TDR Targets

Basic information

Technical information

TDR Targets ID: 949800
Name: (4S)-4-hydroxy-4-[(3R)-3-hydroxybutyl]-3,5,5- trimethylcyclohex-2-en-1-one
MW: 226.312 | Formula: C13H22O3
H donors: 2 H acceptors: 3 LogP: 0.82 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H](CC[C@@]1(O)C(=CC(=O)CC1(C)C)C)O
InChi: 1S/C13H22O3/c1-9-7-11(15)8-12(3,4)13(9,16)6-5-10(2)14/h7,10,14,16H,5-6,8H2,1-4H3/t10-,13-/m1/s1
InChiKey: CWOFGGNDZOPNFG-ZWNOBZJWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4S)-4-hydroxy-4-[(3R)-3-hydroxybutyl]-3,5,5-trimethyl-cyclohex-2-en-1-one
(4S)-4-hydroxy-4-[(3R)-3-hydroxybutyl]-3,5,5-trimethyl-1-cyclohex-2-enone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine proteinase, putative	0.0703	0.5031	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0703	0.5031	0.4054
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0194	0.5
Giardia lamblia	Cysteine protease	0.0252	0.1643	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0451	0.3139	0.1791
Trypanosoma cruzi	cruzipain precursor, putative	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Giardia lamblia	Hypothetical protein	0.0252	0.1643	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0451	0.3139	0.3139
Toxoplasma gondii	cathepsin CPC1	0.0252	0.1643	0.1477
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1364	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0703	0.5031	0.4932
Schistosoma mansoni	cathepsin F (C01 family)	0.0913	0.6612	0.6612
Trypanosoma cruzi	cysteine proteinase, putative	0.0703	0.5031	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0913	0.6612	0.5946
Brugia malayi	Cathepsin L-like precursor	0.1364	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0252	0.1643	0.1643
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0252	0.1643	0.1643
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Leishmania major	cathepsin L-like protease	0.1364	1	1
Giardia lamblia	Cathepsin L precursor	0.0252	0.1643	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0703	0.5031	0.4054
Onchocerca volvulus		0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0913	0.6612	0.5946
Giardia lamblia	Cysteine protease	0.0252	0.1643	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Onchocerca volvulus		0.1364	1	1
Onchocerca volvulus	Cathepsin F homolog	0.1364	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1364	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0913	0.6612	0.6612
Entamoeba histolytica	cysteine proteinase 1, putative	0.0703	0.5031	0.4054
Plasmodium vivax	vivapain-1	0.0703	0.5031	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Brugia malayi	Cathepsin L-like precursor	0.0913	0.6612	0.6612
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Echinococcus multilocularis	cysteine protease	0.1364	1	1
Brugia malayi	Muscleblind-like protein	0.0145	0.0841	0.0841
Onchocerca volvulus		0.1364	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1364	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1364	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0252	0.1643	0.1643
Brugia malayi	cathepsin L precursor	0.0252	0.1643	0.1643
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Plasmodium vivax	vivapain-3	0.0703	0.5031	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Schistosoma mansoni	cathepsin F (C01 family)	0.1364	1	1
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0252	0.1643	0.1643
Brugia malayi	Cathepsin L-like precursor	0.0451	0.3139	0.3139
Brugia malayi	Papain family cysteine protease containing protein	0.0703	0.5031	0.5031
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Giardia lamblia	Cathepsin L-like protease	0.0252	0.1643	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Brugia malayi	Cathepsin L-like precursor	0.1364	1	1
Brugia malayi	Cathepsin L-like precursor	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0703	0.5031	0.5031
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Entamoeba histolytica	cysteine proteinase, putative	0.1364	1	1
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0252	0.1643	0.1643
Entamoeba histolytica	cysteine proteinase, putative	0.0913	0.6612	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.0703	0.5031	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Echinococcus multilocularis	cathepsin L	0.0703	0.5031	0.4932
Brugia malayi	cathepsin F-like cysteine proteinase	0.0451	0.3139	0.3139
Onchocerca volvulus	Cathepsin L homolog	0.1364	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0252	0.1643	0.1643
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0252	0.1643	0.1643
Entamoeba histolytica	cysteine protease, putative	0.1364	1	1
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.0841	0.066
Entamoeba histolytica	cysteine proteinase, putative	0.0703	0.5031	0.4054
Toxoplasma gondii	cathepsin CPC2	0.0252	0.1643	0.1477
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0703	0.5031	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0841	0.0841
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0451	0.3139	0.3139
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0115	0.0115
Loa Loa (eye worm)	cathepsin B	0.0252	0.1643	0.1643
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0252	0.1643	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0451	0.3139	0.1791
Giardia lamblia	Cathepsin L precursor	0.0252	0.1643	0.5
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0252	0.1643	0.1643
Echinococcus granulosus	cathepsin b	0.0252	0.1643	0.1477
Toxoplasma gondii	cathepsin B	0.0252	0.1643	0.1477
Brugia malayi	Papain family cysteine protease containing protein	0.0252	0.1643	0.1643
Echinococcus granulosus	cathepsin L	0.0703	0.5031	0.4932
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Echinococcus granulosus	cathepsin l1	0.1364	1	1
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1364	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1364	1	1
Plasmodium vivax	vivapain-2	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0252	0.1643	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0194	0.5
Echinococcus multilocularis	cathepsin L	0.0252	0.1643	0.1477
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1364	1	1
Echinococcus granulosus	muscleblind protein	0.0145	0.0841	0.066
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0252	0.1643	0.1477
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0194	0.0194
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0252	0.1643	0.1643
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Leishmania major	cathepsin L-like protease	0.1364	1	1
