Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dUTP pyrophosphatase | 0.0146 | 0.2998 | 0.1083 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0146 | 0.2998 | 0.1083 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.2998 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0272 | 0.7086 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0272 | 0.7086 | 0.5838 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0272 | 0.7086 | 0.5838 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0146 | 0.2998 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.2842 | 0.0744 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0272 | 0.7086 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0272 | 0.7086 | 0.5838 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0146 | 0.2998 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.2842 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.7086 | 0.5838 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0362 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0314 | 0.8443 | 0.7752 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0314 | 0.8443 | 0.8443 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0272 | 0.7086 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0362 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0165 | 0.3621 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0362 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0146 | 0.2998 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0146 | 0.2998 | 1 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0146 | 0.2998 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.4257 | 0.1799 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0146 | 0.2998 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0314 | 0.8443 | 0.7752 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 1 | 1 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0146 | 0.2998 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0146 | 0.2998 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0272 | 0.7086 | 0.5838 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0146 | 0.2998 | 1 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0146 | 0.2998 | 0.1083 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.7086 | 0.5838 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0146 | 0.2998 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0314 | 0.8443 | 0.8443 |
Echinococcus multilocularis | acetylcholinesterase | 0.0272 | 0.7086 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0146 | 0.2998 | 1 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0146 | 0.2998 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.3076 | 0.3076 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0146 | 0.2998 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0141 | 0.2842 | 0.0744 |
Echinococcus multilocularis | acetylcholinesterase | 0.0272 | 0.7086 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0146 | 0.2998 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0165 | 0.3621 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0272 | 0.7086 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0272 | 0.7086 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 5.2 uM | Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay | ChEMBL. | 18698753 |
IC50 (functional) | = 7.4 uM | Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay | ChEMBL. | 18698753 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18698753 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.