD40 repeat protein	0.0293	0.2595	0.256
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Onchocerca volvulus	Putative endochitinase	0.0073	0.0258	0.0245
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0137	0.0934	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Schistosoma mansoni	cyclin B	0.0103	0.0572	0.0415
Onchocerca volvulus		0.0293	0.2595	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0067	0.0199	0.0035
Onchocerca volvulus		0.0103	0.0572	0.1558
Echinococcus granulosus	g protein coupled receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0234	0.1967	0.1833
Mycobacterium ulcerans	chitinase/cellulase	0.0062	0.0144	0.5
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0068	0.0207	0.0161
Schistosoma mansoni	myosin xvIII	0.0067	0.0199	0.0035
Schistosoma mansoni	integrin alpha	0.0153	0.1105	0.0956
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.0199	0.0035
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0067	0.0199	0.0153
Trichomonas vaginalis	cyclin A, putative	0.0103	0.0572	0.0888
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0077	0.0297	0.0135
Onchocerca volvulus	Putative endochitinase	0.0073	0.0258	0.0245
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	proprotein convertase 2	0.0623	0.6092	0.6074
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0067	0.0199	0.0035
Mycobacterium tuberculosis	Possible chitinase	0.0062	0.0144	0.5
Loa Loa (eye worm)	endoprotease bli-4	0.0991	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	celfurPC protein	0.0799	0.7966	0.7956
Schistosoma mansoni	amine GPCR	0.0067	0.0199	0.0035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0067	0.0199	0.0045
Echinococcus granulosus	c4b binding protein beta chain	0.0068	0.0207	0.0043
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0067	0.0199	0.0153
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0067	0.0199	0.0153
Schistosoma mansoni	chromatin regulatory protein sir2	0.0137	0.0934	0.0782
Echinococcus granulosus	neuropeptide receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0067	0.0199	0.0045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Echinococcus granulosus	C type lectin domian containing protein	0.0068	0.0207	0.0043
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0067	0.0199	0.0153
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.0199	0.0045
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.0199	0.0035
Toxoplasma gondii	rhoptry neck protein RON1	0.0068	0.0207	0.6957
Echinococcus multilocularis	integrin alpha 3	0.0117	0.0726	0.0721
Trichomonas vaginalis	hypothetical protein	0.0192	0.1518	0.2512
Echinococcus multilocularis	integrin alpha ps	0.0068	0.021	0.0059
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.0199	0.0153
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0192	0.1518	0.2512
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.0199	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	sulfakinin receptor protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	Furin 1	0.0234	0.1967	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Schistosoma mansoni	opsin-like receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0067	0.0199	0.0035
Brugia malayi	Will die slowly protein	0.0293	0.2595	0.256
Schistosoma mansoni	amine GPCR	0.0067	0.0199	0.0035
Loa Loa (eye worm)	transcriptional regulator	0.0123	0.0794	0.0751
Schistosoma mansoni	hypothetical protein	0.0293	0.2595	0.2471
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Onchocerca volvulus	Putative endochitinase	0.0073	0.0258	0.0245
Toxoplasma gondii	rhoptry neck protein RON9	0.0068	0.0207	0.6957
Echinococcus granulosus	neuropeptide s receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0934	0.0891
Schistosoma mansoni	chromatin regulatory protein sir2	0.0123	0.0794	0.064
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Schistosoma mansoni	neuropeptide receptor	0.0465	0.4414	0.432
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0103	0.0572	0.0528
Brugia malayi	putative neuropeptide receptor	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	fmrfamide receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0077	0.0297	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Schistosoma mansoni	chromatin regulatory protein sir2	0.0123	0.0794	0.064
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0144	0.0098
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0067	0.0199	0.0153
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0067	0.0199	0.0153
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0067	0.0199	0.0153
Echinococcus multilocularis	neuropeptide receptor A26	0.0067	0.0199	0.0045
Loa Loa (eye worm)	microfilarial chitinase	0.0062	0.0144	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	integrin alpha ps	0.0068	0.021	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0572	0.0528
Loa Loa (eye worm)	TYRA-2 protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	integrin alpha ps	0.0068	0.021	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Brugia malayi	GCC2 and GCC3 family protein	0.0068	0.0207	0.0161
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Schistosoma mansoni	hypothetical protein	0.0067	0.0199	0.0035
