TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 596.701 | Formula: C28H36N8O5S
H donors: 1 H acceptors: 6 LogP: 1.24 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: COC[C@H](Oc1ncc(cc1c1nc2c(CC)n(nc2c(=O)[nH]1)Cc1ccccn1)S(=O)(=O)N1CCN(CC1)CC)C
InChi: 1S/C28H36N8O5S/c1-5-23-24-25(33-36(23)17-20-9-7-8-10-29-20)27(37)32-26(31-24)22-15-21(16-30-28(22)41-19(3)18-40-4)42(38,39)35-13-11-34(6-2)12-14-35/h7-10,15-16,19H,5-6,11-14,17-18H2,1-4H3,(H,31,32,37)/t19-/m1/s1
InChiKey: AXJKWRLSLUKVML-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References
Canis lupus familiaris	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	781 aa	24.6 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	780 aa	23.7 %
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	803 aa	22.9 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	717 aa	25.9 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	735 aa	23.7 %
Drosophila melanogaster	Phosphodiesterase 6	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	794 aa	32.8 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	824 aa	24.9 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	760 aa	22.9 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	776 aa	25.3 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	849 aa	30.3 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	781 aa	24.7 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	784 aa	23.6 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	776 aa	25.5 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	824 aa	24.9 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	803 aa	22.9 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	789 aa	24.3 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	727 aa	24.1 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	712 aa	26.1 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	741 aa	22.3 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	778 aa	25.1 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	710 aa	25.9 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	733 aa	21.3 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	784 aa	23.5 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	846 aa	30.7 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	781 aa	24.7 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	823 aa	29.5 %
Trichomonas vaginalis	conserved hypothetical protein	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	711 aa	19.7 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	776 aa	25.4 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	861 aa	748 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.1197	0.2442
Echinococcus granulosus	protein jagged 1	0.0101	0.2986	0.2986
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0404	0.0445
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0041	0.099	0.109
Loa Loa (eye worm)	animal heme peroxidase	0.0312	1	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0018	0.024	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Brugia malayi	Calcium binding EGF domain containing protein	0.0101	0.2986	0.2986
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0179	0.0179
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0018	0.024	0.0107
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0041	0.099	0.099
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Toxoplasma gondii	EGF family domain-containing protein	0.0101	0.2986	0.4943
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Leishmania major	glyoxalase I,trypanothione-dependent glyoxalase I	0.0187	0.5857	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0101	0.2986	0.2986
Trypanosoma cruzi	aldo/keto reductase, putative	0.0018	0.0243	0.0338
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0018	0.0243	0.0243
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0041	0.099	0.099
Onchocerca volvulus		0.0016	0.0179	0.0179
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1116	0.1116
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0246	0.0021
Plasmodium falciparum	glyoxalase I	0.0043	0.1077	0.1581
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0018	0.024	0.0332
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0264
Loa Loa (eye worm)	cysteine protease	0.0016	0.0179	0.0179
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0018	0.024	0.0332
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0179	0.0179
Schistosoma mansoni	gynecophoral canal protein	0.0043	0.1077	0.1077
Plasmodium vivax	glyoxalase I, putative	0.0187	0.5857	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0041	0.099	0.2564
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0012	0.0046	0.0051
Brugia malayi	Cadherin domain containing protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Trypanosoma brucei	aldo/keto reductase, putative	0.0018	0.0243	0.001
Mycobacterium ulcerans	glyoxalase GloA	0.0043	0.1077	0.2143
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Onchocerca volvulus		0.0016	0.0179	0.0179
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Brugia malayi	notch-like transmembrane receptor	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Schistosoma mansoni	laminin gamma-3 chain	0.0101	0.2986	0.2986
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0018	0.024	0.0264
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0187	0.5857	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0047	0.1197	0.1794
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0179	0.0133
Echinococcus granulosus	aldo keto reductase	0.0041	0.099	0.099
