TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 601.734 | Formula: C38H39N3O4
H donors: 0 H acceptors: 4 LogP: 6.28 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: CCCC(=O)N(c1ccc2c(c1)C(=O)C(C1(O2)CCN(CC1)C(=O)c1cc(nc(c1)c1ccccc1)c1ccccc1)(C)C)C
InChi: 1S/C38H39N3O4/c1-5-12-34(42)40(4)29-17-18-33-30(25-29)35(43)37(2,3)38(45-33)19-21-41(22-20-38)36(44)28-23-31(26-13-8-6-9-14-26)39-32(24-28)27-15-10-7-11-16-27/h6-11,13-18,23-25H,5,12,19-22H2,1-4H3
InChiKey: PWQLCFCAHKTMLW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0032	0.0201	0.0383
Schistosoma mansoni	ankyrin 23/unc44	0.0032	0.0201	0.0383
Echinococcus multilocularis	netrin receptor unc 5	0.0032	0.0201	0.0201
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0399	0.4817
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0399	0.5288
Onchocerca volvulus		0.0048	0.0399	0.1954
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2048	0.6672
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.305	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0399	0.6218
Echinococcus granulosus	pyruvate kinase	0.0034	0.0233	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0001	0.0002
Brugia malayi	jmjC domain containing protein	0.0059	0.0542	0.1037
Entamoeba histolytica	hypothetical protein	0.0036	0.0255	0.2156
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0966	0.0966
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0233	0.0233
Brugia malayi	Carboxylesterase family protein	0.0073	0.072	0.1376
Schistosoma mansoni	hypothetical protein	0.017	0.1934	0.3698
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.031	0.3692	0.3692
Leishmania major	hypothetical protein, conserved	0.0025	0.012	0.1866
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0025	0.012	0.0229
Onchocerca volvulus		0.0073	0.072	0.3635
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0786	0.1504
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0786	0.0786
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0447	0.0447
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0039	0.0075
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0224	0.2715
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0334	0.0639
Echinococcus multilocularis	acetylcholinesterase	0.0433	0.5229	0.5229
Brugia malayi	STAT protein, DNA binding domain containing protein	0.029	0.3441	0.6582
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0388	0.0742
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0447	0.5999
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Echinococcus granulosus	acetylcholinesterase	0.0433	0.5229	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0248	0.2799
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0001	0.0001
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0786	0.1504
Echinococcus multilocularis	Ankyrin	0.0032	0.0202	0.0202
Brugia malayi	jmjC domain containing protein	0.0059	0.0542	0.1037
Schistosoma mansoni	pyruvate kinase	0.0067	0.0642	0.1227
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0231	0.0442
Echinococcus granulosus	pyruvate kinase	0.0067	0.0642	0.1227
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0542	0.1037
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0409	0.0783
Loa Loa (eye worm)	pyruvate kinase	0.0067	0.0642	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0231	0.0442
Mycobacterium ulcerans	pyruvate kinase	0.0067	0.0642	0.8066
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Brugia malayi	CHE-14 protein	0.0042	0.0334	0.0639
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0001	0.0001
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Schistosoma mansoni	ap endonuclease	0.0019	0.0039	0.0075
Brugia malayi	Carboxylesterase family protein	0.0073	0.072	0.1376
Echinococcus granulosus	pyruvate kinase	0.0034	0.0233	0.0446
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0001	0.0002
Onchocerca volvulus	Pyruvate kinase homolog	0.0067	0.0642	0.3226
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.106	0.2027
Entamoeba histolytica	hypothetical protein	0.0036	0.0255	0.2156
Echinococcus granulosus	pyruvate kinase	0.0067	0.0642	0.1227
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0001	0.0002
Trichomonas vaginalis	pyruvate kinase, putative	0.0067	0.0642	0.2001
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0475
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0447	0.5999
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0399	0.4817
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0255	0.0488
Schistosoma mansoni	hypothetical protein	0.0032	0.0201	0.0383
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0399	0.3592
Echinococcus multilocularis	protein patched	0.0042	0.0334	0.0334
Plasmodium vivax	pyruvate kinase, putative	0.0067	0.0642	0.8163
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1572	0.1572
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.031	0.3692	0.7061
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0233	0.0233
Echinococcus granulosus	BC026374 protein S09 family	0.0073	0.072	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Echinococcus granulosus	carboxylesterase 5A	0.0433	0.5229	1
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0248	0.3158
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0786	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0334	0.0334
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.072	0.1376
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0073	0.072	0.072
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.305	1
Plasmodium falciparum	pyruvate kinase	0.0067	0.0642	0.8163
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0039	0.05
Loa Loa (eye worm)	pyruvate kinase-PB	0.0047	0.0388	0.0742
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0433	0.5229	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0067	0.0642	0.1227
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0002
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0001	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.305	1
Plasmodium falciparum	pyruvate kinase 2	0.0034	0.0233	0.2969
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0032	0.0201	0.0201
Echinococcus multilocularis	pyruvate kinase	0.0053	0.0465	0.0465
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0142	0.1801
Entamoeba histolytica	hypothetical protein	0.0036	0.0255	0.2156
