Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0387 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0751 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0387 | 0.4054 | 0.4054 |
Plasmodium vivax | vivapain-3 | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0502 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Giardia lamblia | Hypothetical protein | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.5946 | 0.5946 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Plasmodium vivax | unspecified product | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0502 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0751 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0248 | 0.1791 | 0.1791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B-like cysteine proteinase 3 precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0502 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Plasmodium vivax | unspecified product | 0.0248 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0139 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0248 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0248 | 0.1791 | 0.1791 |
Schistosoma mansoni | cathepsin s | 0.0248 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0502 | 0.5946 | 0.5946 |
Echinococcus multilocularis | cysteine protease | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Giardia lamblia | Encystation-specific protease | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0502 | 0.5946 | 0.5946 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0139 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0739 | 0.9804 | 0.9804 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0387 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0248 | 0.1791 | 0.1791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0387 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cysteine protease | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0248 | 0.1791 | 0.1791 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0502 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1791 | 0.1791 |
Giardia lamblia | Hypothetical protein | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0751 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0502 | 0.5946 | 0.5946 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0248 | 0.1791 | 0.1791 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0387 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0211 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0502 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0502 | 0.5946 | 0.5946 | |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0751 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0387 | 0.4054 | 0.4054 |
Toxoplasma gondii | cathepsin CPL | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.5946 | 0.5946 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1791 | 0.1791 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0751 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0387 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0751 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0211 | 0.1183 | 0.1183 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0502 | 0.5946 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0502 | 0.5946 | 0.5946 |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0751 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (ADMET) | = 495 mg kg-1 | Dose required for 100%, 31 day survival of Plasmodium berghai inoculated mice. | ChEMBL. | 11689078 |
ED (ADMET) | = 185 mg kg-1 | Dose needed to increase the 100% survival of treated animals (mouse), to twice the number of days | ChEMBL. | 11689078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.