Plasmodium vivax	unspecified product	0.0703	0.5031	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.1364	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0703	0.5031	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.1364	1	1
Giardia lamblia	Cysteine protease	0.0252	0.1643	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0703	0.5031	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Brugia malayi	cathepsin B-like cysteine proteinase	0.0252	0.1643	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0913	0.6612	0.6612
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Onchocerca volvulus		0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Brugia malayi	Cathepsin L-like precursor	0.1364	1	1
Onchocerca volvulus		0.1364	1	1
Echinococcus multilocularis	cathepsin b	0.0252	0.1643	0.1477
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Brugia malayi	Cathepsin L-like precursor	0.1364	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0703	0.5031	0.5031
Trypanosoma cruzi	cysteine peptidase, putative	0.1364	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Echinococcus granulosus	cathepsin l1	0.0913	0.6612	0.6545
Entamoeba histolytica	cysteine proteinase 2	0.0703	0.5031	0.4054
Giardia lamblia	Cathepsin L precursor	0.0252	0.1643	0.5
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Giardia lamblia	Cathepsin L precursor	0.0252	0.1643	0.5
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.1364	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0252	0.1643	0.1643
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0252	0.1643	0.1643
Leishmania major	cathepsin L-like protease	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0451	0.3139	0.3139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Loa Loa (eye worm)	cysteine protease	0.1364	1	1
Plasmodium vivax	unspecified product	0.0451	0.3139	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0913	0.6612	0.6612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Leishmania major	cathepsin L-like protease	0.1364	1	1
Giardia lamblia	Cathepsin L precursor	0.0252	0.1643	0.5
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0703	0.5031	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0252	0.1643	0.1643
Echinococcus multilocularis	cysteine protease	0.1364	1	1
Giardia lamblia	Cathepsin L precursor	0.0252	0.1643	0.5
Leishmania major	cysteine peptidase A (CPA)	0.1364	1	1
Onchocerca volvulus		0.1364	1	1
Echinococcus granulosus	cysteine protease	0.0703	0.5031	0.4932
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0703	0.5031	0.5031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0252	0.1643	0.1643
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0703	0.5031	0.4054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0115	0.0115
Echinococcus multilocularis	cathepsin b	0.0252	0.1643	0.1477
Giardia lamblia	Hypothetical protein	0.0252	0.1643	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1364	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Giardia lamblia	Cathepsin L-like protease	0.0252	0.1643	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0194	0.0194
Onchocerca volvulus	Cathepsin L homolog	0.1364	1	1
Echinococcus multilocularis	muscleblind protein	0.0145	0.0841	0.066
Brugia malayi	Papain family cysteine protease containing protein	0.0252	0.1643	0.1643
Entamoeba histolytica	cysteine proteinase, putative	0.0703	0.5031	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0913	0.6612	0.6612
Leishmania major	cathepsin L-like protease	0.1364	1	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0194	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.1364	1	1
Plasmodium vivax	vivapain-2	0.1364	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0115	0.0115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0451	0.3139	0.3139
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0252	0.1643	0.1643
Schistosoma mansoni	cathepsin C	0.0252	0.1643	0.1643
Schistosoma mansoni	cathepsin s	0.0451	0.3139	0.3139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Brugia malayi	Papain family cysteine protease containing protein	0.0703	0.5031	0.5031
Schistosoma mansoni	cathepsin F (C01 family)	0.1364	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0252	0.1643	0.1643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0703	0.5031	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Echinococcus granulosus	cathepsin b	0.0252	0.1643	0.1477
Brugia malayi	Cathepsin L-like precursor	0.0913	0.6612	0.6612
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Onchocerca volvulus		0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	ctsf protein	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Toxoplasma gondii	cathepsin CPL	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0194	0.5
Leishmania major	cathepsin L-like protease	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Entamoeba histolytica	cysteine protease, putative	0.0703	0.5031	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0451	0.3139	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0115	0.0115
Giardia lamblia	Encystation-specific protease	0.0252	0.1643	0.5
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0841	0.0841
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0913	0.6612	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1364	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1364	1	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1643	0.1643
Onchocerca volvulus		0.0913	0.6612	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Loa Loa (eye worm)	fibroinase	0.1364	1	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0252	0.1643	0.1477
Brugia malayi	fibroinase precursor	0.0252	0.1643	0.1643
Giardia lamblia	Cathepsin B precursor	0.0252	0.1643	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0252	0.1643	0.1643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1364	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1364	1	1
Giardia lamblia	Cysteine protease	0.0252	0.1643	0.5
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0252	0.1643	0.5
Leishmania major	cathepsin L-like protease	0.1364	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0252	0.1643	0.5
Leishmania major	cathepsin L-like protease	0.1364	1	1
Brugia malayi	cathepsin L-like precursor	0.0913	0.6612	0.6612
Echinococcus granulosus	cathepsin L	0.0252	0.1643	0.1477
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0703	0.5031	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0252	0.1643	0.1643

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of COX2 in mouse lung fibroblast assessed as PGE2 production by radioimmunoassay	ChEMBL.	15974621

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL444659

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 949800