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0014
Schistosoma mansoni	hypothetical protein	0.0041	0.0315	0.0602
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0454	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0433	0.5229	1
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0334	0.0639
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0039	0.0612
Echinococcus granulosus	GPCR family 2	0.0016	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0399	0.0763
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0542	0.1037
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.012	0.1523
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0399	0.0763
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Loa Loa (eye worm)	carboxylesterase	0.0073	0.072	0.1376
Entamoeba histolytica	hypothetical protein	0.0036	0.0255	0.2156
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0224	0.2715
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.012	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0201	0.0383
Echinococcus multilocularis	acetylcholinesterase	0.0433	0.5229	0.5229
Onchocerca volvulus	Glucosylceramidase homolog	0.017	0.1934	1
Brugia malayi	hypothetical protein	0.0073	0.072	0.1376
Toxoplasma gondii	exonuclease III APE	0.0019	0.0039	0.05
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0642	0.1227
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0409	0.0783
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.1041	0.1991
Schistosoma mansoni	hypothetical protein	0.0041	0.0315	0.0602
Onchocerca volvulus		0.0073	0.072	0.3635
Onchocerca volvulus	Pyruvate kinase homolog	0.0067	0.0642	0.3226
Brugia malayi	hypothetical protein	0.0036	0.0255	0.0488
Echinococcus multilocularis	para nitrobenzyl esterase	0.0073	0.072	0.072
Chlamydia trachomatis	pyruvate kinase	0.0067	0.0642	0.7315
Echinococcus granulosus	netrin receptor unc 5	0.0032	0.0201	0.0383
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0067	0.0642	0.7759
Echinococcus granulosus	neuroligin	0.0073	0.072	0.1376
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.012	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Brugia malayi	Carboxylesterase family protein	0.0073	0.072	0.1376
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0073	0.072	0.072
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0039	0.0612
Onchocerca volvulus		0.005	0.0425	0.2088
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0542	0.0542
Schistosoma mansoni	netrin receptor unc5	0.0032	0.0201	0.0383
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0259	0.305	0.5834
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0475
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0447	0.4744
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2776	0.2776
Brugia malayi	Carboxylesterase family protein	0.0433	0.5229	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0425	0.0812
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0399	0.3592
Onchocerca volvulus		0.0073	0.072	0.3635
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0399	0.6218
Echinococcus multilocularis	tumor protein p63	0.0339	0.4052	0.4052
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.1041	0.1041
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0334	0.0639
Onchocerca volvulus		0.0073	0.072	0.3635
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0475
Echinococcus granulosus	acetylcholinesterase	0.0433	0.5229	1
Trypanosoma brucei	pyruvate kinase 1	0.0067	0.0642	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0409	0.0783
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0399	0.6218
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0399	0.4817
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0399	0.3994
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0425	0.0812
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0039	0.0075
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.072	0.1376
Loa Loa (eye worm)	pyruvate kinase	0.0067	0.0642	0.1227
Brugia malayi	Carboxylesterase family protein	0.0433	0.5229	1
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0399	0.4817
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0399	0.3994
Brugia malayi	Probable ClpP-like protease	0.0078	0.0786	0.1504
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0399	0.0763
Mycobacterium ulcerans	carboxylesterase, LipT	0.0073	0.072	0.9109
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0255	0.0255
Schistosoma mansoni	hypothetical protein	0.0034	0.0231	0.0442
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Loa Loa (eye worm)	pyruvate kinase	0.0067	0.0642	0.1227
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.2048	0.6672
Brugia malayi	hypothetical protein	0.0025	0.012	0.0229
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.072	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0786	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0142	0.1801
Loa Loa (eye worm)	hypothetical protein	0.0073	0.072	0.1376
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.012	0.1866
Echinococcus multilocularis	pyruvate kinase	0.0067	0.0642	0.0642
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0067	0.0642	0.8856
Onchocerca volvulus	Pyruvate kinase homolog	0.0067	0.0642	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2776	0.531
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0002
Brugia malayi	Uncoordinated protein 44	0.0032	0.0201	0.0383
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0073	0.072	0.1376
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0399	0.3592
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0001	0.0002
Schistosoma mansoni	pyruvate kinase	0.0067	0.0642	0.1227
Schistosoma mansoni	BC026374 protein (S09 family)	0.0073	0.072	0.1376
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0039	0.0612
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0786	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0255	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0202	0.0386
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0002
Echinococcus granulosus	Ankyrin	0.0032	0.0202	0.0386
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0399	0.4817
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.305	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0399	0.4817
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0067	0.0642	1
Schistosoma mansoni	hypothetical protein	0.017	0.1934	0.3698
