Detailed information for compound 949749

Basic information

Technical information
  • TDR Targets ID: 949749
  • Name: 3,11-dimethyl-1H-cyclopenta[b]anthracene-5,10 -dione
  • MW: 274.313 | Formula: C19H14O2
  • H donors: 0 H acceptors: 2 LogP: 3.94 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2ccccc2C(=O)c2c1cc1C(=CCc1c2C)C
  • InChi: 1S/C19H14O2/c1-10-7-8-12-11(2)17-16(9-15(10)12)18(20)13-5-3-4-6-14(13)19(17)21/h3-7,9H,8H2,1-2H3
  • InChiKey: LPEWMUGQLRGDCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,11-dimethyl-1H-cyclopenta[b]anthracene-5,10-quinone
  • 1H-cyclopent[b]anthracene-5,10-dione, 3,11-dimethyl-
  • 3,11-Dimethyl-3a,11a-dihydro-1H-cyclopenta[b]anthracene-5,10-dione
  • InChI=1/C19H14O2/c1-10-7-8-12-11(2)17-16(9-15(10)12)18(20)13-5-3-4-6-14(13)19(17)21/h3-7,9H,8H2,1-2H
  • Sterequinone-A

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Carboxylesterase LipT 0.0105 0.115 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0238 0.0239
Mycobacterium ulcerans carboxylesterase, LipT 0.0105 0.115 1
Trypanosoma brucei pyruvate kinase 1 0.0066 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0599 0.9242
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0719 0.6129
Loa Loa (eye worm) hypothetical protein 0.0033 0.0236 0.0305
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0212 0.0212
Onchocerca volvulus 0.0031 0.0206 0.1251
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0339 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0212 0.0266
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0076 0.0335
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0076 0.0335
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0517 0.0518
Echinococcus multilocularis pyruvate kinase 0.0034 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0339 0.2853
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0206 0.0266
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0319 0.0319
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0212 0.0207
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0041 0.0041
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0046 0.0393 0.0507
Echinococcus granulosus pyruvate kinase 0.0066 0.0647 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0212 0.0266
Giardia lamblia Pyruvate kinase 0.0066 0.0647 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0212 0.0266
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0212 0.0207
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.062 0.7747 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Onchocerca volvulus 0.0105 0.115 0.7461
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0076 0.0952
Echinococcus multilocularis BC026374 protein (S09 family) 0.0105 0.115 0.115
Echinococcus multilocularis para nitrobenzyl esterase 0.0105 0.115 0.115
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0212 0.0266
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0719 0.5995
Brugia malayi nuclear hormone receptor 0.0032 0.0212 0.0266
Echinococcus granulosus para nitrobenzyl esterase 0.0105 0.115 0.1151
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0238 0.3532
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0319 0.4304
Toxoplasma gondii exonuclease III APE 0.004 0.0319 0.48
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0212 0.0212
Brugia malayi nuclear receptor RXR 0.0017 0.0022 0.002
Echinococcus granulosus pyruvate kinase 0.0034 0.0238 0.0239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0489 0.3849
Echinococcus granulosus expressed conserved protein 0.0091 0.097 0.0972
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0517 0.7128
Echinococcus multilocularis tumor protein p63 0.0326 0.3985 0.3985
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0212 0.0266
Loa Loa (eye worm) hypothetical protein 0.0031 0.0206 0.0266
Echinococcus multilocularis pyruvate kinase 0.0066 0.0647 0.0647
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0041 0.0041
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0076 0.009
Loa Loa (eye worm) hypothetical protein 0.0071 0.0719 0.0929
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0041 0.0045
Echinococcus multilocularis expressed conserved protein 0.0091 0.097 0.097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0319 0.48
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0212 0.0266
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0006 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0719 0.5995
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0076 0.0335
Leishmania major cathepsin L-like protease 0.0062 0.0599 0.8286
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0292 0.2439
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0318 0.0402
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0076 0.0076
Onchocerca volvulus 0.0105 0.115 0.7461
Onchocerca volvulus 0.0021 0.0076 0.0395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0483 0.0483
Loa Loa (eye worm) ctsf protein 0.0016 0.0016 0.002
Echinococcus multilocularis protein patched 0.0041 0.0339 0.0339
Leishmania major cathepsin L-like protease 0.0062 0.0599 0.8286
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0517 0.4309
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0022 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0212 0.0266
Echinococcus granulosus chromobox protein 1 0.0067 0.0672 0.0673
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0076 0.0952
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.278 0.2785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0212 0.0274
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0076 0.0098
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.042 0.0414
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Loa Loa (eye worm) RNA binding protein 0.0062 0.0604 0.078
Echinococcus multilocularis GPCR, family 2 0.0015 0.0006 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0329 0.2763
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0212 0.0213
Echinococcus multilocularis pyruvate kinase 0.0034 0.0238 0.0238