Leishmania major	cathepsin L-like protease	0.0062	0.17	0.2846
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.024	0.0264
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0017	0.021	0.021
Schistosoma mansoni	acetylcholinesterase	0.0024	0.044	0.044
Onchocerca volvulus	Slit protein homolog	0.0101	0.2986	0.2986
Schistosoma mansoni	septate junction protein	0.0101	0.2986	0.2986
Leishmania major	cathepsin L-like protease	0.0016	0.0179	0.0228
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1077	0.2204
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.17	0.2846
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0106	0.3166	0.3485
Loa Loa (eye worm)	oxidoreductase	0.0041	0.099	0.099
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.3166	0.537
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0018	0.024	0.024
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0065	0.1799	0.1761
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.17	0.2846
Schistosoma mansoni	notch	0.0101	0.2986	0.2986
Trichomonas vaginalis	aldo-keto reductase, putative	0.0018	0.0243	0.0267
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0264
Trichomonas vaginalis	guanylate cyclase, putative	0.0012	0.0046	0.0051
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0018	0.024	0.024
Echinococcus granulosus	neurogenic locus notch protein 4	0.0101	0.2986	0.2986
Trichomonas vaginalis	aldo/keto reductase, putative	0.0041	0.099	0.109
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.024	0.0332
Toxoplasma gondii	GAF domain-containing protein	0.0047	0.1197	0.1794
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0018	0.024	0.0194
Echinococcus multilocularis	protein jagged 1	0.0101	0.2986	0.2953
Brugia malayi	Cadherin domain containing protein	0.0101	0.2986	0.2986
Onchocerca volvulus		0.0101	0.2986	0.2986
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0179	0.0179
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0018	0.024	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1077	0.2143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0404	0.0479
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0018	0.0243	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.2565	0.2823
Toxoplasma gondii	glyoxalase I, putative	0.0187	0.5857	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Echinococcus multilocularis	para nitrobenzyl esterase	0.0024	0.044	0.0395
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.1077	0.245
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0246	0.027
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0018	0.024	0.0332
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0404	0.0445
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0246	0.02
Toxoplasma gondii	glyoxalase family protein	0.0043	0.1077	0.1581
Trichomonas vaginalis	aldo-keto reductase, putative	0.0018	0.0243	0.0267
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0041	0.099	0.1624
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0179	0.0133
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0404	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0179	0.0133
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Trypanosoma brucei	prostaglandin f synthase	0.0041	0.099	0.2564
Onchocerca volvulus		0.0101	0.2986	0.2986
Loa Loa (eye worm)	oxidoreductase	0.0041	0.099	0.099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1116	0.1116
Onchocerca volvulus		0.0101	0.2986	0.2986
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.1197	0.2442
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0404	0.0404
Loa Loa (eye worm)	oxidoreductase	0.0041	0.099	0.099
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0246	0.0117
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0041	0.099	0.109
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Leishmania major	hypothetical protein, conserved	0.0018	0.024	0.0332
Echinococcus multilocularis	aldo keto reductase	0.0041	0.099	0.0948
Brugia malayi	Animal haem peroxidase family protein	0.0312	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0024	0.044	0.0395
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Echinococcus granulosus	delta-like protein 1	0.0101	0.2986	0.2986
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0065	0.1799	0.1799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Schistosoma mansoni	aldo-keto reductase	0.0041	0.099	0.099
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.9085	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.1799	0.198
Loa Loa (eye worm)	carboxylesterase	0.0143	0.4386	0.4386
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.3166	0.3485
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1116	0.1116
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.1197	0.1794
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0179	0.0179
Brugia malayi	Carboxylesterase family protein	0.0024	0.044	0.044
Echinococcus granulosus	neuroligin	0.0024	0.044	0.044
Onchocerca volvulus	Lactoylglutathione lyase homolog	0.0187	0.5857	0.5857
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0018	0.024	0.024
Plasmodium vivax	aldehyde reductase, putative	0.0018	0.0243	0.0112
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0041	0.099	0.099
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0179	0.0179
Echinococcus multilocularis	protein jagged 1	0.0101	0.2986	0.2953
Entamoeba histolytica	aldose reductase, putative	0.0041	0.099	0.109
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0018	0.024	0.024