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0399	0.4817
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0067	0.0642	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0039	0.0075
Schistosoma mansoni	gliotactin	0.0073	0.072	0.1376
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0001	0.0002
Onchocerca volvulus		0.0048	0.0409	0.2008
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0039	0.05
Plasmodium vivax	pyruvate kinase 2, putative	0.0034	0.0233	0.2969
Toxoplasma gondii	pyruvate kinase PyK1	0.0067	0.0642	0.8163
Toxoplasma gondii	pyruvate kinase PyKII	0.0034	0.0233	0.2969
Giardia lamblia	Pyruvate kinase	0.0067	0.0642	1
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0201	0.0383
Echinococcus multilocularis	carboxylesterase 5A	0.0433	0.5229	0.5229
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0334	0.0979
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0224	0.2715
Loa Loa (eye worm)	STAT protein	0.029	0.3441	0.6582
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0067	0.0642	0.1227
Brugia malayi	hypothetical protein	0.0237	0.2776	0.531
Trichomonas vaginalis	pyruvate kinase, putative	0.0067	0.0642	0.2001
Loa Loa (eye worm)	carboxylesterase	0.0073	0.072	0.1376
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0259	0.305	0.5834
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0399	0.5288
Schistosoma mansoni	ap endonuclease	0.0019	0.0039	0.0075
Giardia lamblia	Pyruvate kinase	0.0034	0.0233	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0248	0.0475
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.012	0.1523
Schistosoma mansoni	pyruvate kinase	0.0034	0.0233	0.0446
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0542	0.1037
Trypanosoma brucei	pyruvate kinase 1, putative	0.0067	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0399	0.0763
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0073	0.072	0.2259
Echinococcus granulosus	tumor protein p63	0.0339	0.4052	0.7749
Schistosoma mansoni	hypothetical protein	0.0041	0.0315	0.0602
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.043	0.0822
Echinococcus multilocularis	neuroligin	0.0073	0.072	0.072
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.012	0.1866
Echinococcus granulosus	expressed conserved protein	0.0093	0.0966	0.1847
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0142	0.137
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.305	1
Loa Loa (eye worm)	hypothetical protein	0.0433	0.5229	1
Schistosoma mansoni	patched 1	0.0042	0.0334	0.0639
Loa Loa (eye worm)	hypothetical protein	0.005	0.043	0.0822
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0039	0.0612
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.1041	0.1991
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0542	0.1037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0224	0.2715
Brugia malayi	Carboxylesterase family protein	0.0073	0.072	0.1376
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0447	0.0856
Schistosoma mansoni	hypothetical protein	0.0041	0.0315	0.0602
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0786	1
Schistosoma mansoni	acetylcholinesterase	0.0073	0.072	0.1376
Loa Loa (eye worm)	acetylcholinesterase 1	0.0433	0.5229	1
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0399	0.0763
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.043	0.0822
Trichomonas vaginalis	glucosylceramidase, putative	0.0259	0.305	1
Toxoplasma gondii	hypothetical protein	0.0027	0.0142	0.1801
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0248	0.3158
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.1041	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0334	0.0639
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0032	0.0202	0.0386
Leishmania major	pyruvate kinase	0.0067	0.0642	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1572	0.3007
Leishmania major	pyruvate kinase	0.0067	0.0642	1
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2776	0.531
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1041	0.1991
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.002	0.0057	0.0108
Onchocerca volvulus	Netrin receptor homolog	0.0032	0.0201	0.0913
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0201	0.0383
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0073	0.072	0.1376
Echinococcus granulosus	geminin	0.017	0.1934	0.3698
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0786	1
Onchocerca volvulus		0.0073	0.072	0.3635
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0032	0.0201	0.0383
Echinococcus granulosus	pyruvate kinase	0.0034	0.0233	0.0446
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.072	0.1376
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0002
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0248	0.3073
Loa Loa (eye worm)	carboxylesterase	0.0433	0.5229	1
Echinococcus multilocularis	pyruvate kinase	0.0067	0.0642	0.0642
Echinococcus multilocularis	geminin	0.017	0.1934	0.1934
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0233	0.0233
Trichomonas vaginalis	glucosylceramidase, putative	0.017	0.1934	0.6291
Schistosoma mansoni	hypothetical protein	0.0036	0.0255	0.0488
Trichomonas vaginalis	spcc417.12 protein, putative	0.0073	0.072	0.2259
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0039	0.0039
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0073	0.072	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0073	0.072	0.1376
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0542	0.1037
Entamoeba histolytica	pyruvate kinase, putative	0.0047	0.0388	0.3481
Brugia malayi	Death domain containing protein	0.0032	0.0201	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0399	0.0763
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.072	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0542	0.1037
Echinococcus granulosus	death domain containing protein	0.0032	0.0201	0.0383
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.012	0.1866
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.043	0.0822
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0399	0.4817
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0786	0.1504

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL443919

Bibliographic References

No literature references available for this target.

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Detailed information for compound 950322