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0206 0.0266
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0212 0.0207
Onchocerca volvulus Huntingtin homolog 0.0135 0.1536 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0041 0.0041
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.047 0.0606
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0212 0.1295
Schistosoma mansoni chromobox protein 0.0067 0.0672 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Onchocerca volvulus 0.0105 0.115 0.7461
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.0631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Mycobacterium ulcerans hypothetical protein 0.0071 0.0719 0.5995
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0212 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0483 0.0483
Brugia malayi CHE-14 protein 0.0041 0.0339 0.043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.026 0.026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0006 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.026 0.0255
Echinococcus granulosus cathepsin l1 0.0016 0.0016 0.0016
Echinococcus multilocularis neuroligin 0.0105 0.115 0.115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0232 0.278 0.3589
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0212 0.0207
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0212 0.0213
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0076 0.0335
Brugia malayi hypothetical protein 0.0017 0.0022 0.002
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0041 0.0041
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0319 0.2941
Echinococcus granulosus pyruvate kinase 0.0034 0.0238 0.0239
Echinococcus multilocularis pyruvate kinase 0.0066 0.0647 0.0647
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0483 0.0477
Plasmodium vivax pyruvate kinase, putative 0.0066 0.0647 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0051 0.0459 0.0592
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0319 0.2261
Echinococcus granulosus microtubule associated protein 2 0.0795 0.9984 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0041 0.0053
Brugia malayi Pyruvate kinase, M2 isozyme 0.0066 0.0647 0.0827
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0339 0.0438
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Schistosoma mansoni hypothetical protein 0.004 0.0318 0.0312
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0041 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0212 0.0274
Onchocerca volvulus 0.0021 0.0076 0.0395
Schistosoma mansoni BC026374 protein (S09 family) 0.0105 0.115 0.1146
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0212 0.0207
Echinococcus granulosus pyruvate kinase 0.0066 0.0647 0.0648
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0212 0.0207
Schistosoma mansoni pyruvate kinase 0.0034 0.0238 0.0233
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0339 0.0438
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0076 0.0952
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0212 0.1295
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0319 0.4582
Onchocerca volvulus 0.0047 0.0414 0.2623
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0098
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0647 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0319 0.48
Loa Loa (eye worm) hypothetical protein 0.0031 0.0198 0.0256
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0016 0.0016
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0105 0.115 0.115
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0604 0.0599
Brugia malayi hypothetical protein 0.0017 0.0022 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0212 0.0274
Loa Loa (eye worm) hypothetical protein 0.062 0.7747 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0076 0.0529
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0719 0.5995
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.2375
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0041 0.0023
Onchocerca volvulus Huntingtin homolog 0.0135 0.1536 1
Schistosoma mansoni ap endonuclease 0.004 0.0319 0.0313
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0719 0.0921
Loa Loa (eye worm) carboxylesterase 0.0105 0.115 0.1484
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0604 0.0599
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0393 0.0507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0212 0.0266
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0212 0.0213
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0647 0.4152
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0517 0.0517
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0719 0.5995
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0076 0.0335
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0719 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0319 0.48
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0076 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0483 0.0477
Brugia malayi hypothetical protein 0.0036 0.0268 0.0338
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0076 0.0952
Brugia malayi hypothetical protein 0.0105 0.115 0.1477
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0329 0.2763
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0719 0.0921
Echinococcus granulosus tar DNA binding protein 0.0062 0.0604 0.0605
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0076 0.0335
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.2375
Brugia malayi steroid hormone receptor 0.0032 0.0212 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0212 0.0274
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.2375
Echinococcus granulosus BC026374 protein S09 family 0.0105 0.115 0.1151
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0076 0.0952
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0319 0.1961
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0041 0.0403
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0489 0.7503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0212 0.0266