Echinococcus multilocularis	serotonin receptor	0.0067	0.0199	0.0045
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.0199	0.0045
Echinococcus granulosus	dro:myosuppressin receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	hypothetical protein	0.0192	0.1518	0.1376
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0123	0.0794	0.1268
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0123	0.0794	0.0751
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.0199	0.0045
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.0199	0.0035
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0098	0.0524	0.0462
Brugia malayi	neuropeptide F receptor	0.0067	0.0199	0.0153
Echinococcus granulosus	sex peptide receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	adenoreceptor	0.0067	0.0199	0.0035
Echinococcus granulosus	allatostatin A receptor	0.0067	0.0199	0.0035
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0098	0.0524	0.0366
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0067	0.0199	0.0035
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0123	0.0794	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Schistosoma mansoni	amine GPCR	0.0067	0.0199	0.0035
Echinococcus multilocularis	neuropeptide s receptor	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0252
Brugia malayi	Dopamine receptor protein 1	0.0067	0.0199	0.0153
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0602	0.5875	1
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0192	0.1518	0.2512
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0234	0.1967	0.3284
Leishmania major	silent information regulator 2, putative	0.0123	0.0794	1
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0123	0.0794	1
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0103	0.0572	0.5868
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0123	0.0794	0.0807
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0234	0.1967	0.3284
Trichomonas vaginalis	cyclin B, putative	0.0103	0.0572	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.0199	0.0035
Trichomonas vaginalis	WD repeat domain, putative	0.0293	0.2595	0.4363
Brugia malayi	Protein set-1	0.0077	0.0297	0.0252
Giardia lamblia	Hypothetical protein	0.0123	0.0794	0.1951
Echinococcus granulosus	orexin receptor type 2	0.0067	0.0199	0.0035
Plasmodium vivax	SET domain protein, putative	0.0077	0.0297	1
Trichomonas vaginalis	cyclins, putative	0.0064	0.0164	0.0186
Echinococcus multilocularis	c4b binding protein beta chain	0.0068	0.0207	0.0055
Brugia malayi	Serotonin receptor	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0597	0.0552
Brugia malayi	G protein-coupled receptor F59B2.13	0.0067	0.0199	0.0153
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.0199	0.0035
Loa Loa (eye worm)	integrin alpha pat-2	0.0236	0.1983	0.1945
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Schistosoma mansoni	integrin alpha-ps	0.0068	0.021	0.0047
Echinococcus granulosus	G protein coupled receptor 139	0.0067	0.0199	0.0035
Schistosoma mansoni	growth hormone secretagogue receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Brugia malayi	follicle stimulating hormone receptor	0.0067	0.0199	0.0153
Echinococcus granulosus	7tm_1 domain containing protein	0.0067	0.0199	0.0035
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.0199	0.0035
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Echinococcus granulosus	g-protein coupled receptor	0.0067	0.0199	0.0035
Leishmania major	cyclin	0.0103	0.0572	0.5868
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0137	0.0934	0.1508
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Onchocerca volvulus		0.0068	0.0207	0.0033
Loa Loa (eye worm)	cyclin domain-containing protein	0.0064	0.0164	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	ORL1-like opioid receptor	0.0067	0.0199	0.0153
Trichomonas vaginalis	cyclin D, putative	0.0064	0.0164	0.0186
Echinococcus multilocularis	orexin receptor type 2	0.0067	0.0199	0.0045
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0602	0.5875	0.5806
Schistosoma mansoni	biogenic amine receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.0199	0.0153
Onchocerca volvulus		0.0068	0.0207	0.0033
Onchocerca volvulus		0.0068	0.0207	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	cyclin B3, putative	0.0064	0.0164	0.0186
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0234	0.1967	0.3284
Echinococcus multilocularis		0.0799	0.7966	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0067	0.0199	0.0153
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0123	0.0794	0.0807
Brugia malayi	AKH receptor	0.0067	0.0199	0.0153
Onchocerca volvulus		0.0068	0.0207	0.0033
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0067	0.0199	0.0045
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	cyclin B, putative	0.0103	0.0572	0.0888
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.0199	0.0045
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Brugia malayi	neuroendocrine convertase 1 precursor	0.0623	0.6092	0.6074
Loa Loa (eye worm)	hypothetical protein	0.012	0.0757	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	Melatonin receptor type 1A	0.0067	0.0199	0.0153