Mycobacterium ulcerans	oxidoreductase	0.0041	0.099	0.1929
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0246	0.027
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0059	0.1607	0.1769
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	0.0043	0.1077	0.1077
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0246	0.0007
Onchocerca volvulus		0.0023	0.0404	0.0404
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Toxoplasma gondii	hypothetical protein	0.0047	0.1197	0.1794
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.021	0.0055
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0801	0.0759
Brugia malayi	Carboxylesterase family protein	0.0024	0.044	0.044
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0065	0.1799	0.1799
Brugia malayi	Delta serrate ligand family protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	neurogenic locus protein delta	0.0101	0.2986	0.2953
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0065	0.1799	0.1799
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Entamoeba histolytica	hypothetical protein	0.0035	0.0801	0.0881
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0246	0.0343
Trypanosoma cruzi	aldo/keto reductase, putative	0.0041	0.099	0.1624
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0101	0.2986	0.2953
Schistosoma mansoni	slit	0.0101	0.2986	0.2986
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Echinococcus multilocularis	acetylcholinesterase	0.0143	0.4386	0.4359
Echinococcus granulosus	protein jagged 1	0.0101	0.2986	0.2986
Schistosoma mansoni	BC026374 protein (S09 family)	0.0024	0.044	0.044
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0404	0.0552
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0012	0.0046	0.0046
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1116	0.1116
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.4253	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.17	0.2846
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0106	0.3166	0.3166
Brugia malayi	Animal haem peroxidase family protein	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Brugia malayi	Animal haem peroxidase family protein	0.0312	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0018	0.024	0.024
Schistosoma mansoni	notch	0.0101	0.2986	0.2986
Brugia malayi	Animal haem peroxidase family protein	0.0312	1	1
Plasmodium vivax	glyoxalase I, putative	0.0043	0.1077	0.1581
Schistosoma mansoni	aldo-keto reductase	0.0041	0.099	0.099
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1116	0.1075
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1077	0.2143
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0404	0.0445
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0404	0.0616
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.1258	0.2086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Brugia malayi	hypoxia-induced factor 1	0.0146	0.4504	0.4504
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	0.0043	0.1077	0.1077
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0012	0.0046	0.0051
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0018	0.024	0.024
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Brugia malayi	Calcium binding EGF domain containing protein	0.0101	0.2986	0.2986
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0404	0.0404
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0404	0.0479
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0018	0.024	0.0194
Schistosoma mansoni	notch	0.0101	0.2986	0.2986
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0404	0.0479
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Onchocerca volvulus		0.0016	0.0179	0.0179
Echinococcus granulosus	peroxidasin	0.0312	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0179	0.0197
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0041	0.099	0.2243
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0059	0.1607	0.1769
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0246	0.0246
Onchocerca volvulus	Peroxidasin homolog	0.0312	1	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0101	0.2986	0.2953
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0179	0.0179
Loa Loa (eye worm)	fibroinase	0.0016	0.0179	0.0179
Loa Loa (eye worm)	carboxylesterase	0.0024	0.044	0.044
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0404	0.085
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.0385	0.0805
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.024	0.0264
Entamoeba histolytica	hypothetical protein	0.0035	0.0801	0.0881
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0018	0.024	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0046	0.0051
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.024	0.0332
Mycobacterium ulcerans	glyoxalase GloA	0.0043	0.1077	0.2143
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.021	1
Echinococcus multilocularis	cysteine protease	0.0016	0.0179	0.0133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0018	0.0243	0.0267
Echinococcus granulosus	neurogenic locus notch protein	0.0101	0.2986	0.2986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Entamoeba histolytica	aldose reductase, putative	0.0041	0.099	0.109
Echinococcus multilocularis	slit 2 protein	0.0101	0.2986	0.2953
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0018	0.024	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Schistosoma mansoni	hypothetical protein	0.0035	0.0801	0.0801
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0246	0.0343
Plasmodium falciparum	aldehyde reductase, putative	0.0018	0.0243	0.0112
