Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0502 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0387 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0248 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cysteine protease | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Plasmodium vivax | unspecified product | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0387 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | cysteine protease | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1791 | 0.1791 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0211 | 0.1183 | 0.1183 |
Echinococcus granulosus | cathepsin l1 | 0.0502 | 0.5946 | 0.5946 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0248 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0751 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0248 | 0.1791 | 0.1791 |
Brugia malayi | follicle stimulating hormone receptor | 0.0211 | 0.1183 | 0.1183 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0139 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0502 | 0.5946 | 0.5946 |
Echinococcus multilocularis | cathepsin L | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0751 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0248 | 0.1791 | 0.1791 |
Trypanosoma cruzi | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0248 | 0.1791 | 0.1791 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0139 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0502 | 0.5946 | 0.5946 |
Brugia malayi | cathepsin L-like precursor | 0.0502 | 0.5946 | 0.5946 |
Onchocerca volvulus | Cathepsin F homolog | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0751 | 1 | 1 |
Giardia lamblia | Encystation-specific protease | 0.0139 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0139 | 0 | 0.5 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0139 | 0 | 0.5 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0751 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0502 | 0.5946 | 0.5946 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0502 | 0.5946 | 0.5946 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0751 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0739 | 0.9804 | 0.9804 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0248 | 0.1791 | 0.1791 |
Echinococcus multilocularis | cysteine protease | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0139 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin B-like cysteine proteinase 3 precursor | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0502 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0387 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0502 | 0.5946 | 0.5946 |
Loa Loa (eye worm) | hypothetical protein | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1791 | 0.1791 |
Toxoplasma gondii | cathepsin CPL | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0502 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0502 | 0.5946 | 0.5946 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Plasmodium vivax | vivapain-1 | 0.0387 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin L precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0751 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0751 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0751 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0139 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0387 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0387 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0248 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Onchocerca volvulus | 0.0751 | 1 | 1 | |
Giardia lamblia | Cysteine protease | 0.0139 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0139 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0751 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0751 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0751 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0751 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0751 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0387 | 0.4054 | 0.4054 |
Schistosoma mansoni | cathepsin s | 0.0248 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0751 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0387 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0751 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.5946 | 0.5946 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED (ADMET) | < 128 mg kg-1 | Dose needed to increase the 100% survival of treated animals (mouse), to twice the number of days | ChEMBL. | 11689078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.