Onchocerca volvulus 0.0032 0.0212 0.1295
Echinococcus granulosus carboxylesterase 5A 0.062 0.7747 0.776
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Brugia malayi isocitrate dehydrogenase 0.0018 0.0041 0.0045
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1046 0.1342
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0097 0.1046 0.1349
Brugia malayi Carboxylesterase family protein 0.0105 0.115 0.1477
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0604 0.0604
Schistosoma mansoni coup transcription factor 0.0032 0.0212 0.0207
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1577 0.1579
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0076 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0022 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0212 0.0212
Brugia malayi ecdysteroid receptor 0.0032 0.0212 0.0266
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1046 0.1046
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.0631
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0076 0.0335
Echinococcus multilocularis carboxylesterase 5A 0.062 0.7747 0.7747
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0719 0.6834
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0318 0.0318
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0105 0.115 0.1146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Loa Loa (eye worm) hypothetical protein 0.0049 0.0435 0.0561
Onchocerca volvulus 0.003 0.0188 0.1131
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0105 0.115 0.1151
Schistosoma mansoni chromobox protein 0.0067 0.0672 0.0667
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0041 0.0403
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.2375
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0719 0.5995
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Echinococcus multilocularis musashi 0.0031 0.0206 0.0206
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0604 0.0772
Brugia malayi Carboxylesterase family protein 0.0105 0.115 0.1477
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0517 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0292 0.2439
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0212 0.0266
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0319 0.2671
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0339 0.034
Loa Loa (eye worm) carboxylesterase 0.062 0.7747 1
Onchocerca volvulus 0.0105 0.115 0.7461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0041 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0719 1
Plasmodium falciparum pyruvate kinase 0.0066 0.0647 1
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0238 0.3532
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0076 0.0952
Brugia malayi Carboxylesterase family protein 0.0105 0.115 0.1477
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0212 0.0274
Chlamydia trachomatis pyruvate kinase 0.0066 0.0647 1
Onchocerca volvulus 0.0105 0.115 0.7461
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0647 0.5565
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0319 0.252
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0435 0.0553
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0212 0.0207
Schistosoma mansoni ap endonuclease 0.004 0.0319 0.0313
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0022 0.0028
Echinococcus multilocularis acetylcholinesterase 0.062 0.7747 0.7747
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0212 0.0213
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0006 0.0006
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0076 0.0069
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.004 0.032 0.0314
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.026 0.0261
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0319 0.0411
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0212 0.0213
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0319 0.5
Onchocerca volvulus 0.0031 0.0206 0.1251
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0212 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0604 0.0599
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0076 0.0853
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0517 0.0512
Schistosoma mansoni hypothetical protein 0.004 0.032 0.0314
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.0631
Schistosoma mansoni hypothetical protein 0.0035 0.026 0.0255
Schistosoma mansoni lamin 0.0031 0.0206 0.02
Onchocerca volvulus 0.0021 0.0076 0.0395
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0318 0.0402
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0076 0.0098
Onchocerca volvulus 0.0071 0.0719 0.4631
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0105 0.115 0.1146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Loa Loa (eye worm) fibroinase 0.0016 0.0016 0.002
Mycobacterium ulcerans pyruvate kinase 0.0066 0.0647 0.5317
Echinococcus multilocularis cysteine protease 0.0016 0.0016 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0599 0.9242
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3721
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0022 0.002
Echinococcus multilocularis acetylcholinesterase 0.062 0.7747 0.7747
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.053 0.8155
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0008
Brugia malayi Carboxylesterase family protein 0.0105 0.115 0.1477
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0041 0.0403
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0292 0.1819
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0062 0.0072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0329 0.2061
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0212 0.0212
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0212 0.0207
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0339 0.034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0719 0.6129
Schistosoma mansoni pyruvate kinase 0.0066 0.0647 0.0642
