TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 199.336 | Formula: C11H25N3
H donors: 2 H acceptors: 0 LogP: 2.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCNN1CCNCC1
InChi: 1S/C11H25N3/c1-2-3-4-5-6-7-13-14-10-8-12-9-11-14/h12-13H,2-11H2,1H3
InChiKey: UTEIRASVYJNKCP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0019	0.037	0.037
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1518	0.3851
Onchocerca volvulus		0.0019	0.037	0.0426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.037	0.1942
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1518	0.3851
Echinococcus granulosus	dna polymerase kappa	0.0042	0.1906	0.1627
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0042	0.1906	0.1906
Entamoeba histolytica	hypothetical protein	0.0042	0.1913	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.037	0.037
Leishmania major	cathepsin L-like protease	0.0019	0.037	0.0939
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.1518	0.1226
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Trypanosoma brucei	unspecified product	0.0042	0.1906	0.4835
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Echinococcus granulosus	dna polymerase eta	0.007	0.3758	0.3543
Brugia malayi	Cathepsin L-like precursor	0.0019	0.037	0.037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.1518	0.7965
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.1518	0.7965
Echinococcus multilocularis	cysteine protease	0.0019	0.037	0.0038
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.037	0.0426
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.1518	0.7934
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.1518	0.7965
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0042	0.1906	0.193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Echinococcus multilocularis	dna polymerase eta	0.007	0.3758	0.3543
Leishmania major	cathepsin L-like protease	0.0073	0.3941	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0333	0.0333
Trypanosoma brucei	unspecified product	0.0029	0.1035	0.2625
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	1	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.1518	0.7934
Entamoeba histolytica	cysteine protease, putative	0.0019	0.037	0.1934
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.3941	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.037	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.037	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Brugia malayi	ImpB/MucB/SamB family protein	0.007	0.3758	0.3758
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.1518	0.1226
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.1518	0.7965
Plasmodium vivax	vivapain-2	0.0019	0.037	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.1765	0.1765
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.1518	0.7965
Brugia malayi	ImpB/MucB/SamB family protein	0.0042	0.1906	0.1906
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Onchocerca volvulus		0.0019	0.037	0.0426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Schistosoma mansoni	alpha-glucosidase	0.014	0.8482	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.1518	0.7904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0042	0.1906	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.037	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.1913	0.1939
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.1906	0.1627
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0143	0.8682	0.8682
Entamoeba histolytica	hypothetical protein	0.0042	0.1913	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Echinococcus multilocularis	cysteine protease	0.0019	0.037	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.7233	0.7233
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.037	0.5
Leishmania major	cathepsin L-like protease	0.0073	0.3941	1
Plasmodium vivax	vivapain-2	0.0019	0.037	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.037	0.1942
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.037	0.0038
Trypanosoma brucei	DNA polymerase eta, putative	0.007	0.3758	0.9535
Leishmania major	cathepsin L-like protease	0.0019	0.037	0.0939
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0042	0.1906	0.996
Echinococcus granulosus	lysosomal alpha glucosidase	0.0163	1	1
Onchocerca volvulus		0.0019	0.037	0.0426
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.037	0.0046
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.037	0.1934
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.1906	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Brugia malayi	Cathepsin L-like precursor	0.0019	0.037	0.037
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0041	0.1822	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.1518	0.7965
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.1913	0.1635
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.1906	0.4835
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.1518	0.1518
Leishmania major	cathepsin L-like protease	0.0073	0.3941	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.8682	0.8682
Leishmania major	DNA polymerase eta, putative	0.007	0.3758	0.9535
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.037	0.037
Brugia malayi	MH2 domain containing protein	0.0122	0.7233	0.7233
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.037	0.1934
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.3521	0.8934
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.037	0.0939
Trypanosoma brucei	unspecified product	0.0029	0.1035	0.2625
Loa Loa (eye worm)	cysteine protease	0.0019	0.037	0.037
Loa Loa (eye worm)	fibroinase	0.0019	0.037	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Giardia lamblia	DINP protein human, muc B family	0.0042	0.1906	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Onchocerca volvulus		0.0019	0.037	0.0426
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.1906	0.5
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0042	0.1906	0.1627
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0333	0.0333
Leishmania major	cathepsin L-like protease	0.0019	0.037	0.0939
Brugia malayi	Cathepsin L-like precursor	0.0019	0.037	0.037
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.1035	0.2625
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.3941	1
Leishmania major	DNA polymerase eta, putative	0.0041	0.1822	0.4624
Onchocerca volvulus	Huntingtin homolog	0.0143	0.8682	1
Onchocerca volvulus		0.0019	0.037	0.0426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.2999	0.2999
Entamoeba histolytica	hypothetical protein	0.0042	0.1913	1
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.1765	0.1765
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.2999	0.2999
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Schistosoma mansoni	hypothetical protein	0.004	0.1765	0.1757
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Brugia malayi	hypothetical protein	0.0042	0.1913	0.1913
Schistosoma mansoni	alpha-glucosidase	0.014	0.8482	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2999	0.2999
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0163	1	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.007	0.3758	0.9535
Trypanosoma cruzi	DNA polymerase eta, putative	0.0041	0.1822	0.4624
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.037	0.0426
Loa Loa (eye worm)	hypothetical protein	0.007	0.3758	0.3758
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.037	0.0038
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.1906	0.5
Brugia malayi	Cathepsin L-like precursor	0.0019	0.037	0.037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0042	0.1906	0.1627
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.1518	0.7965
Onchocerca volvulus		0.0019	0.037	0.0426
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.1518	0.7965
Loa Loa (eye worm)	ctsf protein	0.0019	0.037	0.037
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.037	0.0038
Trypanosoma brucei	glucosidase, putative	0.0036	0.1518	0.3851
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.1035	0.2625
Brugia malayi	Cathepsin L-like precursor	0.0019	0.037	0.037
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0042	0.1906	0.4835
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.037	0.0046
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.1906	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.1518	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0019	0.037	0.037
Onchocerca volvulus		0.0094	0.5404	0.6224
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.037	0.1942
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.1518	0.7965
Leishmania major	cathepsin L-like protease	0.0019	0.037	0.0939
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.037	0.0038
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.2905	0.737
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.037	0.0426
Entamoeba histolytica	hypothetical protein	0.0042	0.1913	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Leishmania major	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.3941	1
Echinococcus granulosus	cathepsin l1	0.0019	0.037	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.3941	1
Brugia malayi	hypothetical protein	0.0143	0.8682	0.8682
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0042	0.1906	0.193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Schistosoma mansoni	hypothetical protein	0.0042	0.1913	0.1939
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.1906	0.4835
Leishmania major	cathepsin L-like protease	0.0019	0.037	0.0939
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.1906	0.4835
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0163	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.037	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0333	0.0333
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.7233	0.7233
Onchocerca volvulus		0.0019	0.037	0.0426
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.1518	0.3851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.1035	0.2625
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Onchocerca volvulus	Huntingtin homolog	0.0143	0.8682	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.037	0.1942
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.1906	0.4835
Schistosoma mansoni	DNA polymerase eta	0.007	0.3758	0.4203
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.1913	0.1635
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.3941	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.037	0.0939
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.2999	0.2999
Schistosoma mansoni	alpha glucosidase	0.0036	0.1518	0.1454
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.037	0.0038
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.1906	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL442899

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 949151