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0018	0.0243	0.0197
Brugia malayi	Peroxidasin	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.024	0.024
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0246	0.0246
Brugia malayi	lactoylglutathione lyase	0.0187	0.5857	0.5857
Brugia malayi	NADH-dependent xylose reductase	0.0018	0.0243	0.0243
Trypanosoma cruzi	aldo-keto reductase	0.0041	0.099	0.1624
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Onchocerca volvulus		0.0035	0.0801	0.0801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0046	0.0051
Echinococcus multilocularis	peroxidasin	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0046	0.0046
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0024	0.044	0.064
Plasmodium falciparum	glyoxalase I	0.0187	0.5857	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0179	0.0133
Echinococcus multilocularis	aldo keto reductase	0.0041	0.099	0.0948
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1116	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0018	0.024	0.024
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0018	0.024	0.024
Trichomonas vaginalis	adenylate cyclase, putative	0.0012	0.0046	0.0051
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0246	0.027
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Toxoplasma gondii	aldose reductase, putative	0.0041	0.099	0.1428
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0018	0.024	0.0264
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0187	0.5857	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.9085	1
Echinococcus multilocularis	cysteine protease	0.0016	0.0179	0.0133
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0404	0.0616
Onchocerca volvulus	Putative protein	0.0043	0.1077	0.1077
Onchocerca volvulus	Peroxidase homolog	0.0312	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0801	0.0801
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0179	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0243	0.0267
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Echinococcus granulosus	aldo keto reductase	0.0041	0.099	0.099
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Echinococcus granulosus	aryl hydrocarbon receptor	0.0012	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0017	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Echinococcus granulosus	hypothetical protein	0.0041	0.099	0.099
Echinococcus multilocularis	protein jagged 2	0.0101	0.2986	0.2953
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0018	0.024	0.0194
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.1521	0.2538
Onchocerca volvulus		0.0024	0.044	0.044
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0179	0.0197
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Brugia malayi	Carboxylesterase family protein	0.0024	0.044	0.044
Onchocerca volvulus		0.0016	0.0179	0.0179
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0018	0.0243	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Echinococcus granulosus	slit 2 protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	notch protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	aldehyde reductase	0.0022	0.0385	0.034
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0404	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1197	0.1197
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0179	0.0179
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0179	0.0179
Onchocerca volvulus	Neurogenic locus notch homolog	0.0101	0.2986	0.2986
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0246	0.0087
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0041	0.099	0.099
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.024	0.0332
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.1197	0.1318
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0012	0.0046	0.0051
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0047	0.1197	0.25
Schistosoma mansoni	ap endonuclease	0.0018	0.0246	0.0246
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Leishmania major	cathepsin L-like protease	0.0062	0.17	0.2846
Onchocerca volvulus		0.0016	0.0179	0.0179
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0059	0.1607	0.2685
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0024	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Trichomonas vaginalis	aldo/keto reductase, putative	0.0041	0.099	0.109
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0012	0.0046	0.0051
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Echinococcus granulosus	neurogenic locus protein delta	0.0101	0.2986	0.2986
Onchocerca volvulus	Dual oxidase homolog	0.0312	1	1
Leishmania major	cathepsin L-like protease	0.0016	0.0179	0.0228
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0801	0.0881
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.024	0.0332
Echinococcus granulosus	acetylcholinesterase	0.0143	0.4386	0.4386
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.17	0.2846
Loa Loa (eye worm)	hypothetical protein	0.0017	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.044	0.044
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0018	0.0243	0.0267
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0106	0.3166	0.3485
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0179	0.0197
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.044	0.044
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Onchocerca volvulus		0.0312	1	1
Onchocerca volvulus		0.0312	1	1
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0018	0.024	0.0332