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0483 0.0623
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0604 0.0599
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0028
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0672 0.5785
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.0631
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1065 0.1061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3721
Loa Loa (eye worm) hypothetical protein 0.003 0.0188 0.0242
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0212 0.0207
Echinococcus granulosus tumor protein p63 0.0326 0.3985 0.3992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0212 0.0274
Echinococcus granulosus acetylcholinesterase 0.062 0.7747 0.776
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Onchocerca volvulus 0.0048 0.042 0.2657
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0318 0.4785
Schistosoma mansoni hypothetical protein 0.0047 0.0414 0.0409
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0076 0.0853
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0076 0.0853
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0212 0.0213
Echinococcus granulosus lamin 0.0031 0.0206 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0319 0.2671
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0151 0.1192
Echinococcus granulosus intermediate filament protein 0.0031 0.0206 0.0206
Schistosoma mansoni neuroligin 3 (S09 family) 0.0105 0.115 0.1146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0212 0.1295
Brugia malayi hypothetical protein 0.0035 0.026 0.0328
Brugia malayi TAR-binding protein 0.0062 0.0604 0.0772
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0212 0.0213
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0076 0.009
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0647 0.5565
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0016 0.002
Loa Loa (eye worm) oxidoreductase 0.0021 0.0076 0.0098
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0672 0.0867
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.278 0.278
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0318 0.4785
Brugia malayi RNA binding protein 0.0062 0.0604 0.0772
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0274
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0076 0.0529
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0795 0.9984 1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0041 0.0403
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0022 0.0022
Brugia malayi Heterochromatin protein 1 0.0067 0.0672 0.0859
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0719 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0719 0.0929
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0435 0.0561
Loa Loa (eye worm) hypothetical protein 0.0066 0.0647 0.0835
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0393 0.3663
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0647 0.4152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0435 0.0553
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0452 0.3721
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.043 0.656
Echinococcus multilocularis pyruvate kinase 0.0052 0.047 0.047
Brugia malayi nuclear receptor NHR-88 0.0032 0.0212 0.0266
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Loa Loa (eye worm) hypothetical protein 0.0135 0.1536 0.1982
Loa Loa (eye worm) acetylcholinesterase 1 0.062 0.7747 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0076 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0212 0.0266
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0489 0.7503
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0212 0.0266
Schistosoma mansoni gliotactin 0.0105 0.115 0.1146
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0041 0.0361
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0647 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.062 0.7747 0.7759
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0076 0.0952
Brugia malayi Carboxylesterase family protein 0.062 0.7747 1
Schistosoma mansoni hypothetical protein 0.004 0.032 0.0314
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0212 0.0213
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0719 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0076 0.0952
Echinococcus multilocularis chromobox protein 1 0.0067 0.0672 0.0672
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0212 0.0266
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0105 0.115 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0076 0.0572
Schistosoma mansoni hypothetical protein 0.0033 0.0236 0.0231
Schistosoma mansoni intermediate filament proteins 0.0031 0.0206 0.02
Leishmania major cathepsin L-like protease 0.0062 0.0599 0.8286
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0041 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0719 0.0921
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0719 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0483 0.0483
Trypanosoma brucei pyruvate kinase 1, putative 0.0066 0.0647 1
Echinococcus multilocularis microtubule associated protein 2 0.0795 0.9984 0.9984
Echinococcus granulosus lamin dm0 0.0031 0.0206 0.0206
Toxoplasma gondii pyruvate kinase PyK1 0.0066 0.0647 1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0041 0.0403
Brugia malayi hypothetical protein 0.0036 0.0268 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0212 0.0266
Mycobacterium leprae Probable pyruvate kinase PykA 0.0066 0.0647 0.8869
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0076 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0483 0.0483
Echinococcus multilocularis pyruvate kinase 0.0034 0.0238 0.0238
Echinococcus multilocularis lamin dm0 0.0031 0.0206 0.0206
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0212 0.0207
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0016 0.0009
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0318 0.0402
Loa Loa (eye worm) hypothetical protein 0.0038 0.0292 0.0377
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0318 0.4785