Echinococcus multilocularis	protein will die slowly	0.0293	0.2595	0.3116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Onchocerca volvulus	Putative endochitinase	0.0073	0.0258	0.0245
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0067	0.0199	0.0153
Echinococcus multilocularis	somatostatin receptor	0.0067	0.0199	0.0045
Brugia malayi	neuropeptide F receptor	0.0067	0.0199	0.0153
Brugia malayi	Endochitinase	0.0073	0.0258	0.0212
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0067	0.0199	0.0035
Trichomonas vaginalis	cyclin B, putative	0.0103	0.0572	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Schistosoma mansoni	amine GPCR	0.0067	0.0199	0.0035
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	sex peptide receptor	0.0067	0.0199	0.0045
Echinococcus granulosus	cyclin B	0.0103	0.0572	0.0415
Echinococcus granulosus	protein will die slowly	0.0293	0.2595	0.2471
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	endochitinase	0.0073	0.0258	0.0212
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0067	0.0199	0.0045
Trichomonas vaginalis	cyclins, putative	0.0103	0.0572	0.0888
Schistosoma mansoni	neuropeptide f receptor 76f	0.0067	0.0199	0.0035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.0199	0.0045
Onchocerca volvulus		0.0068	0.0207	0.0033
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.0199	0.0045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Entamoeba histolytica	chitinase, putative	0.0073	0.0258	0.1487
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0123	0.0794	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0067	0.0199	0.0035
Brugia malayi	endochitinase	0.0073	0.0258	0.0212
Schistosoma mansoni	histamine h1 receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0077	0.0297	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Schistosoma mansoni	hypothetical protein	0.0067	0.0199	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Echinococcus granulosus	furin	0.0991	1	1
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Echinococcus granulosus	neuropeptide FF receptor 2	0.0067	0.0199	0.0035
Echinococcus granulosus	7TM GPCR rhodopsin	0.0067	0.0199	0.0035
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.0199	0.0153
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.0199	0.0045
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0192	0.1518	0.2512
Schistosoma mansoni	biogenic amine receptor	0.0067	0.0199	0.0035
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Plasmodium falciparum	SET domain protein, putative	0.0077	0.0297	1
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	amine GPCR	0.0067	0.0199	0.0035
Loa Loa (eye worm)	proprotein convertase 2	0.0234	0.1967	0.193
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0103	0.0572	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0389	0.3608	0.3578
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	chitinase I	0.0073	0.0258	0.0212
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0109	0.0643	0.06
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0123	0.0794	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0465	0.4414	0.5447
Echinococcus granulosus	neuroendocrine convertase 2	0.0623	0.6092	0.6027
Onchocerca volvulus		0.0068	0.0207	0.0033
Trichomonas vaginalis	cyclin B, putative	0.0103	0.0572	0.0888
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0067	0.0199	0.0045
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.0199	0.0035
Onchocerca volvulus		0.0068	0.0207	0.0033
Echinococcus granulosus	chromatin regulatory protein sir2	0.0123	0.0794	0.064
Echinococcus granulosus	g protein coupled receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0123	0.0794	0.064
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0123	0.0794	1
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Giardia lamblia	High cysteine membrane protein Group 2	0.0368	0.3391	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0137	0.0934	0.1508
Echinococcus granulosus	somatostatin receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.0199	0.0045
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0067	0.0199	0.0045
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.0199	0.0045
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	Serotonin receptor	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0207	0.0161
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.0643	0.0487
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.0199	0.0035
Onchocerca volvulus		0.0068	0.0207	0.0033
Brugia malayi	pregnancy-associated plasma protein-A	0.0068	0.0207	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	serotonin receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	cyclins, putative	0.0103	0.0572	0.0888
Onchocerca volvulus		0.0068	0.0207	0.0033
Loa Loa (eye worm)	cuticular endochitinase	0.0073	0.0258	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0378	0.0333
Trichomonas vaginalis	cyclins, putative	0.0103	0.0572	0.0888
Schistosoma mansoni	opsin-like receptor	0.0067	0.0199	0.0035
Plasmodium falciparum	apical sushi protein	0.0068	0.0207	0.3203
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0137	0.0934	0.1508
