Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0045 | 0.0988 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.0988 | 0.0988 |
Echinococcus granulosus | carboxylesterase 5A | 0.0265 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0265 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0045 | 0.0988 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0265 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0265 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0265 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0181 | 0.6542 | 0.6163 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Echinococcus multilocularis | acetylcholinesterase | 0.0265 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.6542 | 0.6163 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0988 | 0.0988 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0988 | 0.0988 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.045 | 0.045 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0265 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Echinococcus multilocularis | acetylcholinesterase | 0.0265 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0.0988 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0.0988 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0988 | 0.0988 |
Onchocerca volvulus | 0.0045 | 0.0988 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.0988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Onchocerca volvulus | 0.0045 | 0.0988 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.0988 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Trypanosoma brucei | cytochrome P450, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.6542 | 0.6163 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0988 | 0.0988 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0045 | 0.0988 | 1 |
Echinococcus granulosus | geminin | 0.0181 | 0.6542 | 0.6163 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0988 | 0.0988 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0045 | 0.0988 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.045 | 0.045 |
Onchocerca volvulus | 0.0045 | 0.0988 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 23.6 % | Neuroprotective activity against human SH-SY5Y cells assessed as inhibition of H2O2-induced cellular damage at 10 uM after 24 hrs relative to control | ChEMBL. | 18788732 |
Activity (functional) | = 43 % | Neuroprotective activity against human SH-SY5Y cells assessed as inhibition of H2O2-induced cellular damage at 10 uM dosed 1 hr prior to H2O2 challenge after 24 hrs relative to control | ChEMBL. | 18788732 |
IC50 (ADMET) | = 100 uM | Cytotoxicity against mouse J774 cells after 48 hrs by MTT assay | ChEMBL. | 18788732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.