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0076 0.0335
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0076 0.009
Brugia malayi intermediate filament protein 0.0031 0.0206 0.0258
Echinococcus granulosus chromobox protein 1 0.0067 0.0672 0.0673
Leishmania major pyruvate kinase 0.0066 0.0647 0.8965
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0076 0.009
Leishmania major pyruvate kinase 0.0066 0.0647 0.8965
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0719 0.6834
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Schistosoma mansoni acetylcholinesterase 0.0105 0.115 0.1146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0212 0.0212
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0212 0.0212
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0105 0.115 0.1146
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0021 0.0019
Loa Loa (eye worm) cysteine protease 0.0016 0.0016 0.002
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1577 0.1577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0212 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0604 0.0599
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0076 0.0583
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0212 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0212 0.0207
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0066 0.0647 0.5473
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Brugia malayi Carboxylesterase family protein 0.062 0.7747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.0631
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0483 0.0615
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Brugia malayi chromobox protein homolog 3 0.0038 0.0292 0.0369
Echinococcus multilocularis lamin 0.0031 0.0206 0.0206
Loa Loa (eye worm) carboxylesterase 0.0105 0.115 0.1484
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0517 0.4112
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Schistosoma mansoni patched 1 0.0041 0.0339 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0483 0.0477
Echinococcus granulosus acetylcholinesterase 0.062 0.7747 0.776
Schistosoma mansoni lamin 0.0031 0.0206 0.02
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1046 0.1047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0599 0.9211
Echinococcus granulosus GPCR family 2 0.0015 0.0006 0.0006
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0076 0.0335
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0238 0.3532
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0022 0.0015
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0647 0.0835
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0212 0.0274
Trichomonas vaginalis spcc417.12 protein, putative 0.0105 0.115 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0076 0.0335
Onchocerca volvulus 0.0025 0.0123 0.0709
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0105 0.115 1
Echinococcus granulosus neuroligin 0.0105 0.115 0.1151
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0647 0.0835
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0016 0.002
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0599 0.9242
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0647 0.4152
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1046 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.1536 0.1982
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0319 0.48
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0319 0.0403
Brugia malayi hypothetical protein 0.0135 0.1536 0.1975
Echinococcus multilocularis cysteine protease 0.0016 0.0016 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Schistosoma mansoni pyruvate kinase 0.0066 0.0647 0.0642
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0719 0.6834
Loa Loa (eye worm) hypothetical protein 0.0071 0.0719 0.0929
Brugia malayi hypothetical protein 0.0232 0.278 0.3583
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0016 0.0016
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0647 0.0835
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0604 0.078
Schistosoma mansoni hypothetical protein 0.004 0.032 0.0314
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0604 0.078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0212 0.0266
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0076 0.0335
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0489 0.4055
Brugia malayi Pyruvate kinase, muscle isozyme 0.0066 0.0647 0.0827
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0212 0.0207
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0672 0.5785
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0206 0.0258
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0028
Echinococcus multilocularis chromobox protein 1 0.0067 0.0672 0.0672
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0006 0.0006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0719 0.5995
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0541
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0414 0.0527
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0517 0.4112
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0076 0.0952
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0599 0.9242
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0319 0.5
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0105 0.115 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0414 0.0409
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0212 0.0213
Echinococcus multilocularis protein dispatched 1 0.0047 0.0414 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0151 0.1192
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0016 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0719 0.5995
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0016 0.0016

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of xanthine oxidase at 50 ug/ml ChEMBL. 16309309

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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