Brugia malayi	G protein-coupled receptor	0.0067	0.0199	0.0153
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0572	0.0528
Echinococcus multilocularis	neuropeptide receptor	0.0465	0.4414	0.5447
Entamoeba histolytica	cyclin, putative	0.0103	0.0572	0.6482
Echinococcus granulosus	neuropeptide receptor A26	0.0067	0.0199	0.0035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Brugia malayi	Integrin alpha pat-2 precursor	0.0153	0.1105	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0067	0.0199	0.0045
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	neuropeptide receptor	0.0465	0.4414	0.432
Onchocerca volvulus	Putative endochitinase	0.0073	0.0258	0.0245
Echinococcus multilocularis	serotonin receptor	0.0067	0.0199	0.0045
Giardia lamblia	Furin precursor putative serine protease	0.0192	0.1518	0.4194
Trichomonas vaginalis	cyclins, putative	0.0103	0.0572	0.0888
Echinococcus multilocularis	neuroendocrine convertase 2	0.0623	0.6092	0.7598
Brugia malayi	larval opioid receptor	0.0067	0.0199	0.0153
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0067	0.0199	0.0153
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.0643	0.0487
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.0199	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0064	0.0164	0.0118
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0199	0.0035
Echinococcus multilocularis	C type lectin domian containing protein	0.0068	0.0207	0.0055
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.0199	0.0045
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	c4b-binding protein beta chain	0.0068	0.0207	0.0043
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0067	0.0199	0.0045
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0602	0.5875	0.732
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.0199	0.0045
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	biogenic amine receptor	0.0067	0.0199	0.0035
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0123	0.0794	0.1268
Schistosoma mansoni	chromatin regulatory protein sir2	0.0123	0.0794	0.064
Echinococcus multilocularis	g-protein coupled receptor	0.0067	0.0199	0.0045
Trichomonas vaginalis	cyclin D, putative	0.0064	0.0164	0.0186
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.0199	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0991	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0109	0.0643	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0137	0.0934	0.0986
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	integrin alpha 3	0.0117	0.0726	0.0572
Brugia malayi	hypothetical protein	0.0068	0.0207	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0116	0.071	0.0666
Giardia lamblia	G2/mitotic-specific cyclin B	0.0103	0.0572	0.1265
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0077	0.0297	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0137	0.0934	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0602	0.5875	1
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0164	0.0186
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0234	0.1967	0.3284
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Brugia malayi	G-protein coupled receptor	0.0067	0.0199	0.0153
Trichomonas vaginalis	cyclin B, putative	0.0064	0.0164	0.0186
Brugia malayi	G-protein coupled receptor	0.0067	0.0199	0.0153
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0199	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0234	0.1967	0.3284
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0067	0.0199	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.1518	0.2512
Echinococcus multilocularis	allatostatin A receptor	0.0067	0.0199	0.0045
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0067	0.0199	0.0035
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	hypothetical protein	0.0067	0.0199	0.0035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0991	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0234	0.1967	0.3284
Brugia malayi	hypothetical protein	0.0067	0.0199	0.0153
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0137	0.0934	0.0891
Schistosoma mansoni	hypothetical protein	0.0067	0.0199	0.0035
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.0199	0.0035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0199	0.0035
Mycobacterium ulcerans	chitinase/cellulase	0.0062	0.0144	0.5
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0109	0.0643	0.0614
Echinococcus multilocularis	dro:myosuppressin receptor	0.0067	0.0199	0.0045
Loa Loa (eye worm)	melatonin receptor type 1A	0.0067	0.0199	0.0153
Brugia malayi	RE15519p	0.0067	0.0199	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0199	0.0153
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.0199	0.0045
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.0199	0.0035
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0116	0.071	0.0666
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0199	0.0035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3358564

Bibliographic References

No literature references available for this target.

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Detailed information for compound 948448