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0179	0.0228
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0404	0.0479
Schistosoma mansoni	notch	0.0101	0.2986	0.2986
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0106	0.3166	0.3135
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Schistosoma mansoni	ap endonuclease	0.0018	0.0246	0.0246
Brugia malayi	hypothetical protein	0.0159	0.4913	0.4913
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.024	0.0332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.024	0.0332
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0404	0.0479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Onchocerca volvulus		0.0041	0.099	0.099
Toxoplasma gondii	aldo-keto reductase	0.0018	0.0243	0.0112
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Echinococcus granulosus	voltage gated potassium channel subunit	0.0018	0.0243	0.0243
Echinococcus multilocularis	acetylcholinesterase	0.0143	0.4386	0.4359
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0404	0.0404
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Trichomonas vaginalis	guanylate cyclase, putative	0.0012	0.0046	0.0051
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0043	0.1077	0.2204
Giardia lamblia	Aldose reductase	0.0041	0.099	0.0848
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.3166	0.537
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0012	0.0046	0.0051
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0246	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0107
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Brugia malayi	Animal haem peroxidase family protein	0.0312	1	1
Echinococcus granulosus	notch	0.0101	0.2986	0.2986
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0018	0.024	0.0264
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0065	0.1799	0.1799
Plasmodium vivax	phosphodiesterase gamma, putative	0.0018	0.024	0.0107
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.021	0.0055
Loa Loa (eye worm)	PDE1B protein	0.0018	0.024	0.024
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Echinococcus granulosus	cathepsin l1	0.0016	0.0179	0.0179
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0246	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0143	0.4386	0.4386
Mycobacterium tuberculosis	Probable oxidoreductase	0.0041	0.099	0.199
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.4253	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Echinococcus multilocularis	aldo keto reductase	0.0041	0.099	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Schistosoma mansoni	pol-related	0.0041	0.099	0.099
Onchocerca volvulus		0.0024	0.044	0.044
Trichomonas vaginalis	spcc417.12 protein, putative	0.0024	0.044	0.0484
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0018	0.024	0.0107
Echinococcus granulosus	single minded 2	0.0035	0.0801	0.0801
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0404	0.0479
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0243	0.008
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Onchocerca volvulus	Peroxidase homolog	0.0312	1	1
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0018	0.024	0.024
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0106	0.3166	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0179	0.0179
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Echinococcus multilocularis	neuroligin	0.0024	0.044	0.0395
Mycobacterium tuberculosis	Conserved protein TB27.3	0.0043	0.1077	0.2204
Echinococcus multilocularis	carboxylesterase 5A	0.0143	0.4386	0.4359
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0018	0.024	0.024
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0801	0.0758
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Mycobacterium tuberculosis	Conserved protein	0.0018	0.0243	0.0156
Loa Loa (eye worm)	oxidoreductase	0.0041	0.099	0.099
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0018	0.024	0.0264
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0801	0.0801
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0046	0.0051
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0065	0.1799	0.198
Brugia malayi	Carboxylesterase family protein	0.0024	0.044	0.044
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0404	0.0552
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Leishmania major	cathepsin L-like protease	0.0016	0.0179	0.0228
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1077	0.1185
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0101	0.2986	0.2953
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1077	0.2143
Onchocerca volvulus		0.0024	0.044	0.044
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0179	0.0179
Giardia lamblia	Aldose reductase	0.0041	0.099	0.0848
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0041	0.099	0.0948
Echinococcus granulosus	acetylcholinesterase	0.0143	0.4386	0.4386
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Loa Loa (eye worm)	animal heme peroxidase	0.0312	1	1
Plasmodium falciparum	phosphodiesterase delta, putative	0.0018	0.024	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Loa Loa (eye worm)	carboxylesterase	0.0024	0.044	0.044
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0107
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.4253	1
Mycobacterium ulcerans	biphenyl-2,3-diol 1,2-dioxygenase	0.0043	0.1077	0.2143
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0018	0.0243	0.0243
Schistosoma mansoni	notch	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0187	0.5857	0.5857
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.2565	0.2823
Trichomonas vaginalis	aldo-keto reductase, putative	0.0018	0.0243	0.0267
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0018	0.024	0.024
Brugia malayi	GCC2 and GCC3 family protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0017	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1116	0.1116
Mycobacterium ulcerans	carboxylesterase, LipT	0.0024	0.044	0.0568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Onchocerca volvulus		0.0012	0.0046	0.0046
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0024	0.044	0.044
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0179	0.0179
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0404	0.085
Echinococcus granulosus	neural cadherin	0.0101	0.2986	0.2986
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0404	0.0404
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0179	0.0179
Onchocerca volvulus	Chorion peroxidase homolog	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4386	0.4386
Echinococcus granulosus	protein jagged 2	0.0101	0.2986	0.2986
Onchocerca volvulus		0.0018	0.0243	0.0243
Loa Loa (eye worm)	blistered cuticle protein 3	0.0312	1	1
Echinococcus granulosus	fibropellin Ia	0.0101	0.2986	0.2986
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.9085	1
Brugia malayi	Muscle positioning protein 4	0.0101	0.2986	0.2986
Onchocerca volvulus		0.0312	1	1
Brugia malayi	Carboxylesterase family protein	0.0143	0.4386	0.4386
Onchocerca volvulus	Putative cubilin	0.0101	0.2986	0.2986
Loa Loa (eye worm)	animal heme peroxidase	0.0312	1	1
Brugia malayi	hypothetical protein	0.0035	0.0801	0.0801
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0018	0.024	0.024
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1077	0.2143
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Schistosoma mansoni	peroxidasin	0.0312	1	1
Onchocerca volvulus		0.0041	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0018	0.024	0.024
Onchocerca volvulus		0.0101	0.2986	0.2986
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0018	0.024	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0018	0.024	0.024
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.0801	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0017	0.021	0.021
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0107
Brugia malayi	hypothetical protein	0.0024	0.044	0.044
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.2565	0.2823
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0246	0.0117
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.3497	0.3497
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1116	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0159	0.4913	0.4913
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.3497	0.3497
Schistosoma mansoni	cell polarity protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0012	0.0046	0.0046
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0024	0.044	0.044
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0264
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Echinococcus granulosus	carboxylesterase 5A	0.0143	0.4386	0.4386
Entamoeba histolytica	hypothetical protein	0.0035	0.0801	0.0881
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0041	0.099	0.099
Loa Loa (eye worm)	Notch2	0.0101	0.2986	0.2986
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Echinococcus granulosus	aldo keto reductase	0.0041	0.099	0.099
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0047	0.1197	0.25
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.024	0.0107
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0018	0.024	0.0194
Echinococcus granulosus	neurogenic locus notch protein	0.0101	0.2986	0.2986
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1799	0.1799
Echinococcus granulosus	protein jagged 2	0.0101	0.2986	0.2986
Brugia malayi	Blistered cuticle protein 3	0.0312	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0404	0.0616
Leishmania major	hypothetical protein, conserved	0.0018	0.024	0.0332
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0106	0.3166	0.3166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1077	0.2204
Echinococcus multilocularis	notch	0.0101	0.2986	0.2953
Mycobacterium tuberculosis	Cadmium inducible protein CadI	0.0043	0.1077	0.2204
Echinococcus multilocularis	neurogenic locus notch protein	0.0101	0.2986	0.2953
Onchocerca volvulus		0.0041	0.099	0.099
Trichomonas vaginalis	aldo-keto reductase, putative	0.0041	0.099	0.109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0018	0.024	0.024
Schistosoma mansoni	gliotactin	0.0024	0.044	0.044
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Leishmania major	aldo-keto reductase-like protein	0.0041	0.099	0.1624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0246	0.0163
Onchocerca volvulus		0.0016	0.0179	0.0179
Schistosoma mansoni	4-hydroxyphenylpyruvate dioxygenase	0.0043	0.1077	0.1077
Onchocerca volvulus		0.0024	0.044	0.044
Echinococcus granulosus	aldehyde reductase	0.0022	0.0385	0.0385
Loa Loa (eye worm)	animal heme peroxidase	0.0312	1	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0179	0.0197
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0106	0.3166	1
Onchocerca volvulus		0.0041	0.099	0.099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.17	0.4989
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0179	0.0228
Echinococcus multilocularis	neural cadherin	0.0101	0.2986	0.2953
Leishmania major	cathepsin L-like protease	0.0016	0.0179	0.0228
Onchocerca volvulus		0.0016	0.0179	0.0179
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0404	0.0404
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0018	0.024	0.0194
Onchocerca volvulus		0.0041	0.099	0.099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1116	0.1116
Echinococcus granulosus	para nitrobenzyl esterase	0.0024	0.044	0.044
Onchocerca volvulus		0.0024	0.044	0.044
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Schistosoma mansoni	peroxidasin	0.0312	1	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0024	0.044	0.064
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0179	0.0179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0179	0.0197
Mycobacterium leprae	conserved hypothetical protein	0.0047	0.1197	0.2736
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1077	0.2143
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Schistosoma mansoni	notch	0.0101	0.2986	0.2986
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.9085	1
Leishmania major	cathepsin L-like protease	0.0016	0.0179	0.0228
Brugia malayi	Calcium binding EGF domain containing protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Mycobacterium leprae	Possible oxidoreductase	0.0018	0.0243	0.0467
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0041	0.099	0.1624
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Brugia malayi	MH2 domain containing protein	0.0116	0.3497	0.3497
Brugia malayi	Carboxylesterase family protein	0.0143	0.4386	0.4386
Schistosoma mansoni	potassium channel beta	0.0018	0.0243	0.0243
Plasmodium falciparum	aldo-keto reductase, putative	0.0018	0.0243	0.0112
Giardia lamblia	High cysteine protein	0.0101	0.2986	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2986	0.2986
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0018	0.0243	0.0267
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0801	0.0801
Loa Loa (eye worm)	ctsf protein	0.0016	0.0179	0.0179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Onchocerca volvulus	Peroxidasin homolog	0.0312	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0179	0.0179
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0041	0.099	0.109
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0404	0.0479
Onchocerca volvulus		0.0101	0.2986	0.2986
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.3166	0.537
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0047	0.1197	0.2442
Toxoplasma gondii	hypothetical protein	0.0088	0.2565	0.4202
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0018	0.024	0.0107
Onchocerca volvulus		0.0041	0.099	0.099
Echinococcus granulosus	BC026374 protein S09 family	0.0024	0.044	0.044
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0018	0.0243	0.0243
Echinococcus multilocularis	fibropellin Ia	0.0101	0.2986	0.2953
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0179	0.0179
Echinococcus multilocularis	aldo keto reductase	0.0041	0.099	0.0948
Leishmania major	prostaglandin f synthase, putative	0.0041	0.099	0.1624
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0018	0.024	0.0264
Toxoplasma gondii	hypothetical protein	0.0047	0.1197	0.1794
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0024	0.044	0.0484
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0018	0.0243	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0143	0.4386	0.4386
Entamoeba histolytica	aldose reductase, putative	0.0041	0.099	0.109
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.9085	1
Schistosoma mansoni	single-minded	0.0047	0.121	0.121
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Brugia malayi	PAS domain containing protein	0.0047	0.121	0.121
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Loa Loa (eye worm)	oxidoreductase	0.0041	0.099	0.099
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.021	0.0077
Leishmania major	cathepsin L-like protease	0.0062	0.17	0.2846
Brugia malayi	EGF-like domain containing protein	0.0101	0.2986	0.2986
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0024	0.044	0.0395
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0024	0.044	0.064
Loa Loa (eye worm)	hypothetical protein	0.0024	0.044	0.044
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1799	0.198
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Toxoplasma gondii	exonuclease III APE	0.0018	0.0246	0.0117
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1077	0.2143
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.3166	0.3485
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0179	0.0197
Echinococcus multilocularis	neurogenic locus notch protein	0.0101	0.2986	0.2953
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.3166	0.3485
Schistosoma mansoni	hypothetical protein	0.0101	0.2986	0.2986
Loa Loa (eye worm)	acetylcholinesterase 1	0.0143	0.4386	0.4386
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0179	0.0197
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0018	0.0243	0.0338
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0041	0.099	0.099
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.024	0.0107
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0146	0.4504	0.4504
Trichomonas vaginalis	aldo/keto reductase, putative	0.0041	0.099	0.109
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1077	0.1185

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.62 nM	Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay	ChEMBL.	18951784
IC50 (binding)	= 1539 nM	Inhibition of canine retina PDE6 by scintillation proximity assay	ChEMBL.	18951784

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL444157

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 949888