Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0289 | 0.2946 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.026 | 0.2611 | 0.2611 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.0042 | 0.0042 |
Schistosoma mansoni | smad1 5 8 and | 0.0051 | 0.0258 | 0.0321 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0625 | 0.6735 | 0.6735 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0749 | 0.8137 | 0.8137 |
Loa Loa (eye worm) | hypothetical protein | 0.0625 | 0.6735 | 0.6735 |
Schistosoma mansoni | hypothetical protein | 0.0625 | 0.6735 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0749 | 0.8137 | 0.8137 |
Echinococcus multilocularis | tar DNA binding protein | 0.026 | 0.2611 | 0.8845 |
Brugia malayi | MH1 domain containing protein | 0.0051 | 0.0258 | 0.0258 |
Schistosoma mansoni | Smad4 | 0.0051 | 0.0258 | 0.0321 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.2946 | 0.4339 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0051 | 0.0258 | 0.0258 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.0042 | 0.0042 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.0042 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0289 | 0.2946 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0051 | 0.0258 | 0.0321 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.0042 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0289 | 0.2946 | 0.2946 |
Echinococcus multilocularis | GPCR, family 2 | 0.0289 | 0.2946 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0042 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2611 | 0.3838 |
Brugia malayi | RNA recognition motif domain containing protein | 0.026 | 0.2611 | 0.2611 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0289 | 0.2946 | 1 |
Echinococcus multilocularis | smad | 0.0051 | 0.0258 | 0.0741 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0914 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.0042 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0274 | 0.2775 | 0.2775 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2611 | 0.3838 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.0042 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2611 | 0.3838 |
Brugia malayi | Smad1 | 0.0051 | 0.0258 | 0.0258 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0042 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0749 | 0.8137 | 0.8137 |
Brugia malayi | MH2 domain containing protein | 0.0051 | 0.0258 | 0.0258 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0051 | 0.0258 | 0.0741 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0051 | 0.0258 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0051 | 0.0258 | 0.0321 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2611 | 0.3838 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.0042 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.2946 | 0.4339 |
Loa Loa (eye worm) | glutaminase | 0.0274 | 0.2775 | 0.2775 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.2946 | 0.2946 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.2946 | 0.4339 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.0042 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0051 | 0.0258 | 0.0741 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0051 | 0.0258 | 0.0741 |
Brugia malayi | RNA binding protein | 0.026 | 0.2611 | 0.2611 |
Echinococcus multilocularis | Smad4 | 0.0051 | 0.0258 | 0.0741 |
Mycobacterium ulcerans | glutaminase | 0.0274 | 0.2775 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0914 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0289 | 0.2946 | 0.2946 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.0042 | 0.0042 |
Trichomonas vaginalis | glutaminase, putative | 0.0274 | 0.2775 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0051 | 0.0258 | 0.0258 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.0042 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0051 | 0.0258 | 0.0321 |
Loa Loa (eye worm) | TAR-binding protein | 0.026 | 0.2611 | 0.2611 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0289 | 0.2946 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0051 | 0.0258 | 0.0258 |
Brugia malayi | glutaminase DH11.1 | 0.0274 | 0.2775 | 0.2775 |
Brugia malayi | MH1 domain containing protein | 0.0051 | 0.0258 | 0.0258 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0051 | 0.0258 | 0.0741 |
Loa Loa (eye worm) | RNA binding protein | 0.026 | 0.2611 | 0.2611 |
Schistosoma mansoni | glutaminase | 0.0274 | 0.2775 | 0.4084 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.2946 | 0.4339 |
Schistosoma mansoni | smad | 0.0051 | 0.0258 | 0.0321 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0289 | 0.2946 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2611 | 0.3838 |
Echinococcus granulosus | tar DNA binding protein | 0.026 | 0.2611 | 0.8845 |
Echinococcus granulosus | smad | 0.0051 | 0.0258 | 0.0741 |
Brugia malayi | TAR-binding protein | 0.026 | 0.2611 | 0.2611 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.0042 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0051 | 0.0258 | 0.0258 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0289 | 0.2946 